Báo cáo y học: "Science review: Extracellular acidosis and the immune response: clinical and physiologic implications" potx

... review: Extracellular acidosis and the immune response: clinical and physiologic implications John A Kellum 1 , Mingchen Song 2 and Jinyou Li 3 1 Associate Professor, Critical Care Medicine and ... understanding of the relationship between pH o and the synthesis and release of inflammatory molecules. Investigators continue to seek means to modulate the inflam...

Ngày tải lên: 12/08/2014, 20:20

... inflammatory response is dictated by a variety of factors, including the pathogenicity and duration of the stimulus, and the balance between the proinflammatory and anti-inflammatory response. ... predominantly vascu- lar diseases, and the study conducted by Marshall and col- leagues [57] suggests that the renin–angiotensin system may play a key role in the pathogenesi...

Ngày tải lên: 12/08/2014, 19:22

... (pericytes, cardiomyocytes, smooth muscle cells, keratinocytes) and by vascular monocytes and endothelial cells upon induction by inflammatory cytokines or endotoxin [3]. TF is the high-affinity cellular ... systems [21]. Physiologically relevant primary endothelial cells express both PAR1 and PAR2 but, unlike the finding in heterologous expression systems, APC selectively activates...

Ngày tải lên: 12/08/2014, 19:21

... circulatory system, exiting only when they are summoned by signals that emanate from the extravascular compartment. Other cells of the innate immune system, including the macrophage and the dendritic cell, ... septic shock. In part, they do so by triggering the release of many secondary cytokines, includ- ing IL-6, and numerous chemokines, which may further con- tribute to th...

Ngày tải lên: 12/08/2014, 19:21

... partial pressure for oxygen to the fraction of oxygen in the inspired air. 240 lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl ... patients for the recent randomized, controlled Acute Respiratory Distress Syndrome Network study. The patients who meet the clinical criteria of the current definition therefore b...

Ngày tải lên: 12/08/2014, 19:21

... infiltration into the lungs and to increased pulmonary proinflammatory cytokine expression [7]. However, the initial events induced by hyperoxia, thereby leading to acute inflammatory lung injury, remain ... anti-inflamma- tory therapy for CF lung disease and could possibly promote clearance of secretions in the CF airway in a NF-κB- dependent manner. Hyperoxia (hyperbaric levels of...

Ngày tải lên: 12/08/2014, 19:21

... kidneys [48]. In other organs, VEGF gene expression is induced by hypoxia and by cytokines. To identify the cellular mechanisms in control of tubular VEGF production, the effects of hypoxia and ... γγ -glutamylcysteine synthetase, augments LPS- mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an I κκ B- αα /NF- κκ B insensitive pathway. Eur Cytokine...

Ngày tải lên: 12/08/2014, 19:21

... that exhibit specificity for both the type of leukocyte on which they are expressed and the ligand to which they bind. The specificity of chemoattractant-induced leukocyte chemotaxis is related ... myeloid stem cells; the myeloblast differentiates into the promyloblast, and then into the myelocyte. These cells differ- entiate into metamyelocytes as well as segmented band neu-...

Ngày tải lên: 12/08/2014, 19:21

... neutrophils and release of cytokines by macrophages The third mechanism whereby apoptosis of neutrophils can modify the inflammatory response is by modulating the pro- duction of proinflammatory cytokines ... apoptosis in the lungs of mice. They then showed that the mortality and the lung injury that follows ischemia/reperfusion decreased significantly when neutrophil apoptosi...

Ngày tải lên: 12/08/2014, 19:22

... probably related to a polymorphism of the platelet V 1 R [49]. V 1 Rs are found in the kidney, where they occur in high density on medullary interstitial cells, vasa recta, and epithelial cells of the ... neutral oxytocin evolution. Adv Exp Med Biol 1995, 395:615-627. 3. Oliver H, Schaefer EA: On the physiological action of extracts of the pituitary body and certain other glandu...

Ngày tải lên: 12/08/2014, 19:22