... criterion:Pi$jfðxiÞÀfðxjÞÀÁ2where i $ j means gene i and gene j are adjacent on the training network. Note that f(x) ¼(f(1)(x), f(2)(x), ., f(L)(x))Tand L are the number of features of interest. The test process is ... thesubstrate specificity or serial number [24]. Therefore, a set of enzymes, whose the first three digits of the EC number are the same, are suspected of catalyzing similar reactions.Cloning and gene expressionDNA ... represented by the fourth digit of the EC number is not strongly conserved. Therefore, itis suspected that wrongly annotated genes may havebeen the cause of some of the pathway gaps or missingenzymes....