Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside" pot
Báo cáo y học: "Coagulation cascade in sepsis: getting from bench to bedside" pot
... basic research. The
potential key role of proteins that were originally believed to
be exclusively involved in coagulation in the inflammatory
response provides an exciting potential mechanism(s) ... augmenting or inhibiting the contribution of the
clotting cascade components to inflammation would be
required for determining the selection and dosing of potential
new therapies.
Alter...
Báo cáo y học: " The retrovirus RNA trafficking granule: from birth to maturity" pot
... 189]
PABP1 Poly(A) tail binding protein
involved in RNA translation and
RNA stability
Binds HIV-1 instability (INS)
RNA sequences
?[190]
PSF Pre-mRNA splicing factor
associated to polypyrimidine
tract ... significantly from consensus. In
contrast, the polypyrimidine tracts are interrupted by
purines, which may reduce splice site usage by decreasing
binding of the splicing factor...
Báo cáo y học: "Brain dysfunction in sepsis: what can we learn from cerebral perfusion studies" pdf
... the
effect of inflammatory mediators on the brain.
Investigations addressing SAD will remain difficult due to the
problem of correctly identifying and quantifying this entity.
The value of monitoring cerebral ... Therefore, one could speculate that, in analogy to
traumatic brain injury, severe brain dysfunction is necessary
to disturb CO
2
reactivity. The action of inflammatory
mediat...
Báo cáo y học: "Cerebral perfusion in sepsis-associated delirium" pdf
... may simply be an indicator
of a high degree of the systemic inflammatory response (that
is, an indicator of more severe disease) [39]. Second, some of
our patients had hydrocortisone therapy ... most probably multifactorial in origin,
remain obscure. Important precipitating factors possibly
include reduced cerebral blood flow (CBF) and oxygen extrac-
APACHE II = Acute Physiology and Chronic...
Báo cáo y học: "Myocardial protection in sepsis" potx
... myocardial infarction were
reduced. Hypotension was very instrumental in causing the
adverse events. Interestingly, sepsis and infection were also
clearly more common on metoprolol.
Commentary
Myocardial ... when
using β-blockers in acute settings of hemodynamic com-
promise. The COMMIT trial in acute myocardial infarction
showed that metoprolol’s benefit in reducing reinfarction and...
Báo cáo y học: "Neuroimmune perspectives in sepsis" pps
... Consistently, disruption of TNFα
signaling – either by removing TNFα or TNF receptor 1 –
prevents this hepatocyte apoptosis in rela
–/–
mice, allowing
embryonic development to birth. In agreement ... these
studies, inhibition of NF-κB after partial hepatectomy results
in massive hepatocyte apoptosis and impairs liver function.
Conversely, NF-κB activation in the liver prevents hepat...
Báo cáo y học: "Cell death in sepsis: a matter of how, when, and where" potx
... and
actually exacerbate liver injury [9].
In addition to apoptosis, certain caspases, such as caspase-1,
are involved in cytokine maturation by proteolytically proces-
sing the inactive precursors of interleukin ... interleukin (IL)-1β and IL-18,
also known as interferon-gamma (IFN-γ)-inducing factor, to
the active cytokines. There are several independent obser-
vations that the gener...
Báo cáo y học: "Cerebral perfusion in sepsis" pot
... brain and regulates brain capillary blood fl ow [1]. In
sepsis, cerebral endothelial cells are activated by lipopoly-
saccharide (LPS) and pro -in ammatory cytokines,
including bradykinin, ... brain function in sepsis.
Sepsis and the brain
In sepsis, the brain may be aff ected by many systemic
disturbances, such as hypotension, hypoxemia, hyper-
glycemia, hypoglycemia, and organ dysfun...
Báo cáo y học: " Immune status in sepsis: the bug, the site of infection and the severity can make the difference" docx
... erences in terms of the number of circulating NK
cells, CD4
+
T lymphocytes, CD8
+
T lymphocytes, and B
lymphocytes was limited to community-acquired pneu-
monia and intra-abdominal infection. ... F, Schywalsky M,
Schuttler J: Coincidence of pro- and anti -in ammatory responses in the
early phase of severe sepsis: longitudinal study of mononuclear
histocompatibility leukocyte a...
Báo cáo y học: "Suicide risk in schizophrenia: learning from the past to change the future" pot
... thus may be less likely to commit sui-
cide.
Increased insight may parallel increased suicidality, but
this is not per se a reason to try to decrease insight in
patients with schizophrenia. In fact, ... Depres-
sive symptoms have already been addressed, but they
frequently coexist with anxiety symptoms [90,91]. Anxiety
contributes to suicidality in post-psychotic depression
[92]...