Báo cáo y học: " Enhanced macrophage tropism of HIV in brain and lymphoid tissues is associated with sensitivity to the broadly neutralizing CD4 binding site antibody b12" ppsx

... proximal to the CD4 binding site, increased resistance to b12 neutralization [22]. However, the HIV Enhanced HIV entry into macrophages is associated with sensitivity to neutralizing mAb b12 and a broadly ... between enhanced HIV entry into macrophages and increased sensitivity to reagents target- ing the CD4 binding site. Here, we use a pa...

Ngày tải lên: 12/08/2014, 23:21

... with predetermined subtype and coreceptor tropism. Subtype was determined by sequencing of the env V3 region, and coreceptor tropism was determined using a phenotypic infection assay with either ... the HIV- 1 coreceptor tropism of subtype A andCRF02_AG.Usingthisassaywefoundahigh amount of HIV- 1 CXCR4-using populations (79%) in our plasma samples and an increasi...

Ngày tải lên: 12/08/2014, 23:23

... (9%), systemic lupus erythematosus (14%), systemic sclerosis (13%), polymyositis/dermatomyositis (14%), and SS Table 3 Correlations with clinical and laboratory parameters of anti-CCP antibody- positive ... partic- ipated in drafting the manuscript. NL participated in the analy- sis and interpretation of data. EB and FB-P contributed to the acquisition of data. RC...

Ngày tải lên: 09/08/2014, 10:23

... infection or inflammation) and HLA-DR on monocytes, and the serum concentrations of IL-6 (a proinflammatory cytokine) and IL-10 in patients with AP to determine whether these markers can identify patients ... response syndrome and then by the compensatory anti-inflammatory response syndrome, which is defined by low human leukocyte antigen (HLA)-DR expression on monocytes...

Ngày tải lên: 13/08/2014, 16:20

... Sall4 isoforms is capable of enhancing and sup- porting primitive hematopoietic cells in the presence of combined cytokine stimulations. Enhanced HSC/HPC activity by forced expression of Sall4 isoforms Next, ... Sall4 isoforms dramatically stimulate multiple known HSC regulators, such as Notch1, HOXB4, cMyc, CyclinD1, CyclinD2, Bmi1, Nfya, Runx 1and Meis1. This is of grea...

Ngày tải lên: 10/08/2014, 21:23

... predominantly Th1-type cytokines [21-24], which could influence t he cytokine milieu within the lung to one which is pro-inflammatory. Interestingly, no difference in cytotoxic ability of the three ... rs and function within the airways. Therefore, in this study we have extended the findings of our previous study to investigate, within induced sputum, the number and...

Ngày tải lên: 12/08/2014, 11:22

... joint [2,4,14]. Gout may occur in any joint including the ankle, knee, hand, wrist, elbow, sacroiliac joint and other joints of the spine, however most commonly occurs in the lower extremity. In ... bony erosions at the radial styloid process and the dorsal rim of the distal radius with soft tissue swelling. These findings were deemed to be consistent with gout...

Ngày tải lên: 25/10/2012, 10:06

... of the peak systolic longitudinal strain between segments with LE ≥ 51% and LE 1-50% 15 . By using the previously proposed cut-off value 15 for strain of –6.5 % a sensitivity of 23 % and ... criticize the intra-individual comparison instead of considering a control group. In our opinion, as the infarct is a regional process, there is no better match than...

Ngày tải lên: 25/10/2012, 11:15

... Diagnosis is usually based on clinical suspicion and physical findings 3 . The latter include blood pressure differenc e between the upper and lower extremities, pulse delay and systolic murmur ... Ascending aortography Figure 2 Descending aortography Discussion Aortic coarctation is a congenital vascular lesion typically diagnosed in early life, accounting for 5...

Ngày tải lên: 25/10/2012, 11:40

... Symptoms leading patients to therapy: X-axis: Symptoms in declinary order. (1) Overall symptoms with- out specification, (2) tachycardia, (3) increase of episodes over the years, (4) anxiety, ... about the nature and quantity of tachycardia and the associated symptoms. Further- more, the effect of symptoms on the patients` daily and social life, especially wi...

Ngày tải lên: 03/11/2012, 11:44