Báo cáo y học: "Hypertonic saline resuscitation in sepsis" pps

... ml/kg hypertonic saline in hydroxyethyl starch. Following administration there was a small effect on oxygenation by increasing cardiac output and oxygen delivery. There was no control group in this study for ... Recently, Shi and coworkers [11] found resuscitation with hypertonic saline to Commentary Hypertonic saline resuscitation in sepsis Charles E Wade Adjunct Professor, D...

Ngày tải lên: 12/08/2014, 19:21

... the hypertonic saline exposure, while the CFTR KO mice did not exhibit increases in SCN. This suggests that while hypertonic saline may afford some protection by increasing GSH in CFTR KO airways, ... can protect airway epithelium from HOCl mediated injury. These findings indicate another therapeutic benefit of hypertonic saline, apart from hydration of the airways, is through increa...

Ngày tải lên: 12/08/2014, 11:22

Ngày tải lên: 13/08/2014, 01:20

... insertions directly into the Myc locus, almost all T lymphomas overexpress Myc as compared to normal splenocytes and thymocytes, whether there are insertions into the Myc locus, Pvt1 locus, or into an ... the nearby Myc locus – Pvt1 and the microRNAs encoded by it are as important as Myc in T lymphomagenesis, and, presumably, in T cell activation. An analysis of the co-mutations in the...

Ngày tải lên: 13/08/2014, 06:20

... is on the major non-crosslinking AGE N ε -carboxymethyllysine. Kneyber and colleagues focused on sepsis-induced cardiac dysfunction and investigated whether myocardial inflammation is associated ... ill patients are a driving force of the disease. Advanced glycation endproducts The advanced glycation endproduct (AGE) N ε -carboxy- methyllysine (CML), as recently investigated by Kneyber and co...

Ngày tải lên: 13/08/2014, 16:21

... accelerantes (thereby reducing or maintaining cardiac output, respec- tively), and the continuous, proven reduction of sympathetic activity - including or excluding the adrenal glands - during the different ... NO. This study shows the importance of distinguishing between different phases of disease, especially during early (hyperdynamic) and late (hypodynamic) sepsis. One has to keep in mi...

Ngày tải lên: 13/08/2014, 18:22

... the increase in monocyte apoptosis, and the lower release of pro-inflammatory cytokines, namely tumor necrosis factor-alpha and interleukin-6, from monocytes after stimula- tion with lipopolysaccharide ... stimulation by endotoxin [4]. Endotoxin tolerance has been considered a paradigm of immunoparalysis [5], which is present not only in sepsis but also in systemic inflammatory response...

Ngày tải lên: 13/08/2014, 20:21

... D, Ghofrani HA, Schermuly RT, Grimminger F, Kaps M: Microcirculatory dsyfunction in the brain precedes changes in evoked potentials in edotoxin-induced sepsis syndrome in rats. Cerebrovasc Dis ... shown that microcirculatory dysfunction in the brain precedes changes in evoked potentials [21]. Taking the absolute blood flow velocities and pulsatility indices in the present stud...

Ngày tải lên: 13/08/2014, 20:21

... serine/threonine protein kinase (AKT) were determined by real-time quantitative PCR. (a) In the case of TNFα, induction levels were also analysed when monocytes were challenged with lipopolysaccharide ... aspartate aminotransferase and/or alanine aminotransferase level >100 IU/l; prothrombin time <60%, total bilirubin level >60 μmol/l), renal insu ciency (plasma creatinine leve...

Ngày tải lên: 13/08/2014, 21:21

... gain further insight into the role of nucleosomes in gene regulation, we systematically evaluated promoter nucleo- some occupancy in yeast by immunoprecipitating nucleo- somal DNA and quantifying ... Rap1 in a global ChIP study [1]. (b) Nucleosome depletion in the vicinity of Rap1-binding sites in ribosomal gene promoters evaluated by ChIP. Fold-enrichment was determined by real-ti...

Ngày tải lên: 14/08/2014, 14:21