Báo cáo y học: " Predominant constitutive CFTR conductance in small airways" pot

... increase intra- cellular Ca 2+ effectively. Third, CFTR is known to be inhib- ited by NPPB, CFTR Inh -172, and GlyH-101[19,21]. These inhibitors had varying, but consistently inhibitory effects on ... in airway surface liquid composition. Journal of Applied Physiology 1981, 50:613-620. 31. Reddy MM, Quinton PM: Hydrolytic and nonhydrolytic interac- tions in the ATP regulation of CFT...

Ngày tải lên: 12/08/2014, 18:21

... determined by genome-wide expression profiling [14]. Beyond direct cartilage destruction, RASFs maintain inflam- mation in synovial joints and induce chondrocyte dysfunction by releasing proinflammatory ... path- ways involved in cytokine/chemokine activity (cytokine- cytokine receptor interaction and Jak-STAT signalling), matrix remodelling (focal adhesion, TGF-β signalling, and ECM rece...

Ngày tải lên: 09/08/2014, 01:22

... metabolomics by mass spectrometry, in conjunction with high-throughput parallel sequencing to delineate transcriptome structure, is enabling an inte- grated approach to investigating the physiology of ... in gathering together a research community involved in the genome-based exploration of eukaryotic diversity. It made an ideal setting to let specialists from distinct fields, stud...

Ngày tải lên: 09/08/2014, 20:21

... The DNA binding bHLH domain [59,62] and the protein-protein interacting PAS domain are highly conserved in organisms ranging from cyanobacteria to mammals [63]. The KaiA protein in cyanobacteria ... is quite unlikely that rhythmic photosynthesis in the wild type strain could be maladaptive under LL, as continuous pho- tosynthesis in arrhythmic strains may adversely affect oxy- gen lab...

Ngày tải lên: 10/08/2014, 09:20

... trimodality treatment in SCLC. The study included 95 patients, the majority being in stages I and II. Patients were divided in two groups. Group I received surgery followed by adjuvant, mainly platin ... Pastorino [18] concluded that surgery can be pro- posed in T1, T2/N0 disease followed by adjuvant chemo- therapy. Surgery in stages II and III must be planned in a multidisciplina...

Ngày tải lên: 10/08/2014, 10:20

... lung injury by inducing expression of cytokines including tumor necrosis factor and IL-6 and IL-8 [149]. These cytokines may in turn stimulate the production of many inflammatory mediators, leading ... in the initial events in lung injury by activating neutrophils to aggregate and release elastase and oxygen radicals, increasing neu- trophil adherence, activating mast cells, and inducin...

Ngày tải lên: 12/08/2014, 18:20

... studies in cystic fibrosis have found tantalizing results in genes involved in infection and inflammation, but many other relevant pathways remain untapped. Genome scanning approaches may eventually ... allele of the murine cystic fibrosis transmembrane conductance regulator (CFTR) could be modified by different strain backgrounds. They genetically mapped a locus conferring the modif...

Ngày tải lên: 12/08/2014, 18:20

... Lepley RA, Goulet JL, Koller BH, Fitzpatrick F: Inhibition of 5-lipoxygenase-activating protein (FLAP) reduces pulmonary vascular reactivity and pul- monary hypertension in hypoxic rats. J Clin Invest ... activating protein was shown in endothelial cells of plexiform lesions and inflammatory cells in patients with PPH, suggesting that overexpression of enzymes involved in generation o...

Ngày tải lên: 12/08/2014, 18:20

... while maintaining infection control measures), and serve as a way to train treatment teams at different hospital sites. Indeed, internet-based technology proved invaluable during the SARS outbreak in ... placed in quarantine after exposure, some of them falling ill, becoming critically ill and even succumbing to SARS. Staff morale was addressed in some institutions by encouraging and co...

Ngày tải lên: 12/08/2014, 20:21

... purpose we have built a homology model of human PXR in order to identify residues that were likely to be involved in ligand binding. Since the initiation of this study the crystal structure of the human ... determinant for the transcrip- tional regulation of the drug metabolizing enzyme family of heme-containing monooxygenases P450 CYP3A [1–4]. Consequently this nuclear receptor is likely...

Ngày tải lên: 08/03/2014, 16:20