Báo cáo y học: " The mutation T477A in HIV-1 reverse transcr

Báo cáo y học: " The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the p51-RNH cleavage site" ppt

... 7:6 http://www.retrovirology.com/content/7/1/6 Page 2 of 9 RESEARC H Open Access The mutation T477A in HIV-1 reverse transcriptase (RT) restores normal proteolytic processing of RT in virus with Gag-Pol mutated in the ... shown). Effect of the RT T477A substitution on intravirion processing of the Pr160 Gag-Pol polyprotein To better...

Ngày tải lên : 12/08/2014, 23:22

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Báo cáo y học: "The S100A8/A9 heterodimer amplifies proinflammatory cytokine production by macrophages via activation of nuclear factor kappa B and p38 mitogen-activated protein kinase in rheumatoid arthritis" potx

... highly expressed by CD68 + macrophages, in particular the cells localized to the lining layer. However, S100A8/A9 staining was negligible in CD68-negative cells in the sublining layer, including lymphocytes ... by synovial lining macrophage, may play a role in amplifying proinflammatory cytokine responses via activation of NF-κB and p38 MAPK in RA. Competing interests Th...

Ngày tải lên : 09/08/2014, 07:20

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Báo cáo y học: "The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study" pptx

... were obtained when the subject with a cyst but no BML was excluded. We extended our observation by examining the effect of increasing grade of severity of subchondral bone abnormality (grade 1, normal; ... study of 32 patients with knee OA found that 11 (92%) of 12 of cysts developed within BMLs over ~18 months [13]. This is consistent with the findings of a more re...

Ngày tải lên : 12/08/2014, 12:20

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Báo cáo y học: "The association between patellar alignment on magnetic resonance imaging and radiographic manifestations of knee osteoarthritis" ppsx

... by an Arthritis Foundation Clinical Sciences Grant. The study sponsor was not involved in study design, in the collection, analysis, and interpretation of data, in the writing of the report, ... and coordination of the study, read the MRIs, and prepared the manuscript. YZ participated in the design of the study. JN performed the statistical analy- ses. JG...

Ngày tải lên : 09/08/2014, 10:20

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Báo cáo y học: " A novel duplex real-time reverse transcriptase-polymerase chain reaction assay for the detection of hepatitis C viral RNA with armored RNA as internal control" docx

... real- time RT- PCR assay. Intrinsic performance of the duplex real-time RT- PCR assay Linearity Linearity of the duplex real-time RT- PCR assay was determined using serial 10-fold dilutions of a clinical sample ... sample with of low load of HCV. Assay of 109 serum samples by using commercial kits The results obtained by the duplex real-time RT- PCR assay were identi...

Ngày tải lên : 12/08/2014, 04:20

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Báo cáo y học: "The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells" ppsx

... clinical arthritis in CAIA models. In both models, infiltration of monocytes and macrophages into the synovium was completely inhi bited and importantly, the bone and cartilage integrity of the ... cartilage destruction. To determine the inflammatory cell types affected in the joint, we examined the cellularity of the synovial fluid by scoring for the number s of...

Ngày tải lên : 12/08/2014, 17:22

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Báo cáo y học: " A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus" docx

... that the difference in the binding site between the fMLF peptide and HIV-1 is one of the reasons why the fMLF peptide could not efficiently interfere with the inter- action of FPRL1 with HIV-1. The ... a determinant of the FPRL1 use of HIV-1 as a coreceptor lies in the V3 region. Therefore, we determined the amino acid sequences of the V3 regions...

Ngày tải lên : 13/08/2014, 05:21

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Báo cáo y học: " The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage" potx

... determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T21 5Y on removal of thymidine ... [15]. Conclusion The strategy of combining mutation- selecting drugs with “resensitized” drugs has already been discussed for the reverse transcriptase muta...

Ngày tải lên : 10/08/2014, 05:22

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Báo cáo y học: "The Systemic Inflammatory Response Syndrome (SIRS) in acutely hospitalised medical patients: a cohort study"

... identified by two or more symptoms including fever or hypothermia, tachycardia, tachypnoea and change in blood leucocyte count. The relationship between SIRS symptoms and morbidity and mortality in medical ... 28-day mortality. Background Sepsis is a systemic inflammatory response to a confirmed or suspected infection. Clinically, the Systemic Inflamma- tory Response Syndrome (SIRS) i...

Ngày tải lên : 25/10/2012, 09:56

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Báo cáo y học: "The epidemiology of medical emergency contacts outside hospitals in Norway - a prospective population based study"

... showed the highest inci- dence during daytime with a proportion of 45% (table 4). A29 “Breathing difficulties” was the most used Index- category in the “all other” group with nearly 5% of the total. ... for 11% of the patients. The table also shows that in 26% of the situations, the casualty clinics were directly involved in patient care, either as final plac...

Ngày tải lên : 25/10/2012, 09:56

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