... association of MMP-1 to mito- chondria and nuclei have implications for the control of cell growth, and may contribute to the well-known association of this enzyme with tumor cell survival and spreading ... to health and disease. MMP-2 degradation of TnI is associated with diminished contractive function of the heart [11], MMP-9 degradation of aB-crystallin with mult...
Ngày tải lên: 15/03/2014, 00:20
... frontoeth- moidectomy, and in selected cases, endoscopic excision, are discussed [8]. A detailed assessment of the margins of the tumor and definition of its relation with the surrounding structures ... the extension of ethmoid osteomas [10]. In our case, careful analysis of CT scan in the axial and coronal view determined the size of the tumor and differentiated osteoma...
Ngày tải lên: 09/08/2014, 07:21
báo cáo khoa học: "Immobilization of different biomolecules by atomic force microscopy" pptx
... experiments and designed most of them. RH and FB conceived of the study and participated in its design and coordination. The authors participated in the evaluation and interpretation of the experiments. MB ... concentration of 0.5 mM. Incu- bation time for binding was 5 minutes and was stopped by washing with 1× PBS-buffer and ultrapure water. Oli- gonucleotides were t...
Ngày tải lên: 11/08/2014, 00:22
Tài liệu Báo cáo khoa học: Basis of recognition between the NarJ chaperone and the N-terminus of the NarG subunit from Escherichia coli nitrate reductase pdf
... biphasic, with the best fit obtained with a two binding site model, comprising a first site with binding stoichiome- try (n) of 0.3 ± 0.2 and a binding constant (K d )of 3.4 ± 4 · 10 )9 m and a second with ... 7, k off varied by nearly a factor of 10 between the two subpop- ulations, i.e. k off = 3.2 ± 1 s )2 for the minor species of high affinity and k off = 1.9 ± 1 s )1 f...
Ngày tải lên: 16/02/2014, 14:20
Tài liệu Báo cáo khoa học: Roles of heat shock factors in gametogenesis and development pptx
... over-expres- sion of Hsp60 and Hsp70 and exhibit abnormal mor- phology in correlation with increased proliferation, premature differentiation and elongation, inhibition of denucleation and of loss of organelles ... mechanisms for the lack of HSF2. In line with this hypothesis, double disruption of Hsf1 and Hsf2 is associated with sterility and complete arrest of...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Effect of siRNA terminal mismatches on TRBP and Dicer binding and silencing efficacy pdf
... target, loading of the appropriate guide strand into the RISC is critical. Improved understand- ing of the interactions of siRNAs with TRBP and Dicer will enable improved design of siRNA therapeutics. In ... behavior of this sequence could be due to enhanced interactions with Dicer and a reduced need to interact with TRBP, relative to the other sequences. Effect of guide...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: Structure of RNase Sa2 complexes with mononucleotides – new aspects of catalytic reaction and substrate recognition pptx
... positions of the ribose and base of the second nucleotide. In all cases, the base of the second nucleotide interacted with the Asp66–Thr69 loop and with His86 (Fig. 4B). The majority of the five ... complex, O2¢ and O3¢ form hydrogen bonds with OE1 of Glu56 and NE2 of His86, respectively. Arg67 and Arg71 interact with the oxygens of the phosphate group, and si...
Ngày tải lên: 18/02/2014, 11:20
Tài liệu Báo cáo khoa học: Development of a new method for isolation and long-term culture of organ-specific blood vascular and lymphatic endothelial cells of the mouse pdf
... concentra- tion of G418 (Invitrogen) of 400 lgÆmL )1 . G418-resistant colonies were picked and expanded for PCR genotyping and the formation of embryoid bodies. One ESC clone (T26) out of 48 G418-resistant ... Yoshida and Hirotake Ichise Laboratory of Gene Expression and Regulation, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Japa...
Ngày tải lên: 18/02/2014, 17:20
Tài liệu Báo cáo khoa học: Characterization of chitinase-like proteins (Cg-Clp1 and Cg-Clp2) involved in immune defence of the mollusc Crassostrea gigas docx
... sequence of about 90 amino acids of unknown function. The high degree of identity of the Cg-Clp1 and Cg-Clp2 Glyco_18 domains (84% iden- tity) argues for a conservation of the tertiary structure and ... edge and post- spawning gonads. Metamorphosis represents the ulti- mate stage of oyster development, and is characterized by the degeneration of larval tissues, such as t...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane pptx
... interfered with Alr1p function in Mg 2+ uptake. Distant relatives of Alr1p and Alr2p, the bacterial Fig. 2. Alignment of transmembrane parts of CorA-related proteins and mutational alterations Alr1p, and ... concentration of JS74A cells transformed with YCpALR1-myc and YEp351-HA (lane 1), YCpALR1-myc and YEpALR2-HA (lane 2), and YCp211-myc and YEpALR2-HA (lane 3). To...
Ngày tải lên: 19/02/2014, 06:20