Báo cáo y học: " Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension" ppt

... poly A binding proteins, and polypyrimidine tract binding protein) were predominantly regulated. FK506 binding protein 1a is well known to be involved in cell cycle regulation [32], but also in ... in pulmonary hypertension and vascular remodelling. For specific investigation of the vascular compartment, laser-microdissection of intrapulmonary arteries was combined with array...

Ngày tải lên: 12/08/2014, 18:22

... profi ling studies of rodents and canines, the study by Minogue and colleagues [1] indicated that cells present in the nucleus pulposus of adult bovine as well as human discs express brachyury ... substantially over lapping gene expression profi les, Abstract This editorial addresses the debate concerning the origin of adult nucleus pulposus cells in the light of pro ling s...

Ngày tải lên: 12/08/2014, 12:20

... quantita- tion of microgram quantities of protein utilizing the princi- ple of protein-dye binding. Anal Biochem 1976, 72:248-254. 25. Heukeshoven J, Dernick R: Improved silver staining procedure for ... proteins in pulmonary alveolar proteinosis in adults. Eur Respir J 2004, 24:426-435. 31. Vorbroker DK, Profitt SA, Nogee LM, Whitsett JA: Aberrant processing of surfactant prote...

Ngày tải lên: 12/08/2014, 18:21

... within 30 min and 45 min, respectively, of dosing with hydroxybupropion HCl 75 mg/kg. In addition, clin- ical signs, including ataxic gait, catatonia, changes in activ- ity, and changes in respiration ... liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice, namely erythrohydrobu...

Ngày tải lên: 08/08/2014, 23:21

... have anti-inflammatory proper- ties depending on the timing of TNFα expression in a murine model of autoimmune diabetes [9]. One possibility to consider is that TNFα acts on cells of the joint (for ... disease severity [5]. In another study, EAE failed to resolve in TNFα -/- or TNFR -/- mice, suggesting that TNFα plays an important role in resolution of inflammation [6]. In...

Ngày tải lên: 09/08/2014, 10:23

... based upon flow-cytometry data indicating increased rate of apoptosis of subpopulations of leukocytes involved in autoinflammation and recur- rent episodes of fever in FMF [7]. In addition, our ... since it preferentially binds PS with high affinity and inhi- bits apoptotic cell uptake by phagocytes [12,13]. ANX-V is produced by a variety of cells and is an in vivo marker o...

Ngày tải lên: 11/08/2014, 03:20

... only by dyspnoae, but also by RV dysfunction leading to BNP release. In hemodynamically stable patients, RV dysfunc- tion as observed by echocardiography has been shown to be able to identify ... PE. Table 1 Characteristics of included studies Reference Study design Patients, number Hemodynamic instability (number) Timing of BNP sampling Thrombolysis, number Age, years Male, percen...

Ngày tải lên: 13/08/2014, 11:22

... grouped into trafficking related clusters such as integrins, Mmps, chemokine and chemokine receptors, and interleukins and interleukin receptors. Integrins are key mediators of cell-cell interactions, ... 1 Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Giessen Lung Center, Klinikstr. 36, 35392 Giessen, Germany and 2 Institute for...

Ngày tải lên: 12/08/2014, 14:20

... Scott KF, Weininger L, Mackay CR, Rolph MS: Over- lapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines inter- leukin-1 beta and ... hetero- geneity within RA can already be observed in the early phase of RA. In this study, gene expression profiles were analyzed from synovial lining tissues from 12 patients with early...

Ngày tải lên: 09/08/2014, 01:22

... are not involved in the direct digestion of hyaluronan in joint fluids, because a neutral pH is maintained in synovial fluids, and so hyaluro- nidase-1 may function only within lysosomes. Hyaluronidase-2 ... healthy control donors. The message expression of hyaluronan synthase-1 and -2 in the synovium of both types of arthritis was significantly less than in the control sy...

Ngày tải lên: 09/08/2014, 01:24