Báo cáo y học: " T-cell activation promotes tumorigenesis in inflammation-associated cancer" potx

... USA). Receptor tyrosine kinases (RTK) activation profiling using antibody arrays The activation of RTK and their downstream signaling pathways were analyzed using the Proteome Profiler™ Array kits (ARY001 ... routine hematoxylin and eosin (H&E) staining, and immunohistochemical staining was performed by the avidin-biotin-peroxidase complex method, using the fol- lowing monoclonal (mc)...

Ngày tải lên: 13/08/2014, 15:21

... 20 35 14 No Yes Yes BT-474 RAB22A 20 MYO9B 19 9 12 No Yes Yes BT-474 SKA2 17 MYO19 17 8 7 Yes Yes Yes BT-474 DIDO1 20 KIAA0406 20 8 1 Yes No BT-474 STARD3 17 DOK5 20 4 6 Yes Yes Yes BT-474 LAMP1 ... 10 Yes Yes Yes SK-BR-3 ANKHD1 5 PCDH1 5 12 6 Yes No Yes SK-BR-3 CCDC85C 14 SETD3 14 6 6 Yes No Yes SK-BR-3 SUMF1 3 LRRFIP2 3 14 5 Yes No SK-BR-3 WDR67 8 ZNF704 8 3 3 Yes Yes Yes SK-BR-3 CYTH1 ......

Ngày tải lên: 09/08/2014, 22:23

... repre- sent increasingly large numbers of genes, and the effi- ciency and relatively low cost of arrays, particularly cDNA arrays [7], will probably lead to the increasing use of this technology for ... subclassifying hematopoietic neoplasms, because leukemia and lymphoma already have strong pre-existing classification frameworks, permitting the study of focused problems in taxonomy. In a...

Ngày tải lên: 12/08/2014, 18:20

... lung injury by inducing expression of cytokines including tumor necrosis factor and IL-6 and IL-8 [149]. These cytokines may in turn stimulate the production of many inflammatory mediators, leading ... in the initial events in lung injury by activating neutrophils to aggregate and release elastase and oxygen radicals, increasing neu- trophil adherence, activating mast cells, and inducin...

Ngày tải lên: 12/08/2014, 18:20

... while maintaining infection control measures), and serve as a way to train treatment teams at different hospital sites. Indeed, internet-based technology proved invaluable during the SARS outbreak in ... placed in quarantine after exposure, some of them falling ill, becoming critically ill and even succumbing to SARS. Staff morale was addressed in some institutions by encouraging and co...

Ngày tải lên: 12/08/2014, 20:21

... with a recently devel - oped XMRV neutralizing assay which measures vi ral neutralizing activity using a GFP-encoding XMRV and flow cytometry [14]. Positive seroreactivity was defined as 100% ... 4D) sera marginally reduced the XMRV infectivity (over 80% block of XMRV infectivity at a 10-fold dilution). However, by Western blot probing cell lysates from XMRV-infected and uninfected cells, ......

Ngày tải lên: 13/08/2014, 01:20

... human and mouse PXR ligand binding domains. By modeling the human PXR ligand binding domain we have identified and mutated two polar residues in the puta- tive ligand binding pocket which differ between ... determinant for the transcrip- tional regulation of the drug metabolizing enzyme family of heme-containing monooxygenases P450 CYP3A [1–4]. Consequently this nuclear receptor is likely to...

Ngày tải lên: 08/03/2014, 16:20

... with CD2 augments T CR-CD3-mediated activation of protein tyrosine kinase p72syk, resulting in incresed tyrosine phosphorylation of adapter proteins, Shc and Cbl. Int. Immunol. 10, 833–845. 57. Aguirre ... containing th e GAL4 DNA- binding domain and the c-Ju n activation domain (residues 1–223) in wild-type and mutant forms ( not phosphorylat- able by mutation of both serines 63 and...

Ngày tải lên: 08/03/2014, 22:20

... YSYTATYHIYDLTNGEFIR 1098.96 (2+) 403–421 VTQDSLFYSSNEFEGYPGR The 97 kDa band obtained following biotinylated fluorophosphonate labelling of bovine chondrocytes was trypsin digested and analysed ... terminus, a region with several potential N-glycosylation sites, a cysteine rich substrate-binding domain and a stretch of 200 amino acids at the carboxyl terminus containing the catalytic serine,...

Ngày tải lên: 09/08/2014, 07:20

... clearly in keeping with the growing body of evi- dence demonstrating that nonimmune mechanisms are involved in weakness induction in myositis [15] and that these mechanisms likely cause weakness by ... concepts in the Idiopathic Inflammatory Myopathies: Polymyositis, Dermatomyositis, and related disorders. Ann Intern Med 1989, 111:143-157. 7. Olsen N, Park J: Inflammatory myopathies:...

Ngày tải lên: 09/08/2014, 07:20