Báo cáo y học: "Bench-to-bedside review: Biotrauma and modulation of the innate immune response" pps
Báo cáo y học: "Bench-to-bedside review: Biotrauma and modulation of the innate immune response" pps
... body of evidence insupport of the theory that mechanical ventilation maysensitize the innate immune system and that, in turn, the innate immune system may sensitize the lungs to the effects of ... been the subject of a number of reviews [9–14]. The spectrum of VILI includes not only air leaks and increases inendothelial and epithelial permeability, but also increases inpulmonary and systemic ... publication of this work [1] we noticed the following errors: The surname of the first author was incorrectly written as‘Yamenel’ and should be ‘Yamanel.’ In the Study Protocol section of the materials...
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Báo cáo y học: " Clinical review: Timing and dose of continuous renal replacement therapy in acute kidney injury" ppsx
... closely approximates totaleffluent flow, the dose of therapy can be quantified in terms of the sum of the ultrafiltrate and dialysate flow rates. Ronco and colleagues [9] randomized 425 critically ... by stratifying 100 consecutivepatients based on the BUN at initiation of treatment. ‘Early’ and ‘late’ initiation of therapy were defined by stratifyingpatients using the BUN at initiation of ... indication for therapy and outcome isnot known. Most importantly, the design of all four of thesestudies limited analysis to patients who received renalreplacement therapy, ignoring the subset of patients...
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Báo cáo Y học: Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4 pdf
... contained only by the mousesubmandibular small mucin [26]. The consensus sequence of the Muc4 tandem repeat isvery close to that of SMC. Nevertheless, the tandem repeatdomain of Muc4 does ... transcript of apredicted size of 13 kb. Both human MUC4 and mouseMuc4 genes are virtually identical in terms of the class of introns, the exon number and size of exons. The sizes of the 24 mouse ... 3153Restriction mapping of the BAC clone and Southern blot analysesTheBACwasdigestedtocompletionwiththerestrictionenzyme NotI. For each of the other restriction enzymesused, one part of this NotI-digested...
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Báo cáo y học: "Discriminant validity, responsiveness and reliability of the rheumatoid arthritis-specific Work Productivity Survey (WPS-RA)" potx
... Efficacy assessments(ACR and HAQ-DI) were conducted at weeks 0, 1, 2, and 4 and then q4w until the end of the study or withdrawal; the SF-36 was administered at weeks 0, 4, and 12 and at the end of the ... significant, except in the 'number of missed days of work' (for the physical functioning domain) and in the 'number of days with outside help' for the bodily pain and mental health ... create the WPS-RA and wrote the Introduction and helped with the Discussion section of the manuscript. OPparticipated in the conceptualization and statistical analysis and in the writing and review...
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Báo cáo y học: "Comprehensibility, reliability, validity, and responsiveness of the Thai version of the Health Assessment Questionnaire in Thai patients with rheumatoid arthritis" potx
... enrolled to test the reliability,validity, and responsiveness of the Thai HAQ, 99 (86.1%)were women. The mean (SD) age was 48.9 (11.9) years, and SRM m ean change of the scoreSD change of the score.= ... Chinese and ArabicHAQs. For each domain of the Thai HAQ, only the walkingdomain had an ICC of greater than 0.85. The mean scores of each domain of the Thai HAQ and total scores in the secondadministration ... faucets, and containers) and footwear and improvement of fabric quality (for the wring cloth item) mayhelp improve the patient's ability to perform the activities in the grip and walking...
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Báo cáo y học: "Undifferentiated giant cell type carcinoma of the gallbladder with sarcomatoid dedifferentiation: a case report and review of the literature" ppsx
... diagnosis and the big size of the gallbladder, an open cholecystectomy wasdecided upon. No other abnormality was identified intra-operatively during the assessment of the peritoneal cavity,including ... drafting of the manuscript, and critically revised the manuscript. EP carried out the histopathologic evaluation,contributed to organising and drafting of the manuscript, and critically revised the ... acquisi-tion of data, drafting and writing of the manuscript. APcontributed to the preoperative and postoperative man-agement of the patient and to critical review of the manuscript. GA and HG carried...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase (GCS) isblocked by L-buthionine-(S,R)-sulfoximine ... hours of hyperoxia (relativelyearly events). Following 24 hours of hyperoxia, however,NF-κB activation and increased levels of TNF-α mRNA werepresent in pulmonary lymphocytes. By 48 hours of hyperoxia, the ... changes in the physiologic processes of many tissues and activates inflammatory cascades that include the activa-tion of stress transcriptional factors and the upregulation of cytokine synthesis....
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... kidneys [48]. In otherorgans, VEGF gene expression is induced by hypoxia and bycytokines. To identify the cellular mechanisms in control of tubular VEGF production, the effects of hypoxia and ... regulation of TNF-ααbiosynthesis: augmentation by irreversible inhibition of gamma-glutamylcysteine synthetase and the involvement of an IκκB-αα/NF-κκB-independent pathway in alveolar epithelialcells. ... irreversibleinhibitor of γγ-glutamylcysteine synthetase, augments LPS-mediated pro-inflammatory cytokine biosynthesis: evidencefor the implication of an IκκB-αα/NF-κκB insensitive pathway. EurCytokine...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 1 – receptor physiology" doc
... Functionally, the V1R activates G-proteins of the Gq/11 family. The α-subunits regulate the activ-ity of the β-isoforms of phospholipase C [29]. A variety of signaling pathways is associated ... probably related to a polymorphism of the plateletV1R [49].V1Rs are found in the kidney, where they occur in high densityon medullary interstitial cells, vasa recta, and epithelial cells of the ... receptors, and the P2class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions of vasopressin on the vascular...
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Báo cáo y học: "Science Review: Vasopressin and the cardiovascular system part 2 – clinical physiology" pps
... study the effects of vasopressinon the heart independently of coronary blood flow, the effects of vasopressin on inotropy were strikingly different. By main-taining constant coronary flow, the ... vasodilatory shock states by blunting the increase in cGMP that is induced by NO [28] and ANP[29], and by decreasing the synthesis of inducible nitric oxidesynthase (NOS) that is stimulated by lipopolysaccharide ... by a variety of neuro-transmitters and hormones; these interact with a network of signal transduction pathways that ultimately affect contractil-ity either by affecting calcium levels in the...
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