Báo cáo y học: "Expression of the α7 nicotinic acetylcholine receptor in human lung cells" pdf
... acetylcholine receptor, it was necessary to show if expression of the α7 nicotinic acetylcholine receptor protein in seen in these cell lines. Using a specific anti- body for the α7 nicotinic acetylcholine ... nitrosamine, 4(methylnitrosamino)-1-(3-pyridyl)- 1-butanone (NNK), is a high affinity agonist for the α7 nicotinic acetylcholine receptor (α7 nAChR...
Ngày tải lên: 12/08/2014, 18:21
... receptors on the binding of acetylcholine The binding properties of ACh were investigated in intact Xenopus oocytes expressing WT and mutant nAChR. The affinity of the mutant receptors for ACh was ... effect. In contrast, the replacement of cE93 by an arginine conferred an eight-fold increase in the potency for acetyl- choline-induced receptor activation. In th...
Ngày tải lên: 19/02/2014, 07:20
... accumu- lation of ade fluorescent dye after galactose induction. When the genes were overexpressed by induction, accumulation of the dye in the vacuoles of both transformants was observed, and the intensity ... V-ATPase complex in the vacuolar-membrane- enriched fraction of the respective transformant. The antibody against the subunit A in yeast V 1 portion and th...
Ngày tải lên: 08/03/2014, 23:20
Báo cáo Y học: Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues docx
... by a liver-specific deficiency in argininosuccinate synthetase (ASS). In the liver, the AGC plays an important role in the urea cycle by providing aspartate for incorporation into argininosuccinate ... T. (1980) Role of argininosuccinate synthetase in the regulation of urea synthesis in the rat and argininosuccinate synthetase-asso- ciated metabolic disorders in man. A...
Ngày tải lên: 24/03/2014, 04:21
Báo cáo Y học: Expression of the uncoupling protein 1 from the aP2 gene promoter stimulates mitochondrial biogenesis in unilocular adipocytes in vivo potx
... 3¢,3¢-diaminobenzidine hydrochloride c hromogen (Sigma). The speci®city of the method was tested by the omission of the primary antibody in the staining, and the use of p reimmune serum instead of the ... ecreasing in situ lipogenesis. In order to further analyse consequences of respiratory uncoupling in white fat, the eects of the ectopic UCP1 on the...
Ngày tải lên: 31/03/2014, 15:20
Báo cáo y học: "Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells" pps
... in the highly vascular endothelium expressed CCL5 protein (Figure 6). In addition, staining was demonstrated at the synovial lining and on many infiltrating inflammatory cells. Protein levels of ... chemokine CCL5 [39,40]. The memory population may be further divided by the expression or loss of expression of CCR7 [12]. We and others have previously shown that the majority...
Ngày tải lên: 09/08/2014, 07:20
Báo cáo khoa học: Expression of the Pycnoporus cinnabarinus laccase gene in Aspergillus niger and characterization of the recombinant enzyme pdf
... obtained as compared with 45 mgÆL )1 of wild-type laccase from the dikaryotic strain I-937 of P. cinnabarinus and 145 mgÆL )1 from the derived monokaryotic strain ss3 of P. cinnabarinus. In order ... an 8 0-fold increase in laccase produc- tion. The identity of the recombinant protein was further confirmed by immunodetection using Western b lot analysis and N -terminal sequ...
Ngày tải lên: 17/03/2014, 11:20
Báo cáo y học: "Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy" pps
... activity in spondyloar-thropathy (SpA) (lining-layer hyperplasia, inflammatory infiltration, polymorphonuclear cells, sublining CD68, and sublining CD163)Supervised clustering analysis using the synovial ... observed in both the synovial lining layer and the synovial sublining layer, these markers were scored separately in the two compartments. An overview of the 15 synovial...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: ":Evaluation of the Patient Acceptable Symptom State in a pooled analysis of two multicentre, randomised, double-blind, placebo-controlled studies evaluating lumiracoxib and celecoxib in patients with osteoarthritis" pptx
... those in the placebo group at week 2 (Tables 2, 3, 4, 5). Achievement of sustained PASS during the study Achievement of a sustained satisfactory symptom state according to PASS, maintained from the ... presentation of results at an individual level rather than a group level (as expressed by the mean change in symptom score) [2]. The challenge of the meeting was to dete...
Ngày tải lên: 09/08/2014, 10:20
Báo cáo y học: "Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids" docx
... can catalyze the metabolism of AA to the proinflammatory eoxins that can increase permeability of the endothelial cell monol- ayer in vitro, indicating that they can enhance vascular perme- ability ... detectable 5-LO staining may therefore be explained in part by the specific B-cell subsets present in RA synovium. The wide expression of 5-LO in the synovial tissue...
Ngày tải lên: 09/08/2014, 14:21