... the translocated loop playsa key role in defining the hydrophobicity of the A2 signalpeptide, which is of necessity low in order to facilitate the movements that allow the final cleavage on the ... to a product of similar mobility to the mature protein, indicating that the loop region is exposed to the lumen. The PsbX/NN mutantbehaves similarly; most of the protein is of mature-size by the ... efficiencyis restored to an extent, but not completely, by the highlyhydrophilic Asn, implying that this domain is required to behydrophilic, but preferably negatively charged, in order to present...