... effects against a vari-ety of viruses, including numerous retroviruses – i.e. HIV,SIV, MLV, HTLV and foamy viruses –, hepatitis B virus and adeno-associated virus (AAV) (for review [11]). In con-trast ... whichaccount for ~30% of each mammalian genome, and theLTR-containing retroelements (including the endogenous retroviruses, ERVs), accounting for ~10% of the genomes and closely related to retroviruses. ... pro-teins might have actually impaired the in vivo amplifica-tion of these elements in the past, by searching for evidence of APOBEC3-editing on the endogenous copiesresiding in the murine and...