Báo cáo y học: "bench-to-bedside review: Endothelial cell dysfunction in severe sepsis: a role in organ dysfunction" pdf

... (0.05) Morphometric analysis evaluating the number of gaps per area along the sinusoidal endothelial lining, studied by SEM. Results are expressed as mean (standard deviation) and significance was determined ... days. Endothelial cells lining liver sinusoids are likely to be the first to sense changes in shear stress. Those cells are unique as they have no typical basal lamina. Moreove...

Ngày tải lên: 13/08/2014, 13:20

... synthase. Circulation 2000, 101:931-937. 85. Shindo T, Kurihara H, Maemura K, Kurihara Y, Kuwaki T, Izumida T, Minamino N, Ju KH, Morita H, Oh-hashi Y, Kumada M, Kangawa K, Nagai R, Yazaki Y: ... the principal activator of the extrinsic coagulation pathway, and as such is responsible for an intravascular procoagulant state. Taylor and coworkers concluded that sustained injury to the vascul...

Ngày tải lên: 12/08/2014, 19:22

... end of initial coronary angiography to 48 h of prophylactic IABP therapy (n = 23) or standard care (n = 22). The primary endpoint was IRA patency (defined as Thrombolysis in Myocardial Infarction ... not broad since data for this economic analysis was only based on inhospital billings. It may be argued that from an economic standpoint, the advantages or disadvantages of IABP ther- apy may b...

Ngày tải lên: 12/08/2014, 18:20

... After adjustment for age and clinical factors and stratification by site and initial modality of RRT in a multi- variate analysis, the relative risk of death associated with dialysis initiation ... outcomes in patients with post-traumatic AKI by stratifying 100 consecutive patients based on the BUN at initiation of treatment. ‘Early’ and ‘late’ initiation of therapy were defined by stra...

Ngày tải lên: 13/08/2014, 08:20

... Matsuura T, Kawada M, Hasumura S, Nagamori S, Obata T, Yamaguchi M, Hataba Y, Tanaka H, Shimizu H, Unemura Y, Nonaka K, Iwaki T, Kojima S, Aizaki H, Mizutani S and Ikenaga H High den- sity culture ... measuring the radioactivity in the pellet and supernatant that was obtained after cen- trifugation of the media. Cell- associated ligand was quan- tified by measuring the amount of radioact...

Ngày tải lên: 13/08/2014, 13:20

... nuclear extracts were incubated with avidin–agarose beads (Sigma) at 4 °C for 30 min to eliminate materials in the extracts that bind nonspecifically to the beads. After removing the beads by filtration, ... suggest that the Ku proteins that bind specifically to MREa play an important role as a basal regulator of WD gene transcrip- tion. MATERIALS AND METHODS Cell culture The human hepat...

Ngày tải lên: 17/03/2014, 23:20

... data again show that a t- NRTI regimen that contains a thymidine analog with 3TC and ABC has virologic efficacy comparable to that of a PI- based regimen, but inferior to that of an EFV-based ... al.: Abacavir-lamivudine- zidovudine vs indinavir-lamivudine-zidovudine in antiretro- viral-naive HIV-infected adults: A randomized equivalence trial. JAMA 2001, 285:1155-1163. Abstract 10....

Ngày tải lên: 20/06/2014, 08:20

... os- ingDIC,wechosetomeasureD-Dimerasamarkerof coagulation in this study as it is widely available, a cor- relate to the pro-inflammatory cytokine levels, and a valuable screening marker for organ failure and mortal- ity ... caspases can activate caspase-3 in the common pathway resulting in final cell death. Caspases are pro-apoptotic proenzymes that inactivate protective protein...

Ngày tải lên: 11/08/2014, 08:22

... the in ammatory actions of Ang II. ACE and ACE2 are both chloride-activated metallo- peptidases that are predominantly associated with the cell membrane and are widely distributed in various ... the renin–angiotensin system – and speci cally the angiotensin-converting enzyme (ACE)– angiotensin (Ang) II–AT 1 receptor axis – may play a prominent role to promote in ammation and ...

Ngày tải lên: 12/08/2014, 14:22

... hemorrhage and coagulopathy in critical care patients carries significant morbidity and mortality, with increased incidence of respiratory failure and renal failure as well as multiple organ dysfunction. ... upper gastrointestinal bleeding. Despite adequate and aggressive resuscitation and medical management, he continues to hemorrhage. Administration of FVIIa is certainly warranted in...

Ngày tải lên: 12/08/2014, 23:24