Báo cáo y học: "What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine?" ppsx

... purposes) Retrovirology Open Access Review What does the structure-function relationship of the HIV-1 Tat protein teach us about developing an AIDS vaccine? Grant R Campbell 1 and Erwann P Loret* 2 Address: ... inducing conformational changes [43]. Theses mutations between the vaccine and the virus used for the challenge might explain the lack of effic...

Ngày tải lên: 12/08/2014, 23:21

... to HIV-1 and the disease caused by it, AIDS. Many of them are now accessible online. However, we are launching the first Open Access journal in the AIDS arena – AIDS Research and Therapy. The ... to acceptance) of about two months. Authors, together with the Editor/reviewer han- dling the manuscript will be required to declare any com- peting interests. AIDS Researc...

Ngày tải lên: 10/08/2014, 05:20

... o n the m ean hydrophobicity and/or net charge of the natively unfolded polypeptide. In fact, any interaction of such protein with natural ligand affecting mean net c harge and/or mean hydrophobicity ... Instrumentation, Russian Academy of Sciences, Pushchino, Moscow, Russia; 2 Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA, USA Natively unf...

Ngày tải lên: 08/03/2014, 16:20

... gallbladder (lane 6), duodenum and intestine (lane 7) and kidney (lane 8) was used. (A) One band of 324 bp is obtained with the couple of primers NAU764 and NAU726. (B) The efficiency of the cDNA synthesis ... mapping experiments. The last exon is composed of a coding sequence of 193 bp and of an untranslated region of at least 131 bp. The size of the 24 introns ra...

Ngày tải lên: 08/03/2014, 23:20

... interaction of the N-ter- minus of MDM2 with the N-terminus of p53, and an interaction of the acid domain of MDM2 with the central domain of p53 [24]. Accordingly, ligands such as the NUTLIN and BOX1 ... incubated in the presence of the indicated amounts of wild-type MDM2 protein (lanes 2 and 3) or MDM2-C478S protein (lanes 5 and 6) in the absence of AT...

Ngày tải lên: 24/03/2014, 00:21

... transfection analysis of the +4.4a region The +4.4a region containing one of the Y3 cell-specific DHS (Fig. 2B) was highly conserved in rat and humans (Figs 3 and 6) and had the highest enhancing ... region between the B29/Ig-b and GH genes. From the results of footprinting and deletion mutant analysis, a member of the OCT family [29] appeared to be involved in the tra...

Ngày tải lên: 24/03/2014, 03:21

... interchangeably because of the elusiveness of both concepts. Narayanasamy argues that the lack of any authoritative definition of these two terms has resulted in a multiple definition and hence in the ... specifically to avoid a focus on any one religious system or type of spiritual belief. The Royal Free Interview for Religious and Spiritual Beliefs fulfilled most of the...

Ngày tải lên: 08/08/2014, 21:20

... to bypass this defect using a gene therapy approach. Such approaches, while not providing a ‘fountain of youth’, may someday enhance the quality of life of the aged by increasing their resistance ... quality of the humoral response of aged individuals. Study of the GC reaction in healthy aged humans is impractical for obvious reasons. Nonetheless, the products of the...

Ngày tải lên: 09/08/2014, 01:23

... create the WPS-RA and wrote the Introduction and helped with the Discussion section of the manuscript. OP participated in the conceptualization and statistical analysis and in the writing and review ... review of the manuscript. LR wrote sec- tions of the manuscript and reviewed it. All authors read and approved the final manuscript. The authors acknowledge Yves Brab...

Ngày tải lên: 09/08/2014, 14:21

... those of the Korean and Japa- nese HAQs but was higher than the Chinese and Arabic HAQs. For each domain of the Thai HAQ, only the walking domain had an ICC of greater than 0.85. The mean scores of each ... by the advice from the physicians to rest the inflamed joints or the adjustment of nonsteroidal anti-inflamma- tory drugs and/or analgesics, which should take...

Ngày tải lên: 09/08/2014, 14:22