Báo cáo khoa học: "Recombinant activated protein C: the key is clinical assessment of risk of death, not subset analysis" potx

... that assessment and it was not part of the data collection. The FDA then recommended the Commentary Recombinant activated protein C: the key is clinical assessment of risk of death, not subset ... having either high or low clinical assessment of risk of death. Unfortunately we do not know what the assessments of risk of death were be...

Ngày tải lên: 12/08/2014, 23:21

... endothelium injury in these conditions, we can ultimately postulate that rAPC is also a therapeutic drug for the endothelium. The earlier the better If rAPC is efficient when infused in the early ... necrosis factor concentrations whereas they remained unchanged in either human septic shock or endotoxemia. The question arises, therefore, as to whether it is truly possible to r...

Ngày tải lên: 13/08/2014, 03:20

... node metastasis in GC [22]. Therefore, c-Met is considered a promsing therapeutic target for this type of cancer [3]. The aim of t his study w as to evaluate the effects of recombinant immunotoxin ... Anti-c-Met/PE38 KDEL induced inhibition of protein synthesis. The ability of IT to inhibit protein synthesis in GES-1, MKN-45 and SGC7901 cells were evaluated by using the...

Ngày tải lên: 10/08/2014, 10:21

... Kit-8 is a colorimetric method in which the intensity of the dye is proportional to the number of the viable cells. Briefly, 200 lL of a suspension of PC-9 cells was seeded into each well of a ... This finding strengthens the possibility that JNK is a mediator of the apoptotic action of AG1478. JNK activity in cells is tightly controlled by both protein kinas...

Ngày tải lên: 18/02/2014, 13:20

... summary of differing definitions found in the trauma literature), the clinical diagnosis of coagulopathy is familiar to most intensivists and surgeons. This is characterized by the clinical assessment ... designed with the intent of being hypothesis- generating and has limitations that deserve comment. It is a post-hoc analysis of the only RCT on the use of r...

Ngày tải lên: 13/08/2014, 03:20

... purposes did not show any sig- nificantly increased risk of thromboembolism after administration of rFVIIa compared with placebo. The mean estimated risk of thromboembolism of 6.42% in the eight ... to the known increased thromboembolic risk of surgical procedures, it is not possible to establish an association with rFVIIa on the basis of the cal- culated mea...

Ngày tải lên: 13/08/2014, 10:20

... effect in other models of ALI. In the previous issue of Critical Care, Waerhaug and colleagues [1] test the hypothesis that inhaled activated protein C (APC), a novel therapy approved for the treatment of ... Research Institute and the Division of Pulmonary and Critical Care Medicine, Departments of Medicine and Anesthesia, University of California, San Francisco, San...

Ngày tải lên: 13/08/2014, 16:20

... from diminishing the enhanced apoptosis of epithelial and other cell populations which accompanies acute lung injury. In the present experiments, treatment with APC was started before the initiation ... diminishing mortality, in patients with acute lung injury and also is likely to prevent the development of lung injury when used as the initial mode of ventilation [11-1...

Ngày tải lên: 13/08/2014, 20:21

... no evidence exists to justify the use of APC in the early stag es of SAP with specific concerns of risk of hemorrhage in patients with prolonged pancreatitis and pancreatic necrosis [16]. Accordingly, ... treatment. The main purpose of this pilot study was to focus on this i ssue, because the increased risk of bleeding with APC has raised concerns [11]. The data from...

Ngày tải lên: 13/08/2014, 21:21

... of the peak to the right in the resulting histogram. In addition, exposure of cells to radiation caused redistri- bution of Bax from the cytosol to the mitochondria without altering the protein expression ... ‘BH3 only’ protein of the Bcl-2 family, in the presence of apoptotic stimuli. The truncated Bid then triggers acti- vation of Bax and ⁄ or Bak and mitoc...

Ngày tải lên: 07/03/2014, 05:20