Báo cáo y học: " Biochemical and virological analysis of the 18-residue C-terminal tail of HIV-1 integrase" pot

... comprises the heart of the C-terminal domain is the only part of HIV-1 integrase yet to be visualized by structural biology. To ascertain the role of the tail region in integrase function and HIV-1 ... as the tail, were present in the two-domain HIV-1 construct, they were disordered and therefore unseen in the resulting crystal structure [32]. The roles...

Ngày tải lên: 12/08/2014, 23:22

... in identifying DC subsets have improved the resolution of subset heterogeneity. We therefore utilised robust assays to quantify and characterise the distribution and phenotype of mDCs and pDCs ... conceived the study design. SLJ car- ried out the DC enumeration, purification, cell culture, flow cytometry, ELISA and statistical analysis. ARF participated in the flow cyto...

Ngày tải lên: 09/08/2014, 07:20

... 94%. Thus RRE region is one of the most conserved reg ions in the genomic RNA between HIV-1 subtypes B and C and with probably other subtypes as well. The analysis ofintra-subtypedivergence(geneticdistancefrom Indian ... p C and D as in the case of S1 and VT1. Remarkably, gross changes (particularly D and Sharma et al. AIDS Research and Therapy 2010, 7:28 http://ww...

Ngày tải lên: 10/08/2014, 05:21

... State Key Laboratory of Veterinary Etiological Biology, National Foot- and- Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Xujiaping No.1, Yanchangpu, ... this outbreak of orf was carried out, and the phylogenetic relationship of the virus with other ORFV sequences available in GenBank was determined. This is the first r...

Ngày tải lên: 12/08/2014, 04:20

... Karachi, in the Southern region of Pakistan, then spread in poultry throughout the country and was Figure 2 Phylogenetic tree of the Pakistani AIV N3 NA genes and other selected AIV isolates. The tree ... had nt identity of around of 92.7% to the other H7 isolates. Phylogenetic analysis showed that the PB1 of all the Pakistani H7N3 viruses grouped together as a d...

Ngày tải lên: 12/08/2014, 04:20

... barrier. Histo- grams of frequency distribution of cytoplasm volume density in endothelial (A) and epithelial (C) compartments and of total surface of the endothelial (B) and epithelial (D) compartments ... frequency histograms of volume and surface distribution of epithelial compartment of the thin portion of the air- blood barrier. F and P indicate either fa...

Ngày tải lên: 12/08/2014, 16:20

... Microscopy & Microanalysis, The University of Sydney. Author details 1 Faculty of Pharmacy, University of Sydney, NSW 2006, Australia. 2 Australian Centre for Microscopy & Microanalysis, ... camera. Acknowledgements The authors are grateful to Dr Scott Lindsay from Veterinary Pathology Diagnostic Services, Faculty of Veterinary Science, University of Sydney, for assistan...

Ngày tải lên: 13/08/2014, 13:20

... nervous system (CNS) as well as the physiology and pathology of the brain. The functions of the CNS are mainly excitation and conduction as reflected in the continuous electrical activity of the brain. ... individuals, thereby aiming at the overall picture in the brain. A hypothesis called ANLSH (astrocyte-neuron lactate shuttle hypothesis) proposes the use of as...

Ngày tải lên: 13/08/2014, 16:21

... reds of increasing intensity, and downregulation with greens of increasing intensity. The dendrogram on the top of the figure represents the similarity matrix of probe sets, the dendrogram to the ... vertebrate development and plays a crucial role in early embryonic development. The nature of the BMP2-expressing cells during the early stages of embryonic deve...

Ngày tải lên: 14/08/2014, 08:20

... DPEVFRCVLNFYRTGKLHYP YEC SAYDDELAFYGI LPEI I G CCYE EYFFDR NRPSFDAILYFYQSGGRLRR PVNVPLDVFSEEI KFYELG GRI ELK. QFDSHI LEKAVEYLNYNLKYSGVSEDDDEI P EFEIP.TEMSLELLLAADYLSI NEVNFRE. I PSHVLSKVCMYFTYKVRYTN. . ... one monomer and β5 of the other monomer; and the packing of α1 from one monomer against α1 and the A1/A2 helical hairpin from the other monomer. The strand-exchanged ami...

Ngày tải lên: 14/08/2014, 14:22