Báo cáo y học: "A role for MCP-1/CCR2 in interstitial lung disease in children" pps

... the indicated time points, cells were washed in PBS and fixed by adding cold methanol-acetone (1:1 volume) at room temperature for 2 min. The slides were incu- bated with the primary antibody in ... rotein can be compensated for by other DSB repair systems or pro- teins. To test this hypothesis, we have induced a DSB repair deficiency in HeLa cells by treatment with an established A...

Ngày tải lên: 12/08/2014, 01:21

... and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis. J Clin Invest 1996, 97:2011-2019. 7. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, Lopez-Otin C, ... synthesis, but type II collagen synthesis is increased during OA as discussed above.  is discrepancy points to alternative players that are involved in OA. IL-1 might play a role in the...

Ngày tải lên: 12/08/2014, 11:22

... with interstitial lung disease (ILD) related to ILD disease severity. Percentages of CCR2 + CD4 + T cells were analyzed in BALF by flow cytometry. ILD disease sever- ity was scored according ... Corresponding author ChemokinesMCP-1CCR2Bronchoalveolar LavageChildrenInterstitial Lung Diseases Abstract Background: Interstitial lung diseases (ILD) are chronic inflammatory di...

Ngày tải lên: 12/08/2014, 18:22

Ngày tải lên: 13/08/2014, 01:20

... antibiotics, prophylactic antibiotics decreased the rate of pancreatic superinfection. This has been studied before, and similar findings were reported by Cinar and colleagues [4]. But in a study by Schwarz ... prophylactic and early therapeutic administration of both meropenem and ciprofloxacin in an animal model. How to translate these findings in clinical practice Although this exper...

Ngày tải lên: 13/08/2014, 11:23

... but a study published recently in Nature by Colaluca et al. [10] provides an extremely interesting alternative by describing a role for Numb in the regulation of p53 activity [10]. Previous ... complex than initially thought. The well characterized binding between the amino termini of the two proteins causes a conformational change, which allows binding between the DNA-binding domain...

Ngày tải lên: 14/08/2014, 08:21

... sections for each lung) onto ami- noalkylsilane-coated slides (SIGMA) followed by air-dry- ing for 2 hrs. Samples were fixed in 4% paraformaldehyde in PBS for 20 min, protein hydrolyzed in 20 µg/ml ... (calprotectin), but not S100A9 alone, as having a possible role in progression of the inflammatory lung phenotype in CF mice. Finally, since both the B6-CF and Bc-CF mice w...

Ngày tải lên: 12/08/2014, 16:20

... bis-Cys31,Cys32-S-carboxyamidomethylated-BS-RNase; MAE, monomeric bis-Cys31,Cys32-S-aminoethylated-BS-RNase; MSSAE, monomeric bis-Cys31,Cys32-S-ethylamine-BS-RNase; MSSG, monomeric bis-Cys31,Cys32-S-glutathione-BS-RNase; CRI, ... cannot fit into the horseshoe cavity of the inhibitor, whereas a monomeric form of the enzyme can, and is fully inhibited by CRI. Indeed, monomeric RNases lacking cyt...

Ngày tải lên: 20/02/2014, 11:20

... containing only molecules with the corresponding specific sorting signals. In the sorting by retention hypothesis, certain compounds entering the immature granules may carry sorting motifs that inter- act ... possibly in lysosomal compartments. Interestingly, several ‘lysosomal’ proteases, e.g. cathep- sin C, cathepsin D and cathepsin E, have been found not only in lysosomes but also in...

Ngày tải lên: 07/03/2014, 11:20

... domain does not bind a ligand [11], both the FixL PAS domain and PYP are activated by ligands; in FixL, oxygen binding at the heme binding PAS domain controls the activity of a h istidine kinase ... heterodimer then induces transcription of genes encoding xenobiotic metabolizing enzymes [2]. Understanding the PCDD±AhR binding process at a molecular level is therefore a key step for gainin...

Ngày tải lên: 24/03/2014, 00:21