Báo cáo y học: "Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility" pptx
Báo cáo y học: "Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility" pptx
... should ever bestopped for futility.ReviewPro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futilityDavid A Schoenfeld1and ... debate the role of futility-stopping rules.Keywords clinical research, futility, interim analysis, randomized controlled trials, stopping rulesThe scenarioPro: Futility stopping can speed up ... been stopped at interim analysis for futility. Although you have not yet seenthe results, this cessation concerns you because you wereanxiously awaiting the results of these trials since you...
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Báo cáo y học: "Illustrating risk difference and number needed to treat from a randomized controlled trial of spinal manipulation for cervicogenic headach" ppsx
... that are notreflected in the odds ratio, a statistic often reported for binary data [5,7].Clearly, binary analysis is appropriate with naturallydichotomous variables, such as cure or death. ... withmissing data imputed [11]. Five subjects were eliminatedfrom this analysis due to lack of follow-up after baseline. For this secondary analysis, the continuous outcomeswere dichotomized with ... Interstudy's Low Back Pain TyPESpecification instrument [28].Statistical analysis An intention -to- treat analysis was conducted with eachparticipant included in the original allocation group withmissing...
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Báo cáo Y học: Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts A role for phosphoinositide 3-kinase pot
... PAR2.In summary, this study has demonstrated that duoden-ase induces DNA synthesis in pulmonary artery fibro-blasts and that this response may be mediated by anatypical PAR, either an i soform of ... duodenase is capable of cleaving certainsubstrates with trypsin-like primary specificity, we initiallyhypothesized that induction of DNA synthesis by duoden-ase is mediated through a PAR2 mechanism.Surprisingly, ... jejenum is mitogenic for bovinepulmonary artery fibroblasts and this effect is dependenton the direct proteolytic activity of th is enzyme.As the PARs d escribed to date are activated by cleavageof...
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Báo cáo y học: "The acute management of trauma hemorrhage: a systematic review of randomized controlled trials" ppsx
... to berecruitedExpectedend dateCRISTAL: Colloids versus crystalloids for resuscitation of critically illpatientsITU patients, fluidresuscitationColloids Crystalloids 28 daymortality3,010 ... Dentistry, Queen Mary University of London, London, E1 4NS,UK.Authors’ contributionsNC contributed to study design, acquisition of data, analysis andinterpretation of data, drafted and revised ... [56].There are limitations to this review. A quantitative analysis was not possible because of the heterogeneitybetween studies. For example, the inclusion criteria for patients varied widely, such as...
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Báo cáo y học: "(Sub)clinical cardiovascular disease is associated with increased bone loss and fracture risk; a systematic review of the association between cardiovascular disease and osteoporosis" ppsx
... Hydro-lysis of pyrophosphate, which is an inhibitor of hydro-xyapatite formation, is especially needed to facilitatenormal mineralisation [99]. In vitro studies in VSMC’sshowed that the ALP ... 16:64-70.54. Yamada S, Inaba M, Goto H, Nagata-Sakurai M, Kumeda Y, Imanishi Y, Emoto M, Ishimura E, Nishizawa Y: Associations between physical activity,peripheral atherosclerosis and bone status in ... pro-inflammatory cytokines are shown to elevate OPG levels in patients with CV disease [113].Thus, while OPG appears to play a role in the patho-gene sis of atherosclerosis, the exact mechanism remainsto...
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Báo cáo y học: " Improving surgical outcomes: it is the destination not the journey" ppt
... hemodynamic optimization: relationship to methodological quality. Crit Care 2005, 9:771-779.3. Abbas SM, Hill AG: Systematic review of the literature for the use of oesophageal Doppler monitor ... intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial. Crit Care 2010, 14:R18.7. ... postoperative morbidity [1], which in the control group was similar to other studies investigating high-risk patients. A relatively homogeneous study group has been investi gated; and...
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Báo cáo y học: "Expression of ADAM15 in rheumatoid synovium: up-regulation by vascular endothelial growth factor and possible implications for angiogenesis" ppt
... negligi-Figure 4In situ hybridization of ADAM15 in rheumatoid arthritis synovial tissuesIn situ hybridization of ADAM15 in rheumatoid arthritis synovial tissues. Paraffin sections were reacted with digoxigenin-labeled ... possibility that ADAM15 is involved in angiogenesis in RA synovium.IntroductionIn rheumatoid arthritis (RA), the affected joints develop chronicsynovitis that is characterized by hyperplasia ... inflammatorycytokines by macrophages [57] and stimulate monocytes andT cells [58]. Thus, these data suggest that ADAM15 may playa role in the aggravation of inflammation of RA synovitisthrough...
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Báo cáo y học: "An ethnobotanical survey of plants used to manage HIV/AIDS opportunistic infections in Katima Mulilo, Caprivi region, Namibia" ppt
... programmes discourage the use of traditional med-icines, fearing that the efficacy of antiretroviral drugsmay be inhibited by traditional medicines, or that theirinteractions could lead to toxicity ... tra-ditional medicines can also lead to a discontinuation ofART therapy [33]. Thus many African governmentsincluding Namibia still have contradictory attitudestowards traditional medicines for ... to formulate policies and legislation to regulate these mat-ters. A Bill on ABS has been drafted but is yet to beenacted into law because technical questions relating to its implementation remain unanswered...
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Báo cáo y học: "Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report" pptx
... the treatment course.DiscussionEccrine porocarcinoma is challenging to diagnose basedon clinical presentation alone, and histopathologicalexamination is almost always required. Typically, aFigure ... parotidectomy with facial nerve preservation and cer-vical lymphadenectomy. Surgical pathology specimensrevealed a moderately differentiated carcinoma withgrowth pattern and morphological features ... EPCwith secondary metastasis to the parotid gland who wastreated with intensity-modulated radiation therapy aftersurgical resection.Case PresentationA 76-year-old Caucasian man presented with...
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Báo cáo y học: " REFLEX, a social-cognitive group treatment to improve insight in schizophrenia: study protocol of a multi-center RCT" pptx
... Cognitive-behavioural therapy for refractory psychotic symptoms of schizophreniaresistant to atypical antipsychotic medication: Randomised controlled trial. British Journal of Psychiatry 2005, ... Leeuwarden. Patients who partici-pate in the fMRI study will be randomized separately.3. Statistical analysis 3.1 Behavioral data Analysis will be performed according to the intention to treat principle. ... associated with a heavy stigma.Thereisevidencethatsomepatientscopewiththethreat that stigma poses to their self-esteem by denyingthe illness [39,40].Psychological defensiveness in psychosis is...
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