Báo cáo y học: " The HBZ gene, a key player in HTLV-1 pathogenesis" doc

... Ohara Y: In vivo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory mark- ers and disease severity in HTLV-1 associated myelopathy/ tropical spastic paraparesis (HAM/TSP). ... anti-apoptotic functions in lymphoma cell lines [38]. Interestingly, HTLV-1 Tax is known to activate both the classical and the alternative NF-κB pathways, and it has b...

Ngày tải lên: 12/08/2014, 23:21

... vitro cross-linking experiments revealed that the G-10L mutant protein is routed to the SecYEG translocon via the SRP pathway, the targeting pathway that is exploited by integral inner-membrane proteins. ... using strain CE1224 as the recipient and strains IQ85 and strain MM152, respectively, as donor strains. To obtain strain CE1513, strain MM88 was used as Fig. 1. Physical charact...

Ngày tải lên: 08/03/2014, 09:20

... regarding the central importance of phagocytosis to human physiology, which culminated in a Noble Prize and laid the groundwork for the field of innate immunity at the opening of the last century ... rheumatoid arthritis patients and these cells display an inflammatory phenotype characterized by increased release of interleukin-1 and tumor necrosis factor following exposure to l...

Ngày tải lên: 09/08/2014, 14:21

... pairs that are physico-chemically more compatible than any other amino acid pairs. These physico-chemi- cally highly compatible amino acid pairs are complemen- tary to each other, by analogy to ... acid); the blue circles indicate amino acids with exceptionally high affinity for the attachment points (e.g., acidic amino acids); these cap- ture the amino acids at the attachment point...

Ngày tải lên: 13/08/2014, 16:21

... grants from the National Institutes of Health (AR 42457, AR 41974 and AI 44142) and by the Mayo Foundation. We thank James W Fulbright for assistance in preparing this manuscript and Linda H Arneson ... inflammatory diseases initiated an era of clinical investigation and estab- lished the foundation of modern clinical immunology. The original descriptions of antinuclear antibodies b...

Ngày tải lên: 09/08/2014, 01:21

... arthritis. Ann Rheum Dis 2008, 67:48-51. 20. Tamai M, Kawakami A, Uetani M, Takao S, Arima K, Iwamoto N, Fujikawa K, Aramaki T, Kawashiri SY, Ichinose K, Kamachi M, Nakamura H, Origuchi T, Ida H, Aoyagi ... physical examination and symptom duration was less than two years. Written informed consent was obtained from all participants. The study was approved by the local Medical Ethical Com...

Ngày tải lên: 09/08/2014, 14:22

... linear, all-inclusive strategy can greatly simplify the situation, as well as maximally leverage the heterogene- ous annotations in the similarity measurement (see Addi- tional data files 11 and ... expectation of the study. The same data analyzed by the Functional Annotation Clustering Tool Due to the redundancy/hierarchy problems in the results obtained from traditional...

Ngày tải lên: 14/08/2014, 08:20

... clinical evaluation within the first two days after arrival, including clinical examinations as well as radiological evaluation, and where infection was sus- pected by the clinical doctor or indicated ... first draft. MS and AL contributed to the design of the study and the interpretation of the data and made a critical revi- sion of the manuscript. All authors have read and a...

Ngày tải lên: 25/10/2012, 09:56

... on the anti- biotic use, financial cost and resistance patterns of leading nosocomial pathogens. Materials and Methods Hospital setting and antibiotic policy: NARP was initiated in Turkey in ... Hospital pharmacy computer data- bases, and 2) International Medication System (IMS). Because Turkey is an inflation country we have esca- lated all antibiotic prices. The cost of antibio...

Ngày tải lên: 25/10/2012, 11:00

... can contain a substantial amount of free a- hydroxyhaem and this can lead to an incorrect interpret- ation of the nature of the enzyme-assisted conversion of a- hydroxyhaem to verdohaem. The reaction ... M .A. & Roy, A. K. (2000) Heme oxygenase-1 in tissue pathology. The Yin and Yang. Am. J. Pathol. 156, 1485–1488. 6. Cary, S.P.L. & Marletta, M .A. (2001) The case of...

Ngày tải lên: 23/03/2014, 21:20