Báo cáo khoa học: "Activated protein C increases sensitivity to vasoconstriction in rabbit Escherichia coli endotoxin-induced shock" potx

... the thoracic aorta during endotoxic shock. Circ Shock 1991, 35:25-30. Key messages • In our model of endotoxinic shock, aPC increases the sensitivity to vasoconstriction. • aPC restores endothelial ... fenofibrate, protects endothelium in rabbit Escherichia coli endotoxin- induced shock. Intensive Care Med 2005, 31:1269-1279. 13. Wiel E, Vallet B, Ten Cate H: The endothelium...

Ngày tải lên: 12/08/2014, 23:22

... original work is properly cited. Abstract Introduction Successful treatment of severe sepsis and septic shock remains a major challenge in critical care medicine. The recently introduced recombinant ... microcirculation, particularly of the intestine, in septic conditions [4,6,8,9]. There is an increasing body of evidence that activated protein C (APC) exerts beneficial effects in t...

Ngày tải lên: 13/08/2014, 03:20

... antigen in both healthy men and indi- viduals with protein C deficiency suggesting that the circu- lating protein C concentration is the limiting factor in the rate of activation of protein C [33]. ... This interaction is a critical step in the host defence against sepsis since inhibition of protein C binding to EPCR (in baboon model) is shown to con- vert the respo...

Ngày tải lên: 10/08/2014, 22:20

Ngày tải lên: 13/08/2014, 01:20

... article is online at http://ccforum.com/content/11/5/164 © 2007 BioMed Central Ltd See related research by Dhainaut et al., http://ccforum.com/content/11/5/R99 APC = activated protein C; ICU = intensive ... clinical evidence. Costs in their study were collected using microcosting methods, which are regarded as the most valid means of measuring health care costs [2]. Not surprisingly, giv...

Ngày tải lên: 13/08/2014, 08:20

... ECM, Brandjes DPM, Büller HR, Levi M: Effects on coagulation and fibrinolysis induced by influenza in mice with a reduced capacity to generate activated protein C and a deficiency in plasminogen ... treated mice and B. recombinant murine activated protein C treated mice (original magnification × 100). C. Total pathology score (described in methods section) 48 and 96 hour...

Ngày tải lên: 13/08/2014, 20:21

... thrombin formation could prevent the activation of throm- bin activatable fi brinolysis inhibitor. Activated throm bin activatable fi brinolysis inhibitor inhibits the chemotactic factors C3 a and C5 a, ... of  brinolysis in addition to systemic in ammation and intense neutrophil in ux into the lung. Activated protein C attenuates coagulation activation and restores  brinoly...

Ngày tải lên: 13/08/2014, 20:22

... In the present issue of Critical Care, Pettila and colleagues report the fi rst single-centred pilot randomized controlled trial of activated protein C (APC) in alcohol- induced acute pancreatitis ... characterizes severe sepsis. Activated protein C (APC) has pleotropic e ects on the immune, coagulation, in ammatory and apoptotic pathways, and has been postulated to bene t...

Ngày tải lên: 13/08/2014, 21:21

... Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases; European Society of Intensive Care Medicine, et ... Versailles. Activated protein C and corticosteroids for human septic shock (APROCCHS). [http://clinicaltrials.gov/ct2/show/ NCT00625209]. 19. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fe...

Ngày tải lên: 14/08/2014, 07:21

... b-arrestin-dependent activation and led to cyclin D1 accumulation, cy- clin D1-cyclin-dependent kinase (CDK) 4 activity and cell cycle progression [46]. The intermediaries between Akt and cyclin D1 accumulation ... lipoxin A 4 receptor; CDK, cyclin-dependent kinase; CREB, cAMP-response element binding; cyt c, cytochrome c; EGFR, epidermal growth factor receptor; ERK, extracellular signal-...

Ngày tải lên: 16/03/2014, 05:20