... MINIREVIEWPharmacologic chaperoning as a strategy to treat GaucherdiseaseZhanqian Yu, Anu R. Sawkar and Jeffery W. KellyDepartment of Chemistry and The Skaggs Institute for Chemical Biology, ... mechanisms.Proc Natl Acad Sci USA 103, 13813–13818.29 Yu L, Ikeda K, Kato A, Adachi I, Godin G, CompainP, Martin O & Asano N (2006) alpha-1-C-octyl-1-de-oxynojirimycin as a pharmacological chaperone ... lysosomal concentration of partially active GC vari-ants, as demonstrated by increased cellular GC activity, an increased concentration of lysosomal GC glyco-forms and increased colocalization of GC...