Báo cáo y học: " Science review: Searching for gene candidates in acute lung injury" pot
Báo cáo y học: " Science review: Searching for gene candidates in acute lung injury" pot
... Grigoryev et al.
Table 2
Candidate genes in acute lung injury
Gene Ontology PubMatrix terms
Encoded protein Gene symbol NR IM CT IN BC Lung Lung injury
Interleukin-1β IL1B × × × 1536 287
Interleukin-6 ... of inducible cyclo-oxygenase-2. Upregulation of the
cyclo-oxygenase-2 gene is also linked to increased pulmonary
microvascular permeability during combined burn and smoke
inh...
Báo cáo y học: "Histone deacetylase inhibitor, butyrate, attenuates lipopolysaccharide-induced acute lung injury in mice" pptx
... butyrate, a HDAC inhibitor, on lipopolysaccharide (LPS)-induced
acute lung injury (ALI) in mice.
Methods: ALI was induced in Balb/c mice by intratracheally instillation of LPS (1 mg/kg). Before ... observed in lung epithelial cells,
HDAC inhibitors seemed to be pro-inflammatory in
ALI. In the present study, interestingly, our results indi-
cated that administration of butyrate...
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf
... affecting
its phosphorylation.
Anti-inflammatory cytokine-mediated oxidant injury
Another anti-inflammatory cytokine that is involved as a reg-
ulatory element in lung injury is IL-11. For instance, the ... hyperoxia activates
NF-κB in the lungs before any increase in proinflammatory
cytokine protein occurs, and they further suggest that NF-κB
activation may represent an initial eve...
Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: α role for hypoxia-inducible factor-1α" pptx
... February 2003 Vol 7 No 1 Haddad
50
DNA binding. In hypoxia, cytokines strongly increased HIF-1
activity compared with the effect of hypoxia alone. Only IL-1β
increased HIF-1α protein levels. In transient ... the potential signaling pathways involved in
cytokine-mediated regulation of hypoxia-induced hypoxia-inducible
factor-1α (HIF-1α) translocation and activation. Hypoxia and
inflammat...
Báo cáo y học: "Science review: Role of coagulation protease cascades in sepsis" ppt
... (pericytes, cardiomyocytes, smooth
muscle cells, keratinocytes) and by vascular monocytes and
endothelial cells upon induction by inflammatory cytokines or
endotoxin [3]. TF is the high-affinity cellular ... efficacy in providing anti-inflammatory benefit in sepsis. Anticoagulants (shown in red and boxed)
showed preclinical efficacy in preventing lethality, whereas anticoagulant mecha...
Báo cáo y học: " Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors" ppsx
... within the past
4 years in our understanding of how cytokine storm is elicited
during severe infection offer a good deal of promise. Although
success in treating sepsis with individual cytokine inhibitors
has ... the primary genetic
lesions in autoimmunity involve components of the same
system that induces cytokine production in the course of an
infection. Here, too, forward genetic m...
Báo cáo y học: "Science review: Mechanisms of ventilator-induced injury" pps
... ventilation in patients with ARDS and acute lung injury.
Keywords acute lung injury, acute respiratory distress syndrome, alveolar epithelium, mechanical ventilation,
ventilator-induced lung injury
237
that ... online http://ccforum.com/content/7/3/233
Table 2
Clinical definition of acute respiratory distress syndrome and acute lung injury [76]
Clinical feature Acute res...
Báo cáo y học: "Science review: Cell membrane expression (connectivity) regulates neutrophil delivery, function and clearance" docx
... secondary to inflammatory
cytokines may be diminished in elderly persons [151]. In addi-
tion, inflammatory mediators may alter intracellular factors
within neutrophils in order to delay apoptosis; ... interventions that yield a reduction in neu-
trophil-mediated inflammatory injury in one organ may predis-
pose to infection at other sites. Genetic factors are clearly
involved in...
Báo cáo y học: "Science review: Apoptosis in acute lung injury" potx
... the pathogenesis of
acute lung injury in humans. The first of these, namely the ‘neutrophilic hypothesis’, suggests that
during acute inflammation the cytokines granulocyte colony-stimulating factor ... on the main modulatory steps that
are candidates for therapeutic intervention.
Review
Science review: Apoptosis in acute lung injury
Gustavo Matute-Bello
1
and Thomas R M...
Báo cáo y học: "Science review: Genetic variability in the systemic inflammatory response" pdf
... +250
GG genotype, again suggesting that polymorphisms may be
‘good’ or ‘bad’, depending on the outcome of interest.
Interleukin-1
αα
and interleukin-1
ββ
IL-1, a potent proinflammatory cytokine released ... polymor-
phisms with potential influences on the inflammatory
response have been identified in a variety of antigen recogni-
tion pathways, proinflammatory cytokines, and anti-inflamma-...
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