Báo cáo y học: "Bench-to-bedside review: Biotrauma and modulation of the innate immune response" pps

... body of evidence in support of the theory that mechanical ventilation may sensitize the innate immune system and that, in turn, the innate immune system may sensitize the lungs to the effects of ... been the subject of a number of reviews [9–14]. The spectrum of VILI includes not only air leaks and increases in endothelial and epithelial permeability, b...

Ngày tải lên: 12/08/2014, 20:21

... closely approximates total effluent flow, the dose of therapy can be quantified in terms of the sum of the ultrafiltrate and dialysate flow rates. Ronco and colleagues [9] randomized 425 critically ... by stratifying 100 consecutive patients based on the BUN at initiation of treatment. ‘Early’ and ‘late’ initiation of therapy were defined by stratifying patients using...

Ngày tải lên: 13/08/2014, 08:20

... contained only by the mouse submandibular small mucin [26]. The consensus sequence of the Muc4 tandem repeat is very close to that of SMC. Nevertheless, the tandem repeat domain of Muc4 does ... transcript of a predicted size of  13 kb. Both human MUC4 and mouse Muc4 genes are virtually identical in terms of the class of introns, the exon number and size of ex...

Ngày tải lên: 08/03/2014, 23:20

... Efficacy assessments (ACR and HAQ-DI) were conducted at weeks 0, 1, 2, and 4 and then q4w until the end of the study or withdrawal; the SF- 36 was administered at weeks 0, 4, and 12 and at the end of the ... significant, except in the 'number of missed days of work' (for the physical functioning domain) and in the 'number of days with outsi...

Ngày tải lên: 09/08/2014, 14:21

... enrolled to test the reliability, validity, and responsiveness of the Thai HAQ, 99 (86.1%) were women. The mean (SD) age was 48.9 (11.9) years, and SRM m ean change of the scoreSD change of the score.= ... Chinese and Arabic HAQs. For each domain of the Thai HAQ, only the walking domain had an ICC of greater than 0.85. The mean scores of each domain of the...

Ngày tải lên: 09/08/2014, 14:22

... diagnosis and the big size of the gallbladder, an open cholecystectomy was decided upon. No other abnormality was identified intra- operatively during the assessment of the peritoneal cavity, including ... drafting of the manuscript, and critically revised the manuscript. EP carried out the histopathologic evaluation, contributed to organising and drafting of the...

Ngày tải lên: 11/08/2014, 17:21

... stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase (GCS) is blocked by L-buthionine-(S,R)-sulfoximine ... hours of hyperoxia (relatively early events). Following 24 hours of hyperoxia, however, NF-κB activation and increased levels of TNF-α mRNA were pre...

Ngày tải lên: 12/08/2014, 19:21

... kidneys [48]. In other organs, VEGF gene expression is induced by hypoxia and by cytokines. To identify the cellular mechanisms in control of tubular VEGF production, the effects of hypoxia and ... regulation of TNF- αα biosynthesis: augmentation by irreversible inhibition of gamma-glutamylcysteine synthetase and the involvement of an I κκ B- αα /NF- κκ B-independent pat...

Ngày tải lên: 12/08/2014, 19:21

... Functionally, the V 1 R activates G- proteins of the G q/11 family. The α-subunits regulate the activ- ity of the β-isoforms of phospholipase C [29]. A variety of signaling pathways is associated ... probably related to a polymorphism of the platelet V 1 R [49]. V 1 Rs are found in the kidney, where they occur in high density on medullary interstitial cells, vasa rect...

Ngày tải lên: 12/08/2014, 19:22

... study the effects of vasopressin on the heart independently of coronary blood flow, the effects of vasopressin on inotropy were strikingly different. By main- taining constant coronary flow, the ... vasodilatory shock states by blunting the increase in cGMP that is induced by NO [28] and ANP [29], and by decreasing the synthesis of inducible nitric oxide synthase (NOS)...

Ngày tải lên: 12/08/2014, 19:22