Báo cáo y học: "Expression Section in the HIV Drug Resistance Program at the National Cancer Institute-Frederick" pdf

... Center at New Orleans and later at the National Cancer Institute in Frederick, Maryland. While in the Casey laboratory, Dave identified the enhancer elements in the long terminal repeat that regulate ... Pharmacology in 1982 from the State University of New York (SUNY) at Buffalo. His graduate adviser at SUNY Buffalo was Dr. Yung-Chi "Tommy" Cheng who m...

Ngày tải lên: 12/08/2014, 23:22

... qualitative VL testing and subtype-independent confirmatory HIVDR genotyping with automated base-calling software to reduce operator errors in identifying pure mutations and mixture mutations. ... the patients on treatment in RLS receive a first- line drug regimen based on RT-inhibitors only [6]. Moreover, the mutat ions, commonly present in patients failing a first-line drug re...

Ngày tải lên: 10/08/2014, 05:21

... min at 72 °C, then 25 cycles of 30 s at 94 °C, 30 s at 68 °C and 3 min at 72 °C, then 5 min at 72 °C. Cloning and sequencing The amplified cDNAs were ligated into the plasmid pCR TM -II using the ... secondary pathways can occur: adenylate cyclase catalyses the formation of cAMP, whereas phospholipase C hydrolyses membrane phospha- tidylinositol, liberating inositol 1,4,5-tri...

Ngày tải lên: 17/03/2014, 23:20

... & Therapy October 2005 Vol 7 No 5 Meyer and Pap at the same time they strengthen the concept of p38 and ERK as important MAPKs in the inflamed synovium. In line with previous data, the results ... MAPK kinases (MKKs), which largely determine the balance of MAPK activation in response to inflammatory stimuli [8,9]. The second interesting observation by Goertz and collea...

Ngày tải lên: 09/08/2014, 07:20

... erosions (representing cumulative disease activity) was not analyzed in the present study. Despite limitations, QUEST-RA is a unique program that has succeeded to date in collecting data on clinical RA patients ... comorbidities, including CV events, was established by a record review, a detailed clinical examination, and asking the patient at the time of the visit. The use...

Ngày tải lên: 09/08/2014, 10:23

... 0.27%). Together, these findings indi- cate that there is constancy in the epidemiologic charac- teristics of ankylosing spondylitis. The incidence and prevalence of ankylosing spondylitis has also ... epidemiology of systemic lupus erythematosus A population-based study examined the incidence and mortality of systemic lupus erythematosus (SLE) in a geographically defined population...

Ngày tải lên: 09/08/2014, 14:20

... currently available different models of latency in primary T- cells. Others have demonstrated the synergism obtained by treatment with a combination of prostratin and the HDACi vorinostat in both ... cell line and primary cell model of latent HIV infection [46]. Herein we also demonstrated the additive effects in activation of HIV replication by combining the PKC activ...

Ngày tải lên: 13/08/2014, 01:21

... from the formamide-type intermediate analog. The data suggest that the enzyme catalyzes an ordered reaction in which the hydrolytic release of pyrophosphate precedes the hydrolytic attack of the imidazole ... bonds. Keywords: formate; GTP cyclohydrolase; imidazole ring; pyrophosphate; zinc ion. GTP cyclohydrolases catalyze the first steps in the biosyn- thetic pathways of r...

Ngày tải lên: 23/03/2014, 21:20

... desensitized in asthma, in part owing to the inflammatory effect of cysteinyl leukotrienes. 21 In addition, there are over 100 different inflammatory mediators that modulate airway smooth muscle tone in humans. ... study has failed given the complexity of chronic airway inflammation and remodelling in asthma, even if the activity of allergy-related airway inflammation is known...

Ngày tải lên: 08/08/2014, 21:20

... concentrations, the anti- inflammatory effect may predominate, and patch test results may be negative. On the other hand, if the concentration used for patch testing on intact skin is too low, a negative ... measuring the diameter of the reaction and performing a morphologic description of the erythematous swelling, erythematous infiltrate, erythema only, and eczema with papulatio...

Ngày tải lên: 08/08/2014, 21:20