Báo cáo khoa học: "Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans, meningitis, or meningococcal disease: a retrospective analysis of patients enrolled in recent clinical studies" ppt

... Indianapolis, IN, USA 7 Clinical Development Associate, Lilly Research Laboratories, Indianapolis, IN, USA 8 Associate Global Medical Information Consultant, Lilly Research Laboratories, Indianapolis, IN, ... http://ccforum.com/content/9/4/R331 R331 Vol 9 No 4 Research Drotrecogin alfa (activated) in patients with severe sepsis presenting with purpura fulminans,...

Ngày tải lên: 12/08/2014, 22:21

Ngày tải lên: 13/08/2014, 03:20

... that a meta -analysis using individual patient data and adjusting for baseline covariates would be an important first step to identify appropriate patients for DrotAA. However, such an analysis would ... selecting a more uniform subgroup of patients with severe sepsis and a high risk of death. In particular, for the subgroup with an APACHE II score of 25 or more...

Ngày tải lên: 13/08/2014, 03:20

... the Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) study [1], Abraham and colleagues assessed the role of DrotAA in patients with severe sepsis and low ... complete a number of phase IV studies evaluating the use of DrotAA in lower-risk patients with severe sepsis, in children with severe sepsis, and i...

Ngày tải lên: 13/08/2014, 03:20

... 344:699-709. 3. Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, Francois B, Guy JS, Bruckmann M, Rea-Neto A, et al., for the Administration of Drotrecogin alfa (activated) in Early Stage Severe ... estimate to the left of the line of identity (1) favors treatment with Drotrecogin alfa (activated) and an estimate to the right favors placebo. A 95% conf...

Ngày tải lên: 13/08/2014, 03:20

... pharmacologic intervention for acute pancreatitis. Death from acute pancreatitis remains a major issue, and late deaths are often related to haemorrhage and are associated with unresolved intra-abdominal ... intra-abdominal sepsis. Drotrecogin alfa, an analogue of endogenous protein C, has antithrombotic, anti-inflammatory and profibrinolytic properties, and it has been shown to reduc...

Ngày tải lên: 12/08/2014, 22:22

... levels in DrotAA-treated patients; °P < 0.05 DrotAA-treated vs. - untreated patients. Values are means ± SEM DrotAA: drotrecogin alfa (activated); GCS: Glasgow Coma Scale; SEM: standard error of ... present in more severe encephalopathy and does not affect mortality. Abbreviations APACHE: Acute Physiology and Chronic Health Evaluation; APC: activated pro- tein C; DrotAA: Dro...

Ngày tải lên: 13/08/2014, 20:21

... Sablotzki A, Arkins N, Utterback BG, Macias WL, Adminis- tration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group: Drotrecogin alfa (activated) for adults with ... ICNARC physiology scores and for patients with two organs failing, as compared with a significant reduc- tion in mortality for higher scores and for patients wit...

Ngày tải lên: 13/08/2014, 10:20

... the neurilemma and perineural cells is visible in MPLI-injected larval brain (as indicated in D with an arrow). Fig. 2. [ 3 H]Dopamine incorporation into MPLI-treated larval brains. Brains were dissected ... times more abundant than that observed in control larvae. Structural changes in MPLI-treated larval brains The dopamine in ux into the MPLI-injected larval brain suggested that...

Ngày tải lên: 23/03/2014, 21:20

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Ngày tải lên: 07/08/2014, 17:22