... about
degrees of intervention may be clear but are often
disregarded by physicians given the uncertainty of predicting
critical care outcomes [1]. The aftermath of such immediate
Commentary
The role of teams ... teams in resolving moral distress in intensive care
unit decision-making
Mary van Soeren
1
and Adèle Miles
2
1
Assistant Professor, School of N...
... manifestation of the reper-
fusion injury. In order to determine the usefulness of ther-
apies against mast cells, it is important to know the degree
to which mast cells are involved in IR injury of other ... toluidine blue staining, mast cells were easily
distinguished from other cells, by their red or purple
stained cytoplasmic granules respectively. In general, they
were...
... by WSSV. The results suggested
that F
1
-ATP synthase beta subunit plays a role in the
WSSV infection.
Conclusions
F
1
F
0
-ATP synthase complexes play a central role in the
synthesis of ATP in ... as the receptor for the invertebrate
prokineticin, astakine, and it is located on the plasma
membrane of crayfish Hpt cells [26].It will be interesting
to further investig...
... early
onset of cdk2 kinase activity [28,30]. Tax also has the abil-
ity to increase cdk4 associated kinase activity in HTLV-1
infected cells by binding to p16/INK4A, resulting in the
inability of p16/INK4A ... other cyclin/cdk inhibitors in that
it has two cyclin binding sites, one localized within the N
terminus and the other at the C terminus [20]. p21/waf1
interacts wit...
... negligibly participates in the inhibition of papain
and most likely also of cathepsin L. The side chains of
Leu73 and Pro74 jointly contribute 45% of the total
unitary free energy of binding of cystatin ... cystatin A to cathepsin B,
demonstrating a major role of the second binding loop of
cystatin A in the inhibition of this enzyme. Pro74 may be
directly i...
... Tyr. These mutations may
in uence the shape and volume of the acyl binding pocket
and thereby alter the binding mode and affinity of the
enzyme for PAA and derivatives thereof, while maintaining
the ... the
nucleophilic serine, does in uence the rate of formation of
the acyl-enzyme, as judged by the effect of the mutations on
the activity, but does not in uen...
... Matthews, R.G. &
Penner-Hahn, J.E. (1998) Characterization of the zinc binding site
in methionine synthase enzymes of Escherichia coli – the role of
zinc in the methylation of homocysteine. ... the wild-type, the EXAFS analysis unambiguously
indicates that HS-CoM addition results in an increase in the
number of sulfur atoms in the first coordination sphe...
... Taiwan;
3
Department of Pharmacy and Pharmacology, The University of Bath, UK
Deacetoxycephalosporin C synthase (DAOCS) catalyses the
oxidative ring expansion of penicillin N, the committed step
in the biosynthesis ... these residues in
binding the carboxylate linked to the nucleus of penicillin N
(Arg160 and Arg162) and the carboxylate of the a-amino-
adipoyl si...
... to
microbes, which play a crucial role in the maturation of
the host immune system during the first years of life[4].
In addition to environmental factors, the intestinal flora
may be a contributor ... strong family history of eczema,
allergic rhinitis or asthma, and to their infants for the first
six months after delivery. The frequency of developing
atopic dermatit...
... Moreover, whereas the use of these drugs in
the management of acute pain is typically short term (a
few days to two weeks), their continuous usage in these
experiments was a departure from clinical practice.
Zhang ... homeostatic
mechanisms, their role in bone metabolism and repair
remains unclear.
Review of the evidence
To determine the role of COX-2 in bone repai...