Báo cáo y học: "GPG-NH2 acts via the metabolite aHGA to target HIV-1 Env to the ER-associated protein degradation pathway" pptx
Báo cáo y học: " Derivation and preliminary validation of an administrative claims-based algorithm for the effectiveness of medications for rheumatoid arthritis"
... adherence to the RA therapy is consistent with clinical trials methodology where patients who do not adhere to the study protocol, including continuing to take the medication, are generally excluded ... underlying RA disease activity for some patients (e.g. those with concomitant fibromyalgia). Moreover, patients may fear that they will worsen after switching to a new therap...
Ngày tải lên: 25/10/2012, 10:45
Báo cáo y học: " Laugh Yourself into a Healthier Person: A Cross Cultural Analysis of the Effects of Varying Levels of Laughter on Health"
... hepatobiliary system, genitourinary system, reproductive system, CNS and psychiatric conditions, and then to specify the name of that con- dition. If the participant failed to indicate the ... pathways, the “voluntary path” and the “involuntary path” otherwise known as the “emotionally-driven path”. (5) The voluntary path- way begins from the premotor opercular areas a...
Ngày tải lên: 26/10/2012, 09:57
Báo cáo y học: "Thioglycosides as inhibitors of hSGLT1 and hSGLT2: Potential therapeutic agents for the control of hyperglycemia in diabetes"
... study was to evaluate the inhibitory effect of some thioglycosides synthesized in our laboratory on human hSGLT1 and hSGLT2 –as a potential therapeutic alternative for the control of hyperglycemia, ... Among these, thioglycosides are im- portant to consider because they are not hydrolysed by β-glucosidases in the intestine and can be adminis- tered orally [27]. Therefore, the...
Ngày tải lên: 26/10/2012, 10:04
Báo cáo y học: "Comparison of a Two-Lead, Computerized, Resting ECG Signal Analysis Device, the MultiFunction-CardioGramsm or MCG (a.k.a. 3DMP), to Quantitative Coronary Angiography for the Detection of Relevant Coronary Artery Stenosis (70%)
... locally recorded, but remotely analyzed at a central US data facility, due to the size and complexity of the digital signal process- ing, the analysis by multiple mathematic functions, and the ... according to whether the patients had prior revascularization. The boundaries of the box are Tukey’s hinges. The median is identified by the line inside the box. The len...
Ngày tải lên: 03/11/2012, 10:58
Báo cáo Y học: Baboon cytochrome P450 17a-hydroxylase/17,20-lyase (CYP17) Characterization of the adrenal microsomal and cloned enzymes docx
... subsequent hydroxylation by cytochrome P450 21-hydroxylase (CYP21). It is, however, possible for the 17a-hydroxylated intermediate to remain bound to the enzyme or for the released product to rebind ... F and G and the F-G loop. Keywords: CYP17; baboon; cytochrome P450; 17a- hydroxylase; 17, 20-lyase. The steroidogenic cytochromes P450 are a unique group of enzymes responsible...
Ngày tải lên: 08/03/2014, 09:20
Báo cáo Y học: Trehalose-phosphate synthase of Mycobacterium tuberculosis Cloning, expression and properties of the recombinant enzyme pdf
... trehalose appear to have an important and probably essential function in the physiology of many organisms. The most widely demonstrated pathway for the synthesis of trehalose involves two enzymes that catalyze ... and then cells were harvested and disrupted by sonication. The cytosolic fraction was then assayed for TPS enzymatic activity, using either GDP–glucose or UDP–glucose as...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: Identification of mammalian-type transglutaminase in Physarum polycephalum Evidence from the cDNA sequence and involvement of GTP in the regulation of transamidating activity potx
... inhibit the enzymatic activity of PpTGase might be similar to that by which they inhibit the enzymatic activity of TGase 4. Hydrolysing activity of GTP was also found in the purified PpTGase protein ... inhibition by GTP was not observed. These results suggest that the TGase activity is regulated by the presence of GTP and Ca 2+ . Additionally, in order to confirm the specifici...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: Heterologous expression and folding analysis of a b-tubulin isotype from the Antarctic ciliate Euplotes focardii ppt
... Due to the deviation of ciliates from the universal genetic code [27] there is still uncertainty about the amino acid at position 21 encoded by a TAG codon, that may specify glutamine or tryptophan. ... Therefore, in order to subclone into the expression vector pET11a (NdeI/BamHI cut), the pUC18 vector containing the b-T1 coding region was amplified by inverted PCR with primers...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1 potx
... raises the question as to whether the inhibitory effect of hspry4 on ras activation is (solely) due to an activity of hspry4 at the inner plasma membrane. spry1 and spry2 were recently shown to associate ... and/or target TESK1 or other proteins for degradation by the proteasome. Other questions needing to be addressed include whether hspry4 can be phosphorylated and palmi...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo Y học: Function and cellular localization of farnesoic acid O -methyltransferase (FAMeT) in the shrimp, Metapenaeus ensis ppt
... FAMeT may interact with the eyestalk neuropeptides and thereby regulate the synthesis and role of MF. All this suggests that FAMeT is a key regulatory enzyme in the MF biosynthetic pathway of the ... larger protein in the eyestalk may be attributable to binding of FAMeT with the eyestalk factors related to MF biosynthesis in the shrimp. Another alterna- tive is that the...
Ngày tải lên: 31/03/2014, 21:21