... Corwin HL, Gettinger A, Rodriguez RM, Pearl RG, Gubler D, EnnyC, Colton T, Corwin MJ: Efficacy of recombinant human ery-thropoietin in the critically ill patient: a randomized, double-blind, placebo-controlled ... function. Physiol Rev 1992, 72:449-489.9. Jelkmann WE, Fandrey J, Frede S, Pagel H: Inhibition of erythro-poietin production by cytokines. Implications for the anaemiainvolved in inflammatory states. ... cost-efficacy of thisapproach is not certain.EPO is an essential growth factor for erythropoiesis; the stim-ulus for induction of EPO gene expression is a reduction in blood oxygen availability [8]...