Báo cáo y học: "PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse" ppt

... Access Research PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse Carine Delayre-Orthez 1 , Julien Becker 1 , Isabelle Guenon 2 , Vincent Lagente 2 , Johan Auwerx 3 , Nelly Frossard 1 ... chemokine expression by lipopolysaccharide in vitro and in vivo. J Immunol 1999, 163:1537-1544. 6. Goodman RB, Pugin J, Lee JS, Matthay MA: Cytokine...

Ngày tải lên: 12/08/2014, 18:22

... for review by the Editor -in- Chief of Retrovirology. Competing interests The authors declare that they have no competing interests. Authors' contributions SMS conceived of the study, designed ... resulting in neither disease nor horizontal transmission. Furthermore, the commercial assay for establishing the existence of active infection, namely PCR for HIV-2 provi- ral DNA...

Ngày tải lên: 13/08/2014, 05:21

... emphysema. However, the influence of smoking and its cessation on airway inflammation and MMP-12 expression during COPD is still unknown. We aimed to analyse airway inflammatory cell patterns in induced ... that inflammation initiated by smoking leads to a changes in both – airways and lung parenchyma. The main known contribution of smoking is activation and recruitment of...

Ngày tải lên: 12/08/2014, 15:21

... expression in bovine and human OA chondrocytes. Mithramycin dose-dependently diminished these inductions. TNF-α -induced MMP gene expression is inhibited by mithramycin TNF-α is another prominent inflammatory ... prevents the binding of Sp1 to its cognate DNA [19]. MMP-3 and MMP-13 induction by the three major inflammatory cytokines and inhibition by mithramycin imply that inter...

Ngày tải lên: 09/08/2014, 06:22

... Hirota JA, Budelsky A, Smith D, Lipsky B, Ellis R, Xiang YY, Lu WY, Inman MD: The role of interleukin-4Ralpha in the induction of glutamic acid decarboxylase in airway epithelium following acute house ... 15 The data demonstrate there is expression of genes for a complete GABAergic system in the airway epithelium. Interestingly, the expression of GAD67 was markedly modifie...

Ngày tải lên: 12/08/2014, 11:22

... may be spoiled by inaccurate positioning of the interacting groups. The contact area of the distamycin amidinium end was investigated by evaluating the hydrogen positions and interaction energy ... These confirmed that in the refined crystal geometry the drug is rather too tightly packed against the G19 base. The interaction can be improved by locally relaxing the drug...

Ngày tải lên: 24/03/2014, 04:21

... by the age-associated increases in the staining of thymocytes and microenvironmental cells, including the multilocular fat-storing cells. These data suggest that chemokines may influence the ... simply fill a space left by the thymic lymphoid compartment or replace the lymphocytic perivascular space. In the present study, we defined not only thymic unilocular adipo...

Ngày tải lên: 08/08/2014, 18:20

... impulsivity. The P4 was designed by one of the consultant child psychiatrists in the team and has been in use for 15 years as one of the tools available for screening the core symptoms of ADHD. The ... used in everyday clinical practice are needed. Challenges in clinical practice In the specialist ADHD clinic in East and North Hertfordshire, UK, assessment i...

Ngày tải lên: 09/08/2014, 01:21

... localised in the lining layer. Second, FAP expression by RA FLSs is mainly by FLSs of the myofibroblastic phenotype. Third, RA joints show an accumulation of MMP-1 and MMP-13, in concert with the v3 ... and chronic inflammation of the synovial membranes that invade deeply into the articular cartilage and bone. Activated fibrob- last-like synoviocytes (FLSs) in the lini...

Ngày tải lên: 09/08/2014, 08:23

... (Aptivus®, the latest entry to the PI class in 2005 quarter 3). (Neither of these drugs is featured individually but contributes to the category "Other PIs.") Similarly to the NRTIS, the later ... price increases of drugs once they are being marketed. The first factor driving the increase in Medicaid prescrip- tions over the past decade and a half is the move f...

Ngày tải lên: 10/08/2014, 05:20