Báo cáo y học: "Science review: Genetic variability in the systemic inflammatory response" pdf

... depending on the outcome of interest. Interleukin-1 αα and interleukin-1 ββ IL-1, a potent proinflammatory cytokine released by macrophages, also plays a key role in mediating endotoxin lethality ... proinflammatory cytokines, and anti-inflamma- tory cytokines (Table 1). The outcome of an inflammatory response is dictated by a variety of factors, including the pathogenicity and dura...

Ngày tải lên: 12/08/2014, 19:22

... understanding of the relationship between pH o and the synthesis and release of inflammatory molecules. Investigators continue to seek means to modulate the inflammatory response as primary therapy for ... conditions. These efforts have focused not only on reducing proinflammatory mediators in an effort to reduce tissue injury, but also on the converse – augmenting the inflam...

Ngày tải lên: 12/08/2014, 20:20

... Rodríguez-Gallego 1,3* Abstract Introduction: Genetic variability of the pulmonary surfactant proteins A and D may affect clearance of microorganisms and the extent of the inflammatory response. The genes of these collectins ... enhanced inflammatory pulmonary responses [35-37]. SP-A and SP-D play a dual role in the inflammatory response. They interact with pathogens via...

Ngày tải lên: 14/08/2014, 07:21

... 8-year retrospective study in which they investigated the changes in clinical practice of NIV in COPD patients. In that survey the failure rate with NIV was constant over time, regardless of the increasing ... COPD exacerbations to standard medical therapy alone or medical therapy combined with NIV. Intubation and mortality rates in the NIV group were lower than in the c...

Ngày tải lên: 12/08/2014, 20:20

... it maintains airway patency and prevents pulmonary infection. However, tracheal suctioning induces mucosal injury, exposing the basement membrane and thereby facilitating bacterial adhesion in ... articles. The following search terms were used: airway hygiene, oral hygiene, mucociliary clearance, tracheal suctioning, bronchoscopy, mucolytics, chest physiotherapy, kinetic therapy, contin...

Ngày tải lên: 13/08/2014, 08:21

... without the help of others. Over the last 200 years, the economies of Africa have grown by approximately 0.7% per year, while the US has grown by 1.7% per year, resulting in a 25-fold increase in ... the nearly 6 billion people in the world today, roughly 1 billion live in extreme poverty. They are nearly all inhabitants of ‘developing’ countries, predominantly in sub-Sa...

Ngày tải lên: 13/08/2014, 11:22

... resource use. In this article we review the most commonly used scoring systems in each of these three groups. We examine the history of the development of the initial major systems in each group, ... patients with a very short length of ICU stay, and so on). Second, the accuracy of any scoring system is highly dependent on the quality of the input. To be used correc...

Ngày tải lên: 13/08/2014, 20:21

... plumbagin. YgfZ and SodA independently required for resolving plumbagin toxicity Since both ygfZ and sodA were found critical for E. coli to resolve the plumbagin toxicity, we examined whether they ... li kely to combat plumbagin toxicity by detoxifying the superoxide. On t he other hand, in view of the fact that plumbagin is degraded by E. coli, it is then reasonable to hypothesize t...

Ngày tải lên: 10/08/2014, 05:21

... (pericytes, cardiomyocytes, smooth muscle cells, keratinocytes) and by vascular monocytes and endothelial cells upon induction by inflammatory cytokines or endotoxin [3]. TF is the high-affinity cellular ... coagulation pathways [29]. Taken together, these findings strongly suggest that the initiation phase of the coagulation pathways can sustain an inflammatory lethal response, ind...

Ngày tải lên: 12/08/2014, 19:21

... observed in septic shock. In part, they do so by triggering the release of many secondary cytokines, includ- ing IL-6, and numerous chemokines, which may further con- tribute to the septic syndrome. It ... occur in the setting of infection, and it is possible that the primary genetic lesions in autoimmunity involve components of the same system that induces cytokine produc...

Ngày tải lên: 12/08/2014, 19:21