Báo cáo khoa học: " Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate" docx

... biochemical signs of impairment in critical illness. Accordingly, we believe that ethyl pyruvate warrants evaluation in a clinical trial for the prevention and/or amelioration of acute renal failure ... that ethyl pyruvate has anti-inflammatory effects that are independent of its antioxidant properties. Timing of administration of ethyl pyruvate As might be expected fo...

Ngày tải lên: 12/08/2014, 23:20

... ‘motor’ of MOF. Arch Surg 1986, 121:196-208. 2. Dantzker DR: The gastrointestinal tract. The canary of the body? JAMA 1993, 270:1247-1248. 3. Lautt WW: Mechanism and role of intrinsic regulation of hepatic ... delivery. However, proof of improved utilization of oxygen by peripheral tissues, especially in the splanchnic area, is lacking. Silver- man and Tuma [24] reported the absen...

Ngày tải lên: 12/08/2014, 20:20

... The preclinical studies of the effects of beta-2 adrenergic agonists in models of ALI/ARDS open an exciting horizon of therapeutic implications. A limited number of studies of beta agonists in human ... Propagation of ALI can also lead to microthrombosis and impaired fibrinolysis of the micro- vasculature of the acutely injured lung. All of these pathways can lead to furth...

Ngày tải lên: 12/08/2014, 20:20

... expression of TNF-α and IL-1β may interfere with CRH and ACTH synthesis [20]. Primary adrenal failure In sepsis, primary adrenal failure may result from bilateral necrosis and haemorrhage of the adrenals, ... continuous with the sinuses of the medulla, which drain into the central vein of the medulla. The right adrenal vein drains into the inferior vena cava and the left into the ren...

Ngày tải lên: 12/08/2014, 20:20

... elicit transcription of proinflammatory genes. The role of TREM-1 as an amplifier of the inflammatory response has been confirmed in a mouse model of septic shock in which blockade of TREM-1 signalling ... ventilator- associated pneumonia. The presence of elevated levels of sTREM-1 in BAL fluid was the strongest predictor of 488 (LP17) to mimic part of the extracellular doma...

Ngày tải lên: 12/08/2014, 22:22

... from a set of master equations and complete Review Clinical review: Reunification of acid–base physiology John A Kellum The CRISMA (Clinical Research Investigation and Systems Modeling of Acute Illness) ... understanding of pathophysiology will favor one interpretation or the other. For example, the discovery of genetic polymorphisms that alter the function of chloride channel...

Ngày tải lên: 12/08/2014, 22:22

... fourth power of the functional radius of the systemic network (mainly that of the distal resistive arteries). Finally, for a given MAP, SVR depends only on the value of CO, regardless of the way ... correlates of SAP and DAP. Increases in the tone of distal muscular arteries is the landmark of systolic/diastolic hypertension, with increased MAP and essentially unchanged PP bec...

Ngày tải lên: 12/08/2014, 23:20

... positive end-expiratory pressure; WOB = work of breathing. updraft nebulization of bronchodilators in the emergent treat- ment of acute exacerbations of chronic obstructive pulmonary disease. Crit ... duration of therapy [42]. The use of He/O 2 in such circumstances probably requires the use of specific devices that can exploit the properties of He/O 2 during nebulization. T...

Ngày tải lên: 13/08/2014, 03:20

... Page 3 of 5 (page number not for citation purposes) of oxygen taken within 60 seconds [32-34]. Comparisons of these different preoxygenation techniques have often been conflicting, because of the ... years, body mass index > 26 kg/m 2 , lack of teeth, presence of beard, history of snoring) were independent risk factors for DMV, and the presence of two of these criteria in...

Ngày tải lên: 13/08/2014, 03:20

... neutralization of the virus by antibodies. Review Clinical review: Update of avian influenza A infections in humans Christian Sandrock 1 and Terra Kelly 2 1 School of Medicine, University of California, ... [49]. This spread of H5N1 into a wide range of animal and avian species may enhance the spread of the virus into the human population as it interacts with animals in a num...

Ngày tải lên: 13/08/2014, 03:20