Báo cáo khoa học: "Is it time to increase the frequency of use of high-frequency oscillatory ventilation" pps

... sufficientpower to detect extreme differences in outcome betweengroups. This low power was further eroded by the fact thatCommentaryIs it time to increase the frequency of use of high -frequency oscillatory ... factthat the majority of adults must have their spontaneousrespiratory efforts suppressed since their inspiratory flowdemands are often greater than the constant flow of gas in the circuit. This ... Interdepartmental Division of Critical Care Medicine, and Department of Medicine, Division of Respirology, University Health Network,University of Toronto, Toronto, Ontario, Canada2Assistant Professor, Interdepartmental...

Báo cáo khoa học: Is there more to aging than mitochondrial DNA and reactive oxygen species? pot

... membranes[42–44]. The permeability of the mitochondrial innermembrane to OÀ2is one of the factors that determines the accessibility of the agent to mtDNA. Therefore,$ 50% of OÀ2generated ... exhibiting bothperoxidatic and catalatic activities [170]. Neither the effect of truncation or addition of the mitochondrialtargeting sequence on the kinetic properties of the enzyme, nor the ... FEBScaused by accumulation of damage to the mitochon-drial DNA (mtDNA). This narrowed the focus of the theory and resulted in the Mitochondrial Theory of Aging (MTA). Several lines of evidence indirectlyimplicate...

Báo cáo y học: "Is it time for implementation of tight glycaemia control by intensive insulin therapy in every ICU" pdf

... mortality was.As already underlined [7], the mortality rate of the medicalpatients was high. Other local factors could also haveinfluenced the results, thereby questioning the applicability of the ... were used in more thanhalf of the patients. Unequivocally, these two factors reduce the risk of hypoglycaemia and the duration of episodes of hypoglycaemia, a major side effect of IIT. Nonetheless, ... otherintensive care units, but rather argue for the need for large-scaleassessment of the IIT approach by multi-centre studies to confirm the efficacy and safety of this therapeutic modality.In...

Báo cáo khoa học: Concepts and tools to exploit the potential of bacterial inclusion bodies in protein science and biotechnology pdf

... inter-fere with the correct folding of the partner protein thataggregated in a form endowed with biological activity(in the case of DAAO this means also ability to bind the cofactor).In the same ... pointing to a contribution of the free thiolin the pathway leading to the formation of nativebonds [61]. The number of proteins studied up to now is stilltoo limited to try to generalize which structural,sequence ... line, the mostsuccessful techniques are fusion with solubility tags, use of molecular and chemical chaperones and modu-lation of the expression conditions to reduce the rate of protein biosynthesis...

Báo cáo khoa học: "Using Similarity Scoring To Improve the Bilingual Dictionary for Word Alignment" doc

... one of the words . In the ﬁrst step, the algorithm clus-ters the pair of words with the maximum similar-ity score. The new cluster also stores a similarityscore , which in this case is the similarity ... Then the sim-ilarity score of the merged cluster is the aver-age similarity score of the -word cluster, av-eraged with the similarity scores between the single word and all words in the cluster. ... analgorithm that assigns a similarity score to a pair of words . The score is higher for a pair of sim-ilar words, while it favors neither shorter nor longerwords. The algorithm ﬁnds the number of...

Báo cáo khoa học: Hydrogen bond residue positioning in the 599–611 loop of thimet oligopeptidase is required for substrate selection pdf

... ﬁttingdomains I and II to the structure of DcP. The identiﬁcation of the appropriate clipping points was aided by using the Alternate Domain Fit tool from the suite of tools within the swiss-pdbviewer ... carefulanalysis of the role of the conserved Gly residues in the 599–611 loop. The ﬂexibility of the loop provides ameans to bring Tyr612 and Tyr605 into close proxim-ity to the bound substrate, ... the end of the simulation, despite having a close prox-imity between Tyr hydroxyl groups (e.g. 2–3 A˚) and the substrate in the initial model.In addition to reducing the ﬂexibility of the...

Báo cáo khoa học: Using directed evolution to improve the solubility of the C-terminal domain of Escherichia coli aminopeptidase P Implications for metal binding and protein stability pptx

... ZnCl2inhibits the activity of AMPP [1]. Here, the presence of ZnCl2in the dialysis buffer led to the precipitation of each of the three proteins. Neither the intact protein nor the Table 1. ... form of the protein. Subsequent changes to the amino acidsequence were far more effective in improving the solu-bility of the domain. In the case of the AMPP protein, the boundary of the domain ... beresponsible for the inability of the AMPP#3-22 frag-ment to bind metals. From these results, it appearsthat the solubility of the AMPP#4-3 fragment ) or atleast the ability to express this...

Báo cáo khoa học: "An inactivated vaccine to control the current H9N2 low pathogenic avian influenza in Korea" docx

... already begun the use of H9N2 LPAI vaccines. Because of the above mentioned reasons, each of the countries used their own vaccine strains to control the H9N2 LPAI. Based on the properties of AIV, ... inocula.h of incubation, sixof ten eggs infected with the 01310 CE20 virus were dead, whereas, two to three of ten eggs were dead due to the CE15 virus or other less passaged viruses. In spite of increased ... al.According to the 2004 Avian influenza standard operating procedures, Korean animal health authorities permitted the use of the vaccine for LPAI (especially the H9N2 subtype), and the Committee on the...

Báo cáo khoa học: "A pilot study to assess the feasibility of evaluation of markers of response to chemotherapy at one day & 21 days after first cycle of chemotherapy in carcinoma of breast: a prospective non-randomized observational study" potx

... justprior to second cycle of chemotherapy, when patient isavailable in the hospital along with feasibility to evaluatebiomarkers of response to chemotherapy in these biop-sies. The correlation to ... response to the initial regimen.We proposed to explore the change in biomarkers of response to PCT at one day and 21 days after the first cycle of PCT in women with breast cancer attending our institu-tion ... evidence of the efficacy of the chemotherapy inthese patients in eliminating the mitotic fraction. It isintriguing to note that, as soon as 24 hours after chemo-therapy, there was a rise in Ki-67...

báo cáo khoa học: "Efficient selection rules to increase non-linear merit: application in mate selection " pdf

... be to increase the overall merit of the progeny. The selected population will be understood to be finite. Thus, given the phenotypes of thispopulation, the total merit ... limit as the diagonal elements of D go to infinity. Moreover the limiting distribution does not involve Ub. Thus, it is reasonable to use the limitingdistribution to ... of animals in the analysisplus the hypothetical animal. The diagonal element (times the additive genetic variance)corresponding to the hypothetical animal will equal the...

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