... provides a clear explanation for the inability of P450scc to cleave the side chain of vitaminD3. Hydroxylation of the side chain of cholesterol at the adjacent carbons C22 and C20, to produce2 0a, 22R-dihydroxycholesterol ... which they arose by the action of P450scc, as well as the products that they gave rise to.This revealed both the major and minor pathways for the metabolism of vitamin D3 by P450scc. Results Metabolism ... School of Biomolecular, Biomedical and Chemical Sciences, The University of Western Australia, Crawley, Australia2 Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee...