Báo cáo khoa học: "Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case control study" pot

... inflam- mation. Open Access Available online http://ccforum.com/content/9/5/R490 R490 Vol 9 No 5 Research Recombinant human activated protein C resets thrombin generation in patients with severe sepsis – a case ... pro-fibrinolytic and anti-inflammatory action of rhAPC when used in severe sepsis, by comparing rhAPC treated patients with case controls...

Ngày tải lên: 12/08/2014, 22:22

... Okajima K, Uchiba M, Horiuchi S, Okabe H: Activated protein C inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappa ... receptor). Acting together with protein S, APC precludes generation of thrombin in a negative feedback loop by proteolytic cleavage of activated factors V and VIII. APC also escala...

Ngày tải lên: 13/08/2014, 11:22

... Kuwabara K, Mikawa K, Nishina K, Shiga M, Maekawa N, Ueno M, Chikazawa Y, Ono T, Hori Y, Matsukawa A, Yoshinaga M, Obara H: Crucial role of group IIA phospholipase A( 2) in oleic acid-induced acute ... and co-administration of recombinant human activated protein C (rhAPC)Changes in pulmonary artery pressure (PAP), right atrial pressure (RAP), and extravascular lung water index...

Ngày tải lên: 13/08/2014, 11:23

... the pathogenesis of sepsis. Treatment with recombinant human activated protein C (rhAPC) has been reported to increase survival from severe sepsis. Protein C levels also decrease markedly in acute lung injury, ... recombinant human activated protein C (rhAPC) in oleic acid-induced nonseptic acute lung injury (ALI) in sheep [1]. Impairment of the protein C p...

Ngày tải lên: 13/08/2014, 11:23

... this article as: Maybauer et al.: Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock. Critical Care 2010 14:R217. Submit ... Open Access Recombinant human activated protein C attenuates cardiovascular and microcirculatory dysfunction in acute lung injury and septic shock Marc O Maybauer 1,2...

Ngày tải lên: 14/08/2014, 07:21

... variance; APACHE: Acute Physiology and Chronic Health Evaluation; APC: activated protein C; AT: antithrombin; CRP: C- reactive protein; DIC: disseminated intravascular coagulation; FDP: fibrinogen degradation ... factor- induced disseminated intravascular coagulation in crab-eating monkeys (Macaca fascicularis). Blood Coagul Fibrinolysis 1997, 8:274-283. 20. Levi M, van der Poll T: R...

Ngày tải lên: 14/08/2014, 08:21

... clinical guidelines and clinical practice. Am J Managed Care 2004, 10(7):481-6. 2. Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR: Why don’t physicians follow clinical practice ... each was assessed separately. Definitions of each characteristic, along with examples of specific interventions felt to reflect each characteristic, are summarized in Table 1. An example of...

Ngày tải lên: 10/08/2014, 10:23

... prophylactic heparin in severe sepsis patients receiving Drotrecogin Alfa (activated) . Crit Care Med 2006, 34 :A1 00. Key messages • Additional anticoagulation in patients receiving RRT during DrotAA ... Small DS: Pharmacokinetic-pharmacodynamic anal- ysis of drotrecogin alfa (activated) in patients with severe sepsis. Clin Pharmacol Ther 2002, 72:391-402. 10. National...

Ngày tải lên: 13/08/2014, 11:23

... factor, inappropriate adrenal response, and early death in patients with severe sepsis. Clin Infect Dis 2007, 44:1321-1328. 13. Chuang CC, Wang ST, Chen WC, Chen CC, Hor LI, Chuang AY: Increases ... probe was: 5' GGCGGCTAGAAATCGGCCTGT. The sequence for the MIF -173 G /C SNP specific sensor probe was: 5' GCTCCAAGCTGTTCTCCAC. The anchor probe was phos- phorylated at the 3&ap...

Ngày tải lên: 18/06/2014, 15:20

... function, the percentage increase in diameter (FMD) after reactive hyperaemia was 9 ± 6, and the percentage increase in diameter after GTN was 23 ± 9. Microvascular and macrovascular endothelial function ... (flow-mediated dilation) and endothelial-independent (glyceryl trinitrate-mediated dilation) macrovascular vasodilatory function. Vasodilatory function was calculated as the percentag...

Ngày tải lên: 12/08/2014, 17:21