Báo cáo y học: "Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa" pps

... purposes) Respiratory Research Open Access Research Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa André Dagenais* †1 , Diane Gosselin †2 , Claudine ... be significant. Results Inflammation in mice infected with P. aeruginosa The inflammation process evoked by Pseudomonas instilla- tion in the l...

Ngày tải lên: 12/08/2014, 18:21

... infection of epithelial cells induce the expression of several proinflammatory cytokines and chemokines both in vitro and in vivo , which could be linked to the consequence of fatal hypercytokinemia ... detecting receptors, which may result in excessive secondary cytokine/chemokine response. Secondly, the viruses may directly or indirectl y interfere w ith the bal- ance of...

Ngày tải lên: 12/08/2014, 02:20

... KIR3DS1 and the inhibitory 3DL1 are located in the intracytoplasmic tail. The inhibitory receptor has a long tail containing immunoreceptor tyrosine inhibitory motifs, whereas the activating receptor ... forms of HLA-B27 by KIR or ILT could influence their immunomodulatory function and may imply a role in inflammatory disease. Binding of the KIR3DL1 receptor to the Bw4 family of MHC...

Ngày tải lên: 09/08/2014, 08:22

... PR Thr-Val-Ser-Tyr-Glu-Leu-OH 12 Kinetic analysis [20] Palmitoyl-Thr-Val-Ser-Tyr-Glu-Leu-OH 0.5 Kinetic analysis [20] Palmitoyl-Tyr-Glu-Leu-OH 0.15 Kinetic analysis [21] Palmitoyl-Tyr-Glu-( L -threonine)-OH ... 0.05 Kinetic analysis [21] Palmitoyl-Tyr-Glu-(p-biphenyl-alanine)-OH 0.025 Kinetic analysis [21] Cross-linked Interfacial Peptides >50 Protein cross-linking [18] 2.0 Gel-filtration;...

Ngày tải lên: 08/03/2014, 09:20

... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distorted binding of the loops results in cleavage of the Gly(9)-Ala10 bond. FEBS Lett. 361, ... a serine peptidase characterized by oligopeptidase activity. It is grouped in family S9A in clan SC [1]. Enzymes belonging to clan SC are distinct from trypsin-type and subtilisin-type...

Ngày tải lên: 31/03/2014, 08:20

... joints investigated by intravital microscopy within the first 24 hours, inflammatory cell responses in the synovial tissue were clearly provoked. Activation by inflammatory stimuli after antibody transfer ... CD18 integrins in leukocyte rolling and adhesion, it was consistent to propose blocking effects of ALP on leukocyte rolling in vivo as an additional interference with selectin...

Ngày tải lên: 09/08/2014, 08:22

... regulated by distinct kinase pathways independent of inhibitor of κB kinase (IKK). Here, we examine the role of protein kinase C isoforms and janus activated kinase 2 (JAK2) activation in NF-κB ... Amersham, UK) by electroblotting. Equal protein loading was confirmed by Ponceau S stain- ing of the membrane. Non-specific protein binding was blocked by incubation of the membrane in...

Ngày tải lên: 11/08/2014, 08:21

... vaccination results in a greater number of individuals capable of responding to skin test- ing, but the durability of this response varies between individuals and the diameter of induration diminishes with ... immunity against initial infection and systemic progression. The kinetics of lymphoproliferative response described in this study are similar to those previously describ...

Ngày tải lên: 11/08/2014, 10:23

... challenged with ovalbumin and then treated intranasally with chitosan nanoparticles containing pVD. Parameters of airway inflammation, such as airway hyperreactivity, proinflammatory cytokine levels, ... TH2 inflammatory cytokines IL-4, IL-5 and IL-13 Generation of pathogenic Th2 cells is the main cause of asthma. We measured a panel of proinflammatory cytokines in lung homog...

Ngày tải lên: 12/08/2014, 14:20

... activa- tion of lysine hydroxylase and hydroxylysine glycosyltransferase, allowing partial glycosylation of the product. This system closely mimics the post-transla- tional system of mammalian ... sustained release of the material directly into the joint cavity, greatly decreasing the amount of material required and the number of injections necessary. Second, the absence of inte...

Ngày tải lên: 12/08/2014, 14:22