Báo cáo y học: " Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule mining" pot

... Central Page 1 of 12 (page number not for citation purposes) Retrovirology Open Access Research Discovery of novel targets for multi-epitope vaccines: Screening of HIV-1 genomes using association rule ... particular, the number of synonymous nucleotide substitutions per synonymous site (dS) and the number of nonsynonymous nucleotide substitutions per nonsyn...

Ngày tải lên: 12/08/2014, 23:21

... use of neoepitope antibodies directed toward cryptic amino or carboxyl termini exposed following proteolytic action, as have been successfully applied for the detection of aggrecan and type II collagen ... small leucine-rich pro- teoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases. Glycobiology 2002, 12:...

Ngày tải lên: 09/08/2014, 07:20

... Raymon H, Blease K, Leisten J, Shirley MA, Tang Y, Babusis DM, Chen R, Stirling D, Muller GW: Discovery of (S)-N-[2-[1-(3-ethoxy-4-methoxyphenyl)-2- methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] ... cultured for a further 20 hours before thymidine incorporation was measured. Statistical analysis Two-way analysis of variance (ANOVA), followed by Bonferroni multiple co...

Ngày tải lên: 12/08/2014, 14:22

... lacking both sensitivity and specificity. In the previous issue of Arthritis Research & Therapy, Schwartz and colleagues demonstrated the potential value of urinary TNF-like weak inducer of apoptosis (uTWEAK) ... colleagues demonstrated the potential value of urinary TNF-like weak inducer of apoptosis (uTWEAK) as a biomarker for lupus nephritis (LN) [1]. Renal involvement in s...

Ngày tải lên: 09/08/2014, 14:22

... ) * * log () 2 2 TMM w gk r M gk r gG w gk r gG M Y gk N k k r gk r         where               log ; , 2 Y gr N r w N k Y gk N k Y gk N r Y gr N r Y gr Y gk r gk and YY gr  0. The cases where Y gk =0orY gr = ... can force the DE analysis to be skewed towards one experimental condi- tion. Current analysis methods [6,11] have not accounted for this...

Ngày tải lên: 09/08/2014, 20:21

... Ciona embryogenesis. In the early embryo, 342 out of 380 miRs are expressed, and the ratio drops as embryogenesis proceeds (305 out of 380 in late embryo library). Only 249 out of 380 of the miRs ... new method for the discovery of novel miRNA genes. A computational approach called miRTRAP (miRNA Tests for Read Analysis and Predic- tion) was developed for the systematic pr...

Ngày tải lên: 09/08/2014, 20:21

... Three-point checklist of dermoscopy. A new screening method for early detection of melanoma. Dermatology 2004, 208:27-31. 37. Westerhoff K, McCarthy WH, Menzies SW: Increase in the sensi- tivity for melanoma ... Schin- dera I, Smolle J, Soyer HP, Stolz W: [Diagnostic criteria in epilu- minescence microscopy. Consensus meeting of the professional committee of analytic morphology...

Ngày tải lên: 10/08/2014, 21:23

... than 6 months of service, did not deploy befor e the end of the stud y period, changed military branches dur- ing the study time frame, or received hazardous duty pay but did not deploy to Iraq, ... models were stratified by deployment cohort. For all analyses, a two-tailed alpha cutoff level of ≤0.05 was considered statistically significant. All an alyses were performed using SPS...

Ngày tải lên: 11/08/2014, 16:22

... infusion of a special oxygen quenching dye allowed the visualization of the oxygen distribution on the liver surface using intravital videomi- croscopy. The fluorescence of the dye was directly depend- ent ... together with reduced oxygen availability, decreases cellular high-energy phosphates leading to an early hepatocellular injury and dysfunction. Studies of tis- sue oxygenation...

Ngày tải lên: 13/08/2014, 13:20

... variables Hypothetical pathways for simulation experimentsFigure 2 Hypothetical pathways for simulation experiments. Simple pathway models employed to evaluate the accuracy of the hybrid method ... distribution, and b the rates of the dynamic exchange reactions at the A pathway map of the erythrocyte modelFigure 5 A pathway map of the erythrocyte model. The eryth- rocyte model co...

Ngày tải lên: 13/08/2014, 23:20