Báo cáo y học: "Science review: Redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: κ role for nuclear factor-κ" pdf

... to increasing intracellular stores of GSSG, a potent inhibitor of NF-κB transcription factor DNA binding. The pathway leading to the formation of GSH by the action of γ-glutamylcysteine synthetase ... lungs before any increase in proinflammatory cytokine protein occurs, and they further suggest that NF-κB activation may represent an initial event in the proinflammatory...

Ngày tải lên: 12/08/2014, 19:21

... and inflammatory stimuli, and hypoxemia and the crucial role of hypoxia-inducible factor in mediating lung injury. Changes in the pattern of gene expression through regulatory transcription factors ... lipopolysaccharide- induced proinflammatory cytokine biosynthesis in an I κ B- αα /NF- κ B-dependent mechanism. Evidence for the amplification of an antiin...

Ngày tải lên: 12/08/2014, 19:21

... adipocytic/fat-storing mesenchymal cells and loss of thymocytes with advancing age lead to a novel con- ceptual point of view concerning the understanding of the process of thymic physiology in ... observed in thymocytes and in mul- tilocular cells in the septa and inside the thymic pa- renchyma. These data reinforced the hypothesis that adipocytic mesenchym...

Ngày tải lên: 08/08/2014, 18:20

... V 3 pituitary and oxytocin receptors, and the P 2 class of purinoreceptors. Knowledge of the function and distribution of vasopressin receptors is key to understanding the seemingly contradictory actions ... G- proteins of the G q/11 family. The α-subunits regulate the activ- ity of the β-isoforms of phospholipase C [29]. A variety of signaling pathways is a...

Ngày tải lên: 12/08/2014, 19:22

... vasopressin interaction in these pathways. We discuss the seemingly con- tradictory studies and some new information regarding the actions of vasopressin on the heart. Finally, we summarize the clinical ... vasodilation of others. Vasopressin and the heart The actions of vasopressin on the heart are complex and the studies are seemingly contradictory. Depending o...

Ngày tải lên: 12/08/2014, 19:22

... Sweden) and the bands were revealed by silver staining. The gels were scanned and the intensity of each band on the gel was analyzed with IPLab Gel soft- ware (BioSystematica, Plymouth, UK). The ... for assigning the patients to various categories, we set the intensity of the 676-bp band of the molecular mass marker on each gel as the arbitrary cutoff point (Fi...

Ngày tải lên: 09/08/2014, 01:23

... biology studies. LJC conceived the study. LJC, SS and AL initiated the design of the study and QY performed the statistical anal- ysis. LJC and QY participated in the final figure prepara- tion and ... silenced the expression of NFκB in TE26 using lentiviral siRNA targeting the p50 of the NFκB dimer and compared the readthrough efficiency of SIN LTR, WT...

Ngày tải lên: 13/08/2014, 09:20

... secondarily in uences IAP/IAH is likely to greatly in uence respiratory mechanics and outcomes. Further study of the role of IAP/IAH in the physiology and outcomes of PV in hypoxemic respiratory failure ... IAH and intra-abdominal volume or thus the compliance of the abdominal wall, and of the potential di erence in the abdominal in uences between...

Ngày tải lên: 13/08/2014, 21:20

... of catecholamine dysfunction and refractory hypotension [5]. Downregulation of catecholamine receptors occurs with prolonged use of exogenous catecholamines and this may be reversed with administration ... 60-year-old man has been in your intensive care unit with septic shock for 5 days and he has required a norepinephrine infusion for the entire time. He had multisystem o...

Ngày tải lên: 12/08/2014, 18:21

... Cohn 4 1 Professor and Chief of Intensive Care and Accident Department, University Hospital Maastricht, The Netherlands 2 Trauma Surgeon and Intensivist, University Hospital Maastricht, The Netherlands 3 Fellow ... sepsis and mortality. They included a study by Luiten and colleagues [8], which used selective decontamination of the digestive tract. Selective decontamination...

Ngày tải lên: 12/08/2014, 19:22