Báo cáo y học: "Mechanisms of ventilator-induced lung injury: the clinician’s perspective" docx

... in the literature regarding the safety and efficacy of the Acute Respiratory Distress Syndrome (ARDS) Network study protocol in reducing ventilator-induced lung injury. The issues surrounding the ... hypercapnia not only may protect the lung but also may even have its own therapeutic benefit [5]. However, failure to increase the respiratory rate as dictated by the ARDS...

Ngày tải lên: 12/08/2014, 19:22

... downstream of phosphorylation cascade of PERK and eIF-2a.CHOPhasaroleinthe induction of cell death by promoting protein synthesis and oxidation in the stressed ER. It modulates the Bcl-2 family of proteins, ... normal cells offers an advantage for the agents that target the UPR to achieve the specificity in cancer therapy. The therapeu- tic potential of targeting the U...

Ngày tải lên: 10/08/2014, 21:23

... severity in the airways of asthmatic patients. 58 Moreover, neu- trophils and their products are strongly associ- ated with early pathogenesis of COPD. 59 Further analysis of the signalling pathways ... contents. In the case of exocytosis, this increases the total surface area of the cell and exposes the interior membrane surface of the gran- ule to the exterior. T...

Ngày tải lên: 08/08/2014, 21:20

... Furthermore, the relative contribution of these two pathways in the induction of oral tolerance to defined antigens remains to be determined. Concluding remarks The identification of the role of ... mice. Functionally, they inhibit collagen type II-specific T cell proliferation and pro-inflammatory Th1 cytokine production, and more importantly, induce the generation of col...

Ngày tải lên: 09/08/2014, 10:23

... leading to bony spurs, syndesmophytes, enthesophytes and eventually joint or spine ankylosis, are hallmark signs of these diseases. This process of ankylosis contributes significantly to the perma- nent ... mice to study molecular mechanisms of ankylosing enthesitis [19]. These immuno- logically normal mice develop oligoarthritis, especially in the toes of the hind limbs, from...

Ngày tải lên: 09/08/2014, 13:22

... pulmonary dis- ease (COPD) [1]. CS initiates the infiltration of innate and adaptive inflammatory cells into the airways and the lung parenchyma and further destroys the alveolar structure [2- 6]. The ... significantly prevented the lung inflammation induced by exposure to CS. CXCR3 may be a key factor in CS-induced pulmonary injury by regulating the recruitment of CD8+...

Ngày tải lên: 12/08/2014, 14:20

... subjects were kept unaware of the hypothesis of the study and the purposes of the vibration until after their final post vibration MVC. Hamstrings MVCs were included in this study to provide evidence ... than the algebraic sum of the individual inhibitory/disfacilitatory inputs [59]. In this way, even if prolonged vibration exactly mimicked the loss of Ia afferent...

Ngày tải lên: 12/08/2014, 18:20

... maneuvers by HFOV and PCV, but remained in the normal ranges in the present study; it is expected that these effects can easily corrected either by volume administration or by the adaptation of the ... acute respiratory distress syndrome. The findings of an HFOV initiation protocol by stepwise increases of CDP can therefore only be compared with the used lung recruitment s...

Ngày tải lên: 12/08/2014, 23:24

... High Wycombe, UK. The positions of the left ventricular catheter and pulmonary artery catheter were verified by typical waveforms. All intravascular catheters were zeroed to the atmosphere. The midpoint ... acute respiratory distress syndrome. The findings of an HFOV initiation protocol by stepwise increases of CDP can therefore only be compared with the used lung recruitm...

Ngày tải lên: 12/08/2014, 23:24

... Clinical School, Faculty of Medicine, University of Sydney, Sydney, NSW, Australia, 3 Centre for Immunology, St. Vincent's Hospital and University of NSW, Sydney, NSW, Australia, 4 Retroviral ... University of Sydney, Sydney, NSW, Australia, 5 National Serology Reference Laboratory, St Vincent's Institute, Melbourne, VIC, Australia, 6 Department of Microbiology and Im...

Ngày tải lên: 13/08/2014, 05:21