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Báo cáo khoa học: "The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study" ppt

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

Tài liệu Báo cáo khoa học: The role of electrostatic interactions in the antitumor activity of dimeric RNases docx

... models or in the surroundings of the mutated residues. The models of RNase A covalent dimers in the exchanging conformation were prepared using the 7RSA structure and the structure of exchanging BS-RNase(1BSR) ... Nter are the C-terminal and N-terminal structural regions,respectively, of the two A and B monomers of the dimeric RNase. The black circle between the monomers indicates the mass center of the dimer.E. ... ª 2006 The Authors Journal compilation ª 2006 FEBS 3693 The role of electrostatic interactions in the antitumor activity of dimeric RNases Eugenio Notomista1, Jose´Miguel Manchen˜o2,...
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Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

Tài liệu Báo cáo khoa học: The role of antioxidants in the cytotoxicity of chemotherapeutic drugs pptx

... undergoes fusion with the membrane of intra-endosomal vesicles contained within MVBs,thereby releasing the nucleocapsid into the lumen of these vesi-cles. Then, the capsid uses these intra-endosomal ... milddevelopmental delay. The protein defective in this disorder is alsoa NHEJ protein. The distinct clinical features of the patients willbe discussed in the context of the protein function.3.4 Diabetes, ... Mutations in the ERCC1 gene induce a distinct set of accelerated ageing features,with a rate of onset depending on the severity of the mutation. The correlation between repair defect severity and clinical...
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Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

Tài liệu Báo cáo khoa học: The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) pptx

... in protein protein interactions with other hydrophilic domains of neighboring integral membrane subunits, and interspeciesinteractions are incompatible.From the co mparative studies with a series of ... the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase) Prasanth Potluri, Nagendra Yadava and Immo E. SchefflerDivision of Biology, Molecular ... histochemical stain in the left panel. Antisera against the SDHC subunit of complex II and against the Rieske protein of complex III revealed the presence of these complexes in all cells (Fig. 3B, right...
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Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx

Tài liệu Báo cáo khoa học: The role of N-glycosylation in the stability, trafficking and GABA-uptake of GABA-transporter 1 Terminal N-glycans facilitate efficient GABA-uptake activity of the GABA transporter pptx

... (2005) 16 2 516 38 ê 2005 FEBS 16 31 The role of N-glycosylation in the stability, trafficking and GABA- uptake of GABA- transporter 1 Terminal N-glycans facilitate efficient GABA- uptake activity of the GABA ... N-linked oligosaccharide side-chainsare important for the GABA transport activity. 1- Deoxymannojirimycin inhibits the GABA- uptake of GAT1 In order to gain further insight into the role of the terminal ... terminal structure of the oligosaccharides facilitate efficient GABA- uptake activity of the GABA transporter. Defective N-glycosylation results in reduction of the stability of GAT1 In order to study the in uence...
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Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf

Tài liệu Báo cáo khoa học: The role of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins pdf

... furtherinvestigate the role of the SEA domain in cleavage of membrane-tethered mucins we carried out site-directedmutagenesis of the FRPG ⁄ SVVV site and evaluatedhybrid mucins in which the SEA ... of the SEA (sea urchin sperm protein, enterokinase and agrin) module in cleavage of membrane-tethered mucins Timea Palmai-Pallag1, Naila Khodabukus1, Leo Kinarsky2, Shih-Hsing Leir1, ... previously. The frag-ments were then cloned into the SpeI ⁄ XhoI sites of the polylinker in MUC1FDTR. The remaining portions of the polylinker introduced leucine and valine residues N-ter-minal to the...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "The Role Of Focussing in Interpretation of Pronouns " pdf

... Processing. Dept. of Computer Science TR-70, Rutgers University, New Brunswick, N.J. Reinhart, T;mya [1976] The Syntactic Domain of Anaphora. unpublished Ph.D. dissertation, Department of Foreign ... and LinBuistics, M.I.T. Rieger, Charles J. [1974] Conceptual Memory: A Theory and Compufer Program for Processing Ihe Meaning Content of Natural Language Utterances. Stanford Artificial Intelligence ... [1979] To,'ards a Computational Thmr 7 of Definite Anaphora Comprehension in £nglish Discour~. unpublished Ph.D. disseration, Electrical Engineering and Computer Science, M.I.T. Webber,...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "The Role of Initiative in Tutorial Dialogue" pdf

... Rules for Assigning Initiative about the effectiveness of Socratic tutoring in theBEE domain or Socratic tutoring in general.3.2 Initiative Annotation MethodThe two definitions of initiative we ... an-notated using changes in initiative as a starting point; thesechanges were taken as marking either a segment endpoint orthe beginning of a nested segment.tion following a question takes initiative. ... dif-ferentiate initiative (which they call dialogue ini-tiative) from task initiative. They define dialogue initiative by stating that it "tracks the lead in de-termining the current...
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Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

Báo cáo khoa học: The role of evolutionarily conserved hydrophobic contacts in the quaternary structure stability of Escherichia coli serine hydroxymethyltransferase pptx

... binding properties The affinity of wild-type and mutant forms for the cofactor was measured to evaluate the impact of the mutations on the structure of the PLP binding site.Because PLP binding ... allowing the proper positioning of the residuesinvolved in PLP binding, substrate binding and modu-lation of the cofactor’s catalytic properties. The thirdcluster forms a hinge between two conserved ... at the value determined from the amino acidsequence (45 320 Da).Measurement of the Kd of PLP bindingequilibriumPLP binding equilibria were analyzed taking advantage of the protein intrinsic...
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Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx

Báo cáo khoa học: The role of interface framework residues in determining antibody VH ⁄ VL interaction strength and antigen-binding affinity pptx

... experimentally the determinant of VH VL interaction strength or itsrelationship with antigen-binding affinity. Previously, the effect of mutations of the VH VL interface residues on antigen binding ... Journal compilation ª 2006 FEBS 2185 The role of interface framework residues in determining antibody VH VL interaction strength and antigen-binding affinity Kenji Masuda1, Kenzo Sakamoto3, ... on the antigen-binding affinity. To investigate systematically thisunsought relationship between the antigen-binding affinity of Fv and the VH VL interaction strength, in the present study...
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Báo cáo khoa học: The role of histones in chromatin remodelling during mammalian spermiogenesis pot

Báo cáo khoa học: The role of histones in chromatin remodelling during mammalian spermiogenesis pot

... for chromatin remodelling during spermatogenesis. (A) Chromatin remodelling combines h istone variants (1) and the histone code ( 2, 3). In the late stages of spermiogenesis, transition proteins ... epigenetic mark involved in chromatin remodelling in postmeiotic male germ cells.Histone variantsFunctional significance of sequence divergence in chromatin remodelling. One of the most distinctivecharacteristics ... active regions [32]. The localization of H 3.3-containing chromatin has not yetbeen determined in mammalian germ cells, but in Drosophila, H3.3 is incorporated in chromatin during firstmeiotic prophase...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx

... FEBS The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors Alexander Faussner1, Alexandra Bauer1, Irina Kalatskaya1, ... agonist[20]. As the internalization is expressed in percentage of total binding, decreasing the binding affinity of the Role of helix 8 and C-termini in bradykinin receptors A. Faussner et al.130 FEBS Journal ... on internalization, i.e. poor signalingwas accompanied by reduced internalization. We sug-gest therefore that helix 8 is directly or indirectly Role of helix 8 and C-termini in bradykinin receptors...
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Báo cáo khoa học:

Báo cáo khoa học: "The role of Bcl-xL and nuclear factor-kB in the effect of taxol on the viability of dendritic cells" ppsx

... 48 h of incubation time (Fig. 2). However, the taxol concentration used was critical for the level of cytokine production; 1 μg/ml of taxol induced only marginal production of these cytokines. ... jooh@jejunu.ac.kr The role of Bcl-xL and nuclear factor-κB in the effect of taxol on the viability of dendritic cellsMi-Hyoung Kim1, Hong-Gu Joo1,2,*1Laboratory of Veterinary Pharmacology, College of ... taxol increased the expression of the anti-apoptotic protein Bcl-xL, and increased the mobilization of p65 subunit molecules into the DC nucleus. Furthermore, we found that the inhibition...
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Báo cáo khoa học:

Báo cáo khoa học: "The role of cardiac troponin I as a prognosticator in critically ill medical patients: a prospective observational cohort study" ppt

... levels of cardiac troponin I (cTnI), a myo-cardial regulatory protein of the thin actin filament, are consid-ered highly sensitive and specific indicators of myocardialinjury [10]. Serial measurement ... variables associated with death. Varia-bles that were associated with mortality in univariate analysiswere considered for inclusion in the model, whereas parame-ters already incorporated into ... recorded.Results Both cTnI positive and negative groups were similar in terms of age, sex and pre-admission co-morbidity. In a univariateanalysis, positive cTnI was associated with increased mortality(OR 7.0,...
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Báo cáo khoa học:

Báo cáo khoa học: "The role of thyroid hormone therapy in acutely ill cardiac patients" pot

... rekindled interest in the use of thyroid hormone therapy in critical illness. Continued improvements in survival after critical cardiac illness provokes the question of whether thyroid hormone therapy ... of thyroid hormone therapy in acutely ill cardiac patientsKathleen L WyneAssistant Professor, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Southwestern ... therapy. That approach has recently beenchallenged in the setting of critical cardiac illness. Researchdemonstrating that thyroid hormone therapy may improvehemodynamic parameters has rekindled...
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Báo cáo y học:

Báo cáo y học: " Time course of plasma gelsolin concentrations during severe sepsis in critically ill surgical patients" pptx

... study does not unequivocally elucidate the role played byFigure 2 Time course of plasma gelsolin levelsTime course of plasma gelsolin levels. Presented are the courses over time of plasma gelsolin ... sepsis via its binding and neutral-izing inflammatory mediators during the course of sepsis. Toour knowledge, this is the first study to examine the time course of plasma gelsolin changes and ... protein that ispart of an 'actin-scavenging' system. Studies suggest that plasma gelsolin may play a crucial role in the pathophysiology of sepsis. Little is known about the course of plasma...
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