Retrovirology Review BioMed Central Open Access Raltegravir, elvitegravir, and metoogravir: the docx

... resistant to HIV-1 inte- BioMed Central Page 1 of 14 (page number not for citation purposes) Retrovirology Open Access Review Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" ... response the phenyl group at this position was removed and the NH methylated, to confer reduced lipophilicity (and reduced plasma protein binding) but maintain...

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... BioMed Central Page 1 of 2 (page number not for citation purposes) Retrovirology Open Access Correction Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" ... Odde, Kavya Ramkumar and Nouri Neamati: Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors. Retrovirology 2009, 6:25. Since...

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... takes place at the plasma membrane where Gag molecules assemble via interactions between MA and the phospholipids on the one hand, and between NC and the genomic RNA on the other (reviewed in [55]). ... molecules coating the viral RNA and tRNA (NC basic residues and zinc fingers), (iv) the primer tRNALys3 bound to RTp66-p51(in blue), (v) the viral RNA and RT, (vi)...

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... designed and performed the experiments, analyzed the data, and wrote the paper; TM and KA provided clini- cal samples and assembled clinical database. YS and JY provided clinical samples and performed ... and reproduction in any medium, provided the original work is properly cited. Publish with BioMed Central and every scientist can read your work free of charge &...

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... related to the dis- covery of HIV. Since the motivation for the Prize by the Nobel Committee is very limited and the fact that the Committee members cannot comment on how they came to their decision, ... to make the virus isolation possible or to save the virus iso- BioMed Central Page 1 of 9 (page number not for citation purposes) Retrovirology Open Access Comment...

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... isolated and subjected to Northern blotting for TAR sequence. Numbers to the left indicate the size of the RNA ladder in nucleotides. Diagrams to the right show the positions of the wild-type TAR and ... analysis. MH, SF and TM performed and oversaw the microarray experiments. EM, MA, SG and ZB performed the cloning and sequencing of the TAR miRNA. FK over- Ret...

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... formation and enlargement, and membrane merger), the rate-limiting step of the fusion likely lies in these steps. Understanding the kinetics of these processes is therefore critical for the mechanistic study ... by the organization, oligomerization state, and interaction with the membrane lipids and other con- stituents of the cell membrane. Their movement is also direct...

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... including the virus used, the nature of the target cell, and the extent that treatment with low-dose CypA inhibitors increased viral infectivity; and iv) neither the level of expression of CypA nor the ... included in each gel, and the intensities of the CypA bands in the other samples on the same gel are expressed relative to that observed for P4 cells. The result...

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... tat and rev mRNAs, and translation is unaffected. (B) A model for the discrimination between tat, rev and nef mRNAs. The process of splicing used to generate the mRNAs encoding Tat, Rev and ... while the multiply spliced RNAs exit using Nxf1. Once within the cytoplasm, Sam68ΔC interacts with the unspliced, singly spliced and nef mRNAs to block their transla- tion by p...

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... differences in the sample size and the length of the sequences ana- lyzed. Taken together, the data suggest that the expression of hA3G mRNA is associated with the telltale signs of APOBEC3 activity on the ... sequencing, analysis and interpretation of the data and wrote the man- uscript. CEO carried out the statistical analysis and wrote the manuscript. KJT and...

Ngày tải lên: 12/08/2014, 23:20