Báo cáo khoa học: " Role of iron in anaemic critically ill patients: it’s time to investigate" pps

... stimulatesCommentary Role of iron in anaemic critically ill patients: it’s time to investigate!Michael Piagnerelli1and Jean-Louis Vincent21Resident, Department of Intensive Care, Erasme ... common problem in critically ill patients admitted to intensive care units. Many factorscan be involved in its development, including rapid alterations in iron metabolism. Maintenance of iron homeostasis ... decrease in the iron level in blood.Proinflammatory cytokines such as tumour necrosis factor-α,IL-1β and IL-6 induce the transcription and the translation of ferritin; modulate the binding affinity...

Báo cáo khoa học: "Role of Verbs in Document Analysis" pot

... INTERPRETATION: posted earnings; 7. ANECDOTES; 8. OTHER: poems. The goal of our research is to identify the role of verbs, keeping in mind that event profile is but one of many factors in ... still convinced that our initial hypothesis on the role of verbs in determining event profile was worth pursuing. We believe that these results are a by-product of lexical ambiguity and of ... to the editor), the in- dicators do not appear to be directly applicable to a finer classification of news articles. News articles can be divided into several stan- Role of Verbs in Document...

Báo cáo khoa học: Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells docx

... bothSH2 domains of SHP-2 in mitogen-activated protein(MAP) kinase activation by the ErbB family of recep-tors. A speciﬁc role for SHP-2 in MAP, but not c-Junamino-terminal kinase activation. ... previousstudies showing that EGFR is initially concentrated in caveolae within lipid rafts, but rapidly moves out of this membrane domain in response to EGF [7]. Theinefﬁcient movement of ErbB2 out of these ... 3D), indicating that EGF is not determinant in deﬁning the retention of ErbB2 into the lipid rafts.The effect of [D]-PDMP treatment was partiallyabolished by addition of exogenous GM3 to ganglio-side-depleted...

Báo cáo khoa học: Role of Tyr84 in controlling the reactivity of Cys34 of human albumin potx

... School of Chemistry, University of Edinburgh, Edinburgh, UK2 Delta Biotechnology Ltd, Nottingham, UKHuman albumin (66.5 kDa), a single-chain of 585amino acids, is the most abundant protein in blood ... pairs. Interestingly however, the disulﬁdebonding pattern for the ﬁrst 50 residues in domain Idiffers from that of the other two domains. The ﬁrsttwo helices in the albumin sequence in domain ... reaction of albumin with cystine, leading to disulﬁde formation at Cys34, is of physiologicalimportance in blood. We monitored the reaction of wild-type rHA with a 2.5-fold molar excess of l-cystineby...

Báo cáo khoa học: Role of phosphorylation in p53 acetylation and PAb421 epitope recognition in baculoviral and mammalian expressed proteins pdf

... PAb240 from hybridoma cell lines detected thepresence of the epitope comprising amino acids 212–217 of the p53 protein and represents the amount of p53 proteinloaded in each lane [30]. Phosphorylation ... proteins mutated at speciﬁc phos-phorylation targets. Recombinant murine p53 proteins were expressed in insect cells (using the baculoviral expression vector system) and in a mam-malian in vitro ... fromhybridoma cell lines detected the presence of the epitopescomprising amino acids 371–382 and amino acids 370–378 of the p53 protein, respectively [31]. Peroxidase chemilumi-nescence blotting was performed...

báo cáo khoa học: "Role of TRIPTYCHON in trichome patterning in Arabidopsis" pptx

... [35]. In addition the MYBfactor binding to these MYB binding sites are in thesame clade in the phylogenetic tree as GL1 [36]. Wetherefore focused on these two putative binding sites. To determine ... and MYC binding sitesOur finding that the activators can activate the TRY pro-moter in transient expression assays together with thefinding that GL3 and GL1 bind to the TRY promoter in ChIP ... pro-tein functions could in principle be due to variousaspects including the protein stability, protein move-ment and their interaction with other proteins, in parti-cular the bHLH factors....

Báo cáo khoa học: "Blood glucose measurements in the critically ill: more than just a blood draw" doc

... problems of glucosemeasurements arising from matrix effects, interferences and theuse of different assays.Intensive insulin therapy in critically ill patients In the preceding issue of Critical ... measurement of blood glucose values with immediate feedback of results. In general, therefore, this is achieved by point -of- care testing, raisingthe question of the best way of monitoring blood ... 1 of 2(page number not for citation purposes)Available online http://ccforum.com/content/10/6/178AbstractA crucial determinant for the success of intensive insulin therapy in critically ill...

Báo cáo khoa học: "Kidney function assessment in the critically ill child: is it time to leave creatinine behind" pot

... analysis of the ability of cystatin C and β2microglobulin to reflect creatinine clearance in pediatric patients with AKI. The aim of this commentary is to reviewthe current state of AKI clinical ... andβ2microglobulin (β2M), to detect decreases in renal functionaccurately in 25 critically ill children [1].The authors conducted a careful study to obtain 24-hoururine collections of creatinine clearance ... criteria in a pediatric cohort of critically ill children: AKI by pediatricRIFLE during admission was an independent predictor of intensive care, hospital length of stay and an increased risk of death...

Tài liệu Báo cáo khoa học: Role of Kupffer cells in pathogenesis of sepsis-induced drug metabolizing dysfunction pptx

... shown that interactions betweenKCs and endotoxin comprise the initiating event lead-ing to hepatotoxicity in liver injury, including endotox-emia and ischemia ⁄ reperfusion injury [14]. In ourstudies, ... SJ(2008) Regulation of hepatic drug-metabolizing enzymegenes by Toll-like receptor 4 signaling is independent of Toll-interleukin 1 receptor domain-containing adaptorprotein. Drug Metab Dispos ... stimulation of these receptors activates in amma-tory responses characterized by the release of a widerange of proinﬂammatory cytokines, including IL-6 Sham GdCl3CLP GdCl3 + CLPHMGB1iNOSβ-actinFig....

Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx

... involvement of ADAM17, a metalloproteaseinvolved in catalyzing ectodomain shedding of RTKligands. In nonstimulated cells, ADAM17 is normally in complex with the integrin member a5b1and thusinactive. ... also unclear why the effector proteinCagA itself can bind to the extracellular domain of inte-grin b1because such high binding afﬁnity would beexpected to inhibit the injection process. However, ... basal membraneproteins to migrate apically. Transcytosis of integrinswould therefore enable H. pylori with the intriguingpossibility of targeting the integrin b1receptor at api-cal membranes...

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