Báo cáo y học: " Free cortisol levels should not be used to determine adrenal responsiveness" pptx

... Journal Club Section Editor: Eric B. Milbrandt, MD, MPH Journal club critique Free cortisol levels should not be used to determine adrenal responsiveness Aditya Dubey1 and Arthur J. Boujoukos2 ... unnecessary use of glucocorticoid therapy. Commentary The incidence of adrenal insufficiency” in sepsis and septic shock is believed to be between 30 to 70%. Adrenal insufficiency is frequently ... concentrations of serum total cortisol but appropriately elevated free cortisol levels. Measurement of serum free cortisol concentrations will identify patients with normal or even increased adrenal function,...

Báo cáo khoa học: "Drotrecogin alfa (activated) should not be used in patients with severe sepsis and low risk for death" pdf

... thrombosis/stress ulcer prophylaxis ALI/ARDS = Acute lung injury/acute respiratory distress syndrome Recommendation We concur with the ADDRESS authors. DrotAA should not be used in patients with ... subset of ADDRESS subjects. Specifically, DrotAA treated subjects were older and more likely to have multiorgan dysfunction and respiratory failure, making any conclusions about DrotAA’s effectiveness ... Initially designed to include 11,444 patients, the trial was stopped early because of futility after 2,640 subjects were enrolled. Data from 2,613 patients were available for analysis. Control...

Báo cáo y học: "Brain choline concentrations may not be altered in euthymic bipolar disorder patients chronically treated with either lithium or sodium valproate" pps

... they had to be on sodium valproate monotherapy. This was done to examine Bipolar Type I patients in more detail, and to remove a possible confounding variable. All patients had to be euthymic ... Alberta. Healthy controls were examined using adetailed, but non-standardized, psychiatric interview.They were excluded if there was any personal history, orimmediate family history, of psychiatric ... Christopher C Hanstock1 and Peter H Silverstone*2Address: 1Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada and 2Department of Psychiatry, University...

Báo cáo y học: "α Anti-α-fodrin antibodies do not add much to the diagnosis of Sjögren’s syndrome" pot

... to be 60–75% and 30–50%, respec-tively [6–9], while the specificity of particularly anti-Laautoantibodies is generally considered to be reasonablyhigh. Anti-La autoantibodies are mostly found ... La-antigen; hLFS, lymphocytic focus score ≥ 1.0 in sublabial minor salivary glands biopsy. DM, dermatomyositis; Pt, patient; SSc, systemic sclerosis; SLE, systemic lupus erythematosus.IntroductionSjögren’s ... grateful to Dr Y Hayashi (Department of Pathology, Tokushima University School ofDentistry, Tokushima, Japan) for providing us with the α-fodrin cDNAconstruct. We thank Dr W Degen and laboratory technician...

Báo cáo y học: " Chicken cyclophilin A is an inhibitory factor to influenza virus replication" pptx

... from cytoplasm into nucleus. ChCypA expression was not significantly up-regulated by avian influenza virus infection. The present study indicated that chCypA was an inhibitory protein to influenza ... relevance between inhibitoryactivity of chCypA or CypA on influenza virus replica-tion and the regulation potential in cytokines inductionremains to be known.The findings described in our study indicated ... [ 6]. CypA exhibitsan inhibitory activity to influenza virus replication in theearly stage of infection by interfering newly synthesizedM1 protein translocation into nucleus [7].Cyclophilin...

Báo cáo y học: "The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose" pps

... were generally weakly related to the occurrence of arrhythmia and should not be used as the sole criteria for risk assessment in tricyclic antidepressant overdose. Thefrequently recommended ... respect to age, gender, and the amount ingested. To investigate thestrength of the association between a variety of study factorsand arrhythmia, the odds ratio (OR) of exposure to the studyfactor ... thatwere believed to be a more probable cause of the arrhythmiain any of these cases. We have made the assumption that thepurpose of the ECG is to identify patients at risk of any sus-tained arrhythmia,...

báo cáo khoa học: " Safe using messages may not be enough to promote behaviour change amongst injecting drug users who are ambivalent or indifferent towards death" ppsx

... the way people treat you,even your family. It [heroin overdose] would be a good way to go, better than cancer.Peter's narrative points to many factors related to povertyand urban deprivation, ... speed, usually hammer first,then speed. Dropping is really an occupational hazard.When your number's up, your number's up. Why worryabout it. It's just as likely that you'll ... to use a pseudonym to ensure ano-nymity. Participants were asked about overdose patterns,blood-borne virus behaviour, suicidality and attitudestowards death [29-31]. They were specifically...

Báo cáo y học: "More intrinsic parameters should be used in assessing degeneration of articular cartilage with quantitative ultrasound" doc

... intrinsic physical characteristics of cartilage,as reported in this study, should be interpreted more carefully asthey can be affected by many experimental and physical factors. Inthis editorial, ... early diagnosis of degeneration. Sincequantitative ultrasound probes are normally designed to usewith arthroscopy, it is able to access any location of a jointwith a cost of being minimally ... should be consideredcarefully, taking into account the ultrasound measurementsystem and the intrinsic physical properties of the tissue.The ‘signal intensity, echo duration, and interval betweensignals’...

Báo cáo y học: "Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren''''s syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate" pptx

... immunoregulatory and proinflammatory cytokine, hasbeen shown to play an important pathogenic role in Th1-drivenautoimmune disorders. In this study, we evaluated thecirculating levels and salivary-gland ... expressed on mature Th1 but not Th2 lym-phocytes [11]. Furthermore, IL-18 has more recently beenshown to be capable of directly inducing expression ofproinflammatory cytokines such as TNF-α and ... lead to the amplification of the inflammatorycascade.IL-18, although capable of inducing Th2 cytokines in an IL-4 independent manner [7], has been conclusively shown to be a critical regulator...

Báo cáo y học: "Increased serum levels of macrophage migration inhibitory factor in patients with primary Sjögren''''s syndrome" potx

... computer-assisted imaging system(Autoimmun Diagnostika GmbH, Strassberg, Germany),which has been shown to be valid and precise [16].Flow cytometric determination of lymphocyte and monocytesubpopulations ... performed by using an enzyme-linked probe hybridization assay (ELPHA; Biotest, Dreieich,Germany). Sequence-specific oligonucleotide probes were used to determine polymorphic sequence motifs. Hybridiza-tion ... role of MIF as a proinflammatory cytokine inautoimmune diseases [6]. Serum levels of MIF have beenshown to be correlated with the disease activity in severalautoimmune disorders including...

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