Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside" pot

... basic research. The potential key role of proteins that were originally believed to be exclusively involved in coagulation in the inflammatory response provides an exciting potential mechanism(s) ... augmenting or inhibiting the contribution of the clotting cascade components to inflammation would be required for determining the selection and dosing of potential new therapies. Alter...

Ngày tải lên: 12/08/2014, 19:21

... 189] PABP1 Poly(A) tail binding protein involved in RNA translation and RNA stability Binds HIV-1 instability (INS) RNA sequences ?[190] PSF Pre-mRNA splicing factor associated to polypyrimidine tract ... significantly from consensus. In contrast, the polypyrimidine tracts are interrupted by purines, which may reduce splice site usage by decreasing binding of the splicing factor...

Ngày tải lên: 13/08/2014, 09:21

... the effect of inflammatory mediators on the brain. Investigations addressing SAD will remain difficult due to the problem of correctly identifying and quantifying this entity. The value of monitoring cerebral ... Therefore, one could speculate that, in analogy to traumatic brain injury, severe brain dysfunction is necessary to disturb CO 2 reactivity. The action of inflammatory mediat...

Ngày tải lên: 13/08/2014, 08:21

... may simply be an indicator of a high degree of the systemic inflammatory response (that is, an indicator of more severe disease) [39]. Second, some of our patients had hydrocortisone therapy ... most probably multifactorial in origin, remain obscure. Important precipitating factors possibly include reduced cerebral blood flow (CBF) and oxygen extrac- APACHE II = Acute Physiology and Chronic...

Ngày tải lên: 13/08/2014, 11:22

... myocardial infarction were reduced. Hypotension was very instrumental in causing the adverse events. Interestingly, sepsis and infection were also clearly more common on metoprolol. Commentary Myocardial ... when using β-blockers in acute settings of hemodynamic com- promise. The COMMIT trial in acute myocardial infarction showed that metoprolol’s benefit in reducing reinfarction and...

Ngày tải lên: 13/08/2014, 11:22

... Consistently, disruption of TNFα signaling – either by removing TNFα or TNF receptor 1 – prevents this hepatocyte apoptosis in rela –/– mice, allowing embryonic development to birth. In agreement ... these studies, inhibition of NF-κB after partial hepatectomy results in massive hepatocyte apoptosis and impairs liver function. Conversely, NF-κB activation in the liver prevents hepat...

Ngày tải lên: 13/08/2014, 16:20

... and actually exacerbate liver injury [9]. In addition to apoptosis, certain caspases, such as caspase-1, are involved in cytokine maturation by proteolytically proces- sing the inactive precursors of interleukin ... interleukin (IL)-1β and IL-18, also known as interferon-gamma (IFN-γ)-inducing factor, to the active cytokines. There are several independent obser- vations that the gener...

Ngày tải lên: 13/08/2014, 18:22

... brain and regulates brain capillary blood fl ow [1]. In sepsis, cerebral endothelial cells are activated by lipopoly- saccharide (LPS) and pro -in ammatory cytokines, including bradykinin, ... brain function in sepsis. Sepsis and the brain In sepsis, the brain may be aff ected by many systemic disturbances, such as hypotension, hypoxemia, hyper- glycemia, hypoglycemia, and organ dysfun...

Ngày tải lên: 13/08/2014, 20:21

... erences in terms of the number of circulating NK cells, CD4 + T lymphocytes, CD8 + T lymphocytes, and B lymphocytes was limited to community-acquired pneu- monia and intra-abdominal infection. ... F, Schywalsky M, Schuttler J: Coincidence of pro- and anti -in ammatory responses in the early phase of severe sepsis: longitudinal study of mononuclear histocompatibility leukocyte a...

Ngày tải lên: 13/08/2014, 20:22

... thus may be less likely to commit sui- cide. Increased insight may parallel increased suicidality, but this is not per se a reason to try to decrease insight in patients with schizophrenia. In fact, ... Depres- sive symptoms have already been addressed, but they frequently coexist with anxiety symptoms [90,91]. Anxiety contributes to suicidality in post-psychotic depression [92]...

Ngày tải lên: 08/08/2014, 21:20