Báo cáo khoa học: "Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients" pdf

... comparison of the amount of and the kinetics of induction of procalcitonin (PCT) with that of C-reactive protein (CRP) during various types of and severities of multiple trauma, and their relation to ... concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in multiple-trauma patientsHistogram of the day of maximum concentrations of procalcitonin (PCT) and C-reactive protein (CRP) in multiple-trauma ... 1 of 10(page number not for citation purposes)Vol 10 No 1ResearchCorrelation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care...

Báo cáo khoa học: Modulation of glucocorticoid receptor-interacting protein 1 (GRIP1) transactivation and co-activation activities through its C-terminal repression and self-association domains pptx

... vector for estrogen receptor (ER) (B), and MMTV[TRE]-LUC vector for thyroid receptor (TR) (C)] and the NR expression vector [0.15 lg of AR (A), 0.04 lg of ER vector (B) and 0.04 lg of TR vector(C)]. ... compare histo-grams, and lane 2 with lane 8).DiscussionAutoregulation of GRIP1 transactivation activity To date, some of the functions of the N- and C-ter-mini of p160 co-activators were unclear. ... concept that the GRIP1 C-terminal region isinvolved in the modulation of self-transactivation (AD1 and AD2) and co-activator (AR, ER and TR) functionsin HeLa cells. The outcome of the relationship...

Báo cáo khoa học: Induction of translationally controlled tumor protein (TCTP) by transcriptional and post-transcriptional mechanisms pot

... the pat-terns of protein binding to the 5¢-UTR or 3¢-UTR dif-fer signiﬁcantly, although some proteins seem to bind to both; (b) the pattern of 5¢-UTR and 3¢-UTR protein binding of PMA-treated ... the UTRs of TCTP mRNA were able to mediate a stimula-tory effect on luciferase expression under the inﬂuence of dioxin, copper, nickel and cobalt. On the otherhand, PMA and forskolin seem to ... details of the nature of the cis-elements and trans-acting factors involved (RNA-BPs or micro RNAs) and, in particular, the signalingpathway related to the interaction with copper ionsremain to...

Báo cáo khoa học: "Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to

... the protocol, collected data, car-ried out the analyses of suPAR, sTREM-1 and MIF, and wrote the manuscript. OA contributed to the concept of the study, the writing of the protocol and the grouping ... grouping of patients, and helped to draft the manuscript. GK participated in planning of the study and grouping of patients, and helped to draft the manuscript. JE contributed to the planning of the ... number of patients included in the study, the reasons for subsequent exclu-sions, the final diagnoses of the patients, and the ability C-reactive protein (CRP), procalcitonin (PCT), and the three-marker...

Tài liệu Báo cáo khoa học: Characterization of electrogenic bromosulfophthalein transport in carnation petal microsomes and its inhibition by antibodies against bilitranslocase docx

... kA and k0are the inactivation rate constantseither in the presence or in the absence of variousconcentrations of a ligand A, k2 and k1are the rate constants of the inhibition of the bilitranslocase–bilirubin ... related to [bilirubin], according to the Scrutton and Utter equation (see text);k0 and kbrare the inactivation rate constants in either the absenceor in the presence of various concentrations of ... complex and of free bilitranslocase, respect-ively. Kdis the dissociation constant of the apparentbilitranslocase–ligand complex. Figure 5B shows the Scrutton and Utter plot; the value of the...

Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx

... components of the innate host defense, which act through engagement of speciﬁc cell surface receptors and trigger the acti-vation of the janus kinase (JAK) ⁄ signal transducer and activator of transcription ... polyamine in the regulation of apop-tosis [21,22]. Thus, the possibility that the antiviraleffect of spermine is mediated by induction of apop-tosis was analyzed. For this purpose, the effect of spermine ... The lat-ter is in turn used by ODC to produce putrescine, the precursor of spermidine and spermine. To further ana-lyze the regulation of the polyamine-synthetic pathwayin virus infection,...

Báo cáo khoa học: Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways Role of CREB and AP-1 transcription factors doc

... the epitopepeptide tagged to these proteins. Nonetheless, the effectiveexpression of these proteins in the transfected cells furtherdemonstrates the speciﬁcity of RhoA effects. Moreover, the ... p38 and the inhibition of Rho proteins, by the use of C3 toxin, inhibitsthis response selectively [56]. Additionally, the ability of constitutively active forms of the upstream activators of p38, ... lower than the correspondingendogenous proteins. The protein band intensity of Ca-RhoA, Ca-Cdc42 and Ca-Rac is largely dependenton the transfection efﬁciency and/ or the efﬁciency of theirimmunodetection...

Báo cáo khoa học: Photoregulation of DNA transcription by using photoresponsive T7 promoters and clariﬁcation of its mechanism doc

... in thermal stability of the cis form betweenAzo and DM-azo. (A) Illustration of the reversible photoisomeriza-tion of Azo and thermal isomerization of cis-Azo. (B) Quantitativecalculation of ... with UV light in the sin-gle-stranded state to facilitate trans ﬁ cis isomeriza-tion, and then annealed with the template strand to form the duplex. By this approach, 65% of the totalDM-azo was ... isomerized to the cis form, and accord-ingly, about 42% (0.65 · 0.65) of the total wasobtained as the cis–cis form. The other 58% consisted of the trans–trans (  12%), trans–cis ( 23%) and cis–trans...

Báo cáo khoa học: Inactivation of tyrosine phenol-lyase by Pictet–Spengler reaction and alleviation by T15A mutation on intertwined N-terminal arm docx

... the cofactor binding afﬁnity of C. freundii TPL. To verify the effect of the T15A mutation on the cofactor afﬁn-ity, the apparent Michaelis constants for PLP (Km,PLP)with the native and mutant ... N-terminal arm protruding toward the large domain of the other subunit is essential for both the catalytic activity and thermal stability of the enzyme[19–21]. Similarly, the AspAT of Bacillus circulansshows ... view of Pictet–Spengler reaction and cofactorrelease from holo-TPL enzymes. The adductive reaction betweenL-DOPA and pyridoxal-5¢-phosphate (PLP) leads to the depletion of the cofactor in the...

Báo cáo khoa học: Complexes of Thermoactinomyces vulgaris R-47 a-amylase 1 and pullulan model oligossacharides provide new insight into the mechanism for recognizing substrates with a-(1,6) glycosidic linkages docx

... study, the substrates were found bound to these sites in the electron density map. The number of glucose units to bind to the catalytic site and site-N and average B-factor of each glucose unit ... site, and Asp472 forms hydrogen bonds with the O2 and O3atoms of Glc1. The OD1 atom of Asn356 (changedfrom Asp) is positioned to attack the C1 atom of Glc–1 [19]. These structures suggest that the ... protonates the O4 atom (glucoside oxygen) at the hydrolysing site[17,18], and subsequently the OD atom of Asp356attacks the C1 atom of the glucose at subsite )1 [19].Asp472 has been suggested to be...

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