Báo cáo y học: " Predominant constitutive CFTR conductance in small airways" pot
Báo cáo y học: " Predominant constitutive CFTR conductance in small airways" pot
... increase intra-
cellular Ca
2+
effectively. Third, CFTR is known to be inhib-
ited by NPPB, CFTR
Inh
-172, and GlyH-101[19,21]. These
inhibitors had varying, but consistently inhibitory effects
on ... in airway surface liquid composition. Journal of Applied
Physiology 1981, 50:613-620.
31. Reddy MM, Quinton PM: Hydrolytic and nonhydrolytic interac-
tions in the ATP regulation of CFT...
Báo cáo y học: "Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration" potx
... determined by
genome-wide expression profiling [14].
Beyond direct cartilage destruction, RASFs maintain inflam-
mation in synovial joints and induce chondrocyte dysfunction
by releasing proinflammatory ... path-
ways involved in cytokine/chemokine activity (cytokine-
cytokine receptor interaction and Jak-STAT signalling), matrix
remodelling (focal adhesion, TGF-β signalling, and ECM
rece...
Báo cáo y học: " Unraveling the genomic diversity of small eukaryotes" potx
... metabolomics by mass spectrometry, in
conjunction with high-throughput parallel sequencing to
delineate transcriptome structure, is enabling an inte-
grated approach to investigating the physiology of ... in gathering together a research
community involved in the genome-based exploration of
eukaryotic diversity. It made an ideal setting to let
specialists from distinct fields, stud...
Báo cáo y học: "Evolution of temporal order in living organisms" pot
... The DNA binding bHLH
domain [59,62] and the protein-protein interacting PAS
domain are highly conserved in organisms ranging from
cyanobacteria to mammals [63]. The KaiA protein in
cyanobacteria ... is quite
unlikely that rhythmic photosynthesis in the wild type
strain could be maladaptive under LL, as continuous pho-
tosynthesis in arrhythmic strains may adversely affect oxy-
gen lab...
Báo cáo y học: "Current role of surgery in small cell lung carcinoma" pot
... trimodality treatment in
SCLC. The study included 95 patients, the majority being
in stages I and II. Patients were divided in two groups.
Group I received surgery followed by adjuvant, mainly
platin ... Pastorino [18] concluded that surgery can be pro-
posed in T1, T2/N0 disease followed by adjuvant chemo-
therapy. Surgery in stages II and III must be planned in a
multidisciplina...
Báo cáo y học: " Role of endothelin-1 in lung disease" potx
... lung
injury by inducing expression of cytokines including tumor
necrosis factor and IL-6 and IL-8 [149]. These cytokines
may in turn stimulate the production of many inflammatory
mediators, leading ... in the initial events in
lung injury by activating neutrophils to aggregate and
release elastase and oxygen radicals, increasing neu-
trophil adherence, activating mast cells, and inducin...
Báo cáo y học: " Modifier genes and variation in cystic fibrosis" pot
... studies in cystic fibrosis have found tantalizing
results in genes involved in infection and inflammation, but many other relevant pathways remain
untapped. Genome scanning approaches may eventually ... allele of the murine cystic
fibrosis transmembrane conductance regulator (CFTR)
could be modified by different strain backgrounds. They
genetically mapped a locus conferring the modif...
Báo cáo y học: "Genomic approaches to research in pulmonary hypertension" pot
... Lepley RA, Goulet JL,
Koller BH, Fitzpatrick F: Inhibition of 5-lipoxygenase-activating
protein (FLAP) reduces pulmonary vascular reactivity and pul-
monary hypertension in hypoxic rats. J Clin Invest ... activating
protein was shown in endothelial cells of plexiform lesions
and inflammatory cells in patients with PPH, suggesting
that overexpression of enzymes involved in generation o...
Báo cáo y học: "Clinical review: SARS – lessons in disaster management" potx
... while
maintaining infection control measures), and serve as a way to
train treatment teams at different hospital sites. Indeed,
internet-based technology proved invaluable during the SARS
outbreak in ... placed
in quarantine after exposure, some of them falling ill,
becoming critically ill and even succumbing to SARS.
Staff morale was addressed in some institutions by
encouraging and co...
Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... purpose we have built a
homology model of human PXR in order to identify
residues that were likely to be involved in ligand binding.
Since the initiation of this study the crystal structure of the
human ... determinant for the transcrip-
tional regulation of the drug metabolizing enzyme family of
heme-containing monooxygenases P450 CYP3A [1–4].
Consequently this nuclear receptor is likely...
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