Báo cáo y học: " Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways" pot

... synthesis [4,5]. In the present study we therefore tested the hypothesis that acti- vation of the SPHK/S1P signalling pathway may contrib- ute to MR-dependent regulation of peripheral airway diameter. ... of 14 (page number not for citation purposes) Respiratory Research Open Access Research Activation of the SPHK/S1P signalling pathway is coupled to...

Ngày tải lên: 12/08/2014, 18:21

... employing perdeuterated methyl iodide excluded the presence of methylated mono- saccharide constituents. Analysis of total KLH glycans In order to take an overview of the complexity of KLH glycosylation, ... structures may be proposed. DISCUSSION The main purpose of this study was to give a first, detailed account of carbohydrate structures of KLH. To this end, whole...

Ngày tải lên: 31/03/2014, 08:20

... significantly during the first year in both study groups, but the rise was not sustained until the end of the trial. One hypothesis to explain this finding is that vitamin D 3 , which affects the immune ... BMD and replacement therapy has been shown to increase bone mass [3]. GH is the primary inducer of IGF-1 synthesis by the liver and a central regulator of the...

Ngày tải lên: 09/08/2014, 01:21

... with the metabolism and/or potentiate the nephrotoxicity of indomethacin [10]. In our patient, the administration of Table 1: Evolution of analytical data Admission to the PICU Start of CRRT End of ... program, with a system of dose error alarms. It is routinely the resi- dent who writes the prescription and this is supervised by the staff physician and confirm...

Ngày tải lên: 11/08/2014, 19:21

... model. The second objective of the analyses was to test the hypothesis that, among those with CAC, Agatston scores will be directly proportional to sUA concentra- tion. The distribution of these ... 10). The choice of these cutoffs was dictated by the statistical dis- tribution of Agatston score in our young population. The first objective w as to examine the rel...

Ngày tải lên: 12/08/2014, 15:23

... assays to detect the immunodeficiency? Finally, are there any therapeutic options to reverse the immune deactivation? Mechanisms of immune deactivation Activation of the stress response plays ... deactivates their inflammatory and antigen-presenting pathways. In summary, the greater the inflammation and injury, the greater the counter -regulation. Measurement of imm...

Ngày tải lên: 12/08/2014, 18:21

... apoptosis in cells in the S phase of the cell cycle (reviewed in [45]). Etoposide is a topoisomerase II inhibitor, which induces apoptosis via the intrinsic pathway[ 46,47]. TRAIL is a member of the ... more susceptible to camptothecin-induced apoptosis. Camp- tothecin is a topoisomerase I inhibitor, which induces apoptosis in cells in the S phase of the cell cycle...

Ngày tải lên: 13/08/2014, 05:22

... reported by males might be partly explained by the high frequency of body searching to which Kashmiri men are subjected. Whether the body searching is perceived as inappropriate touching (part of the ... Disorder) and major depressive disorder [4]. Very little is known about the psychological impact of the insecurity on the Kashmiri population. To assist in determini...

Ngày tải lên: 13/08/2014, 13:21

... in the S2 cell model system with which Bard et al. [12] have looked into another fundamental cellular process - protein secretion. The secretory pathway The secretory pathway is the compulsory ... Thus, the selection by Bard et al. [12] may have eliminated some regulators of the exocytic pathway that hinder cell growth rate directly or indirectly. To exclude the poss...

Ngày tải lên: 14/08/2014, 16:21

... of mutant PS1 increased the susceptibility of PC12 cells to apoptosis induced by Ab or the withdrawal of trophic factors. In contrast with this proapoptotic effect of PS1 mutants, the wild type ... PS1 suppresses apoptosis induced by the activation of p53 [36], which is a target of JNK. Therefore, increasing evidence is indicating the importance of the JNK/c-...

Ngày tải lên: 08/03/2014, 09:20