Báo cáo y học: "Science review: Mechanisms of ventilator-induced injury" pps

... lung Review Science review: Mechanisms of ventilator-induced injury James A Frank 1 and Michael A Matthay 2 1 Assistent Professor of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, ... potentially magnifying the severity of lung injury. Despite the demonstrated benefits of tidal volume reduction, the mechanisms of the protective effe...

Ngày tải lên: 12/08/2014, 19:21

... (pericytes, cardiomyocytes, smooth muscle cells, keratinocytes) and by vascular monocytes and endothelial cells upon induction by inflammatory cytokines or endotoxin [3]. TF is the high-affinity cellular ... strategies in sepsis therapy. Keywords inflammatory balance, protein C, sepsis, tissue factor 126 PAR2 by APC in heterologous expression systems [21]. Physiologically relevant primary end...

Ngày tải lên: 12/08/2014, 19:21

... inflam- matory response. Alternatively, a systemic inflammatory response may be triggered by trauma, by pancreatitis, by ischemia reperfusion injury, by burns, and by surgery. Once a systemic inflammatory ... manner. Summary Many experimental studies of the physiopathology of alveolar edema in ALI indicate that cellular mechanisms are important in the resolution of ALI. Several of t...

Ngày tải lên: 12/08/2014, 20:20

... microsomal 6β-hydroxylase and the cytosolic 4-ene-reductase, members of the cytochrome 3A subfamily – may be inhibited by a number of drugs (Table 1), including ketoconazole and cyclosporine [40], ... suppression of CRH and ACTH synthesis, and result in slow onset secondary adrenal insufficiency that may outlast exposure to this treatment [12]. The duration of suppression of the hyp...

Ngày tải lên: 12/08/2014, 20:20

... that TNF might act as one of a collec- tion of endogenous mediators of endotoxicity. TNF was known to synergize with IFN-γ in many of its effects (i.e. in its cytolytic effect on certain cultured ... active phagocytes, and are quite capable of Review Science review: Key inflammatory and stress pathways in critical illness – the central role of the Toll-like receptors Bruce Beutl...

Ngày tải lên: 12/08/2014, 19:21

... hours of hyperoxia (relatively early events). Following 24 hours of hyperoxia, however, NF-κB activation and increased levels of TNF-α mRNA were present in pulmonary lymphocytes. By 48 hours of hyperoxia, the ... formation of GSH by the action of γ-glutamylcysteine synthetase (GCS) is blocked by L-buthionine-(S,R)-sulfoximine (BSO), inducing an irreversible inhibition of NF-κB...

Ngày tải lên: 12/08/2014, 19:21

... hypoxia and by cytokines. To identify the cellular mechanisms in control of tubular VEGF production, the effects of hypoxia and IL-1β on VEGF mRNA levels, on VEGF secretion and on activity of ... irreversible inhibitor of γγ -glutamylcysteine synthetase, augments LPS- mediated pro-inflammatory cytokine biosynthesis: evidence for the implication of an I κκ B- αα /NF- κκ B insensit...

Ngày tải lên: 12/08/2014, 19:21

... contraction, by irregularity of ventricular contraction [43], by inadequate filling time for the left ventricle due to tachycardia, and by tachycardiomyopathy [8,44]. Tachycardiomyopathy can occur ... Bolcal C, Gunay C, Demirkilic U, Tatar H: Supraventricular tachyarrythmia prophylaxis after coronary artery surgery in chronic obstructive pulmonary disease patients (early amiodarone prophyla...

Ngày tải lên: 25/10/2012, 10:35

... design of the study, carried out analyses and drafted the manuscript. AF analyzed gene structures of selected examples. AB conceived of the study and participated in design of the study and writing ... drivers of the evolution of organismal complexity [3]. This is supported by a recent study that experimentally showed that recombination of domains encoded by genes that belong to...

Ngày tải lên: 09/08/2014, 20:22

... in primary OA synovial cells as well as in model cells, which suggested anti-inflammatory mechanisms of the PAR2-IP. Trypsin is well recognized as an activator of PAR2. Importantly, trypsin was ... demonstrated inhibitory effect of PAR2-IP on trypsin-induced activation of NF- B, and down-regula- tion of inflammatory COX-2 expression in human syno- viosarcoma and primary OA synovi...

Ngày tải lên: 10/08/2014, 05:21