Báo cáo y học: "Exhaled 8-isoprostane in childhood asthma" ppt

... chemistry of a tetrahedral methyl carbon in methyl lysine differs substantially from the planar carbonyl carbon of acetyl lysine (Fig. 2B). In fact, it is currently unknown whether lysine or arginine ... substantially in the two forms of lysine modification. In monomethyl lysine, the nitrogen is bonded to a tetrahedral methyl carbon and positive charge is maintained. In acetyl lysine...

Ngày tải lên: 31/03/2014, 21:21

... modifications regulating inflammatory processes The transcription factor NF-κB plays a central role in the induction of genes involved in immunity and inflammation, including cytokines, chemokines, adhesion ... regions. Methyl CpG-binding proteins use transcriptional corepressors for transcriptional silencing or may modify the surrounding chromatin of methylated regions [27]. In oncogen...

Ngày tải lên: 09/08/2014, 13:21

... cycle as observed in highly synchronized cells of tobacco BY-2. Planta 1994, 193:567-572. 33. Terasaki Y, Fukuda Y, Ishizaki M, Yamanaka N: Increased expres- sion of epimorphin in bleomycin-induced ... gelatin zymography studies for matrix metallopro- teinases in bleomycin-induced pulmonary fibrosis. Pathol Int 1998, 48:954-963. 26. Kunugi S, Fukuda Y, Ishizaki M, Yamanaka N: Role of...

Ngày tải lên: 12/08/2014, 18:21

... likely to turn rapidly to exit strategies. To the research community gathered recently for a Keystone meeting on molecular helminthology in Colorado, however, these organisms are fascinating highpoints ... protein-coding genes. TIGR and the Sanger Institute have been pursuing a whole-genome shotgun strategy, and reported a ninefold coverage assem- bly. A major issue in assembly has been p...

Ngày tải lên: 14/08/2014, 14:21

... the mainstay of treatment in childhood asthma but measurement of airway inflammation using tradi- tional invasive procedures is not feasible in children. Bronchial biopsy is invasive and non-invasive ... analysis. This has been shown not to affect 8-isoprostane concen- trations over six months of storage [10]. 8-isoprostane assay 8-isoprostane was assayed by an enzyme-linked immun...

Ngày tải lên: 12/08/2014, 18:21

... the true incidence of infection. This is due to the majority of childhood HB cases being asymptomatic. While these factors may affect the yearly incidence estimate, changes in the incidence ... newly identified, clinically recognized Int. J. Med. Sci. 2005 2 145 cases with HBV infection in children. Furthermore, the present surveillance was carried out using a predefined operat...

Ngày tải lên: 02/11/2012, 11:08

... tool for detecting and monitoring airway inflammation and disease severity. Introduction Asthma is a chronic inflammatory disease of t he air- ways. Eo sinophils play a cruci al role in the pathogenesis of ... uncovered. The results of this study have confirmed the possibility of using eotaxin-1 measurements in EBC. It is worth noting that, in this study, increased eotaxin-1 levels in...

Ngày tải lên: 12/08/2014, 11:22

... study in childhood asthma, showing that exhaled NO does help to describe aclinicallyusefulphenotypedespiteitsabilityto describe underlying pathophysiology (inflammation and modified airway smooth ... (38/46 with partially/uncontrolled asthma, 20/46 with a recent exacerbation). Interestingly, these two clusters only dif- fer by their underlying severity factors, namely increased airway ton...

Ngày tải lên: 12/08/2014, 13:22

... severity in ex-smokers with COPD in our study, in contrast to cur- rent smokers, is supported by previous findings suggest- ing that the inflammatory effects of current smoking may mask the underlying ... is evidence that airway inflammation is present in COPD patients even after smoking cessation [15]. Inter- estingly, in a longitudinal study involving bronchial biopsies in patie...

Ngày tải lên: 12/08/2014, 13:22

... inflammation in the airways and bronchial hyperre- activity after exercise. The airway epithelium is involved in allergic inflamma- tory processes, producing and releasing endothelins, cytokines, ... the increase in ET-1 level in EBC occurs. Based on these findings, it is considered that the release of endothelin-1 through interactions with other cytokines and the influence on many ai...

Ngày tải lên: 12/08/2014, 15:21