Báo cáo khoa học: "Optimal management of the high risk surgical patient: beta stimulation or beta blockade" pdf

... included the vast majority of the patients (80% of the cohort). Second, RCRI assess specifically the cardiac risk of the patient, not the mortality related to the surgical procedure. Accordingly, mortality ... was 6% to 7% in the patients with RCRI scores of 3 and more. A high- risk surgical procedure was performed in a minority of the patients, and the...

Ngày tải lên: 12/08/2014, 23:20

... maintain open ≥ 95% of the lung. This required the use of high peak airway pressure (40 to 60 cmH 2 O) with high PEEP levels (25 to 45 cmH 2 O) and the careful selection of the optimal PEEP level ... It is not the mode of ventilation that is important, it is the approach used to apply the mode that is critical! The second issue raised by the Davis and colleagues...

Ngày tải lên: 13/08/2014, 03:20

... only one risk factor had a mortality of 4%, whereas those with two or more risk factors had a mortality of 20%. The single-centre trials utilize their investigators’ intimate knowledge of the strengths ... have to be interpreted in the context of the specific institutions where they are performed. The risks associated with surgery are multifactorial, and the same hi...

Ngày tải lên: 12/08/2014, 23:20

... lower than the metal-containing enzyme. Metal cofactors were incorporated into the enzyme; when the growth medium contained MnSO 4 or FeSO 4 , the activity of the obtained enzymes was 20-fold or six-fold ... plot. Incorporation of metals Metal cofactors were incorporated into the enzyme by one of two procedures. To incorporate metals during growth of bacterial host cel...

Ngày tải lên: 14/02/2014, 22:20

... RNR and that of other class 1 RNRs or, instead, is a result of the interaction of the R2F with the inactivated (oxidized) form of the R1E. We consider the first option unlikely. Under these cir- cumstances, ... may not be considered in the light of the results obtained in the present study. Rather, the involvement of manganese in the in vivo assembly of the...

Ngày tải lên: 15/02/2014, 01:20

... in the absence of Thr [20]. Therefore, a sim- ilar conformational change is expected for these two enzymes, depending on the presence or absence of Thr. In CgAK, mutations of the residues in the ... interior of protein, and the richness of Pro residues mainly contribute to the stabilization of TtAK b. This information might be use- ful for the generation of more...

Ngày tải lên: 18/02/2014, 08:20

... 1. The pCX4bsr expression vectors encoding NS3-4A, NS3, or NS4A from the 1B-1 strain and NS3-4A from the HCV-O strain were used for the transfection. The pCX4bsr expression vec- tor encoding the ... (internal control reporter) and cultured for 42 h, and then poly(I-C) (1 lg) was transfected into the cells for 6 h before the reporter assay as described in the Experimental p...

Ngày tải lên: 18/02/2014, 16:20

... binds to the ribozyme at a rate expected for simple helix formation. In addition, the rate constant for the first step of the TES reaction is more than one order of magnitude lower than the analogous ... that there is room for improve- ment in terms of the rate of reaction. This would be beneficial not so much in terms of the rate of the over- all reaction, as the...

Ngày tải lên: 18/02/2014, 18:20

... reveals that the most similar regions of these proteinases medi- ate interaction of the two b-barrels, formation of the catalytic machinery and structures required for binding of the main chain of the ... pocket of DESC1: Asp189–Gln192 (the basement of the pocket), Ser214–Gly219 (the entrance frame), Lys224– Tyr228 (the back of the pocket) and the disulfide b...

Ngày tải lên: 19/02/2014, 00:20

... established by the incorporation of the b8-strand of one monomer into a b-sheet of the other monomer. The position of the zinc ion is indicated by a circle. (B) Schematic diagram of the dimer. Each ... determines the shape of the active site entry. (e) The structure of the active site is essentially identical with the active sites of the MshB and LpxC p...

Ngày tải lên: 19/02/2014, 00:20