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Báo cáo y học: " Bench-to-bedside review: The role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury" pps

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Báo cáo y học: "Systematic review: Intra-aortic balloon counterpulsation pump therapy: a critical appraisal of the evidence for patients with acute myocardial infarction" doc

... werehemodynamic instability necessitating the use of an IABP,cardiogenic shock, bleeding diathesis prohibiting the use of aspirin or heparin, precatheterization administration of thrombolytic therapy, ... partialreperfusion of the IRA. Rescue angioplasty was notattempted in any of these patients. This study randomizedpatients at the end of initial coronary angiography to 48 h of prophylactic IABP therapy (n ... sen-sitivity analysis was not used to assess the robustness of the conclusions. In determining the clinical application of an economic anal-ysis, clinicians determine whether the results are useful in practice....
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Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx

... occur in the setting of infection, and it is possible that the primary geneticlesions in autoimmunity involve components of the samesystem that induces cytokine production in the course of aninfection. ... presence of aninfection. The effector limb of the responseDuring the decade of the 1980s, one of the key discoveries in sepsis research concerned the role played by soluble mediators of monocyte/macrophage ... observed in septic shock. In part, they do so bytriggering the release of many secondary cytokines, includ-ing IL-6, and numerous chemokines, which may further con-tribute to the septic syndrome.It...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf

... infiltration into the lungs and toincreased pulmonary proinflammatory cytokine expression [7].However, the initial events induced by hyperoxia, therebyleading to acute inflammatory lung injury, remain ... phosphorylation.Anti-inflammatory cytokine-mediated oxidant injuryAnother anti-inflammatory cytokine that is involved as a reg-ulatory element in lung injury is IL-11. For instance, the role of ... [26–37]. In amurine hyperoxia model, the effects of lisofylline on the activa-tion of NF-κB and CREB, on the expression of proinflamma-tory cytokines in the lungs and on the circulating levels of oxidized...
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Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx

... lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IκκB-αα/NF-κκB-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolar epithelium. ... February 2003 Vol 7 No 1 Haddad50DNA binding. In hypoxia, cytokines strongly increased HIF-1activity compared with the effect of hypoxia alone. Only IL-1βincreased HIF-1α protein levels. In transient ... tubules of inflamed kidneys but not in normal kidneys [48]. In otherorgans, VEGF gene expression is induced by hypoxia and bycytokines. To identify the cellular mechanisms in control of tubular...
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Báo cáo y học: "Clinical review: The role of the intensive care physician in mass casualty incidents: planning, organisation, and leadership" pot

... Capacity (including staffing)How do we ensure that security (including checking of staff identity) is maintained?Who is the lead intensivist and who is the senior nurse? Are their roles clearly ... explosive-type disaster yields low numbers of critically injured patients, over-triage is likely to be a problem,with the attendant risk of increasing overall mortality [12]. On the day of the bombings, ... to the ICU.ReviewClinical review: The role of the intensive care physician in masscasualty incidents: planning, organisation, and leadershipPeter J Shirley and Gerlinde ManderslootRoyal...
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Báo cáo y học: "Clinical review: The role of biomarkers in the diagnosis and management of communityacquired pneumonia" potx

... appropriate ther-apy, and use of the procedure will probably become the standard of care in the next few years.Indicators of prognosisCAP is the leading cause of death from infection in west-ern ... surprisingly poor predictors for the diagno-sis of CAP.  e added value of the PCT biomarker as a clinical decision-making tool is evidenced in the present study and many other studies involving ... study, each point increment in the International Society of  rombosis and Hemostasis DIC score increased the odds ratio for 28-day mortality by 1.25.  e pattern of coagulation activation may...
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Báo cáo y học: "Clinical review: What is the role for autopsy in the ICU" doc

... of the growing impact of the opinions of patients and their relatives, physicians are often forced to discuss necropsy with them. As a result, the autopsy rate in France has markedly declined ... ICU.Autopsies allow the accuracy of existing diagnostic tools to be checked. One example may clarify this matter.  e role of Candida spp. in the airways of critically ill patients was examined in a prospective, ... 32% in the 1980s, and an increase in undiagnosed infections of 30%. Gerain and colleagues [36] studied the causes of death in oncology patients who died in an ICU. In 23.5% of all deaths the...
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Báo cáo y học: " Meta-review of the effectiveness of computerised CBT in treating depression" pps

... Embase, CINAHL(EBSCO), the British Nursing Index, the CochraneLibrary, and PsycINFO. All systematic reviews examiningefficacy of cCBT for depression with or without anxiety in adults were included ... the outset, limited to the lastten years (initially search ing 1999 to 2009 , then updatingto Feb 2011). The evolutionary development of cCBTand its reliance on ever-increasing speeds of internetcommunic ... cCBTfor depression. They include other uses of the internet(e.g. for screening and educating), other interventions (e.g.internet based therapies), other health problems (e.g. anxi-ety and pani c...
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Báo cáo y học: "Systematic review: The relation between nutrition and nosocomial pneumonia: randomized trials in critically ill patients" doc

... gastric contents has not beenconvincingly demonstrated, these trials are in keepingwith the gastropulmonary route of infection. The gastropulmonary route of infection is a concept atleast two ... significantlyhigher in samples obtained while patients were supinethan when they were semirecumbent. In another study,scintigraphic evidence of esophageal reflux was found in 81% of patients in the ... [23], in another study the pneumonia rate was significantly lower in the enteralnutrition group [24], and in the remaining two studies, the pneumonia rate was slightly higher in patientsreceiving...
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Báo cáo y học: "Science review: Role of coagulation protease cascades in sepsis" ppt

... (pericytes, cardiomyocytes, smoothmuscle cells, keratinocytes) and by vascular monocytes andendothelial cells upon induction by inflammatory cytokines orendotoxin [3]. TF is the high-affinity ... increas-ing preclinical and clinical evidence that proteases of the coagulation system affect the inflammatory response, inde-pendent of their role in initiating and controlling blood clot-ting. Here, ... coagulation pathways[29]. Taken together, these findings strongly suggest that the initiation phase of the coagulation pathways can sustain aninflammatory lethal response, independent of the downstreameffector...
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