Báo cáo y học: "Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts" docx

... by TGFβ included known target tropomyosin (TPM1). Interest- ingly, smoothelin, a smooth muscle gene recently reported to be highly induced by TGFβ in fetal lung fibroblasts [18], was also induced by ... GTP-binding pro- tein), involved in cytoskeleton remodelling, were also upregulated by TGFβ. TGFβ also induced Dickkopf1 (DKK1), a potent inhibitor of Wnt/beta-catenin signalling....

Ngày tải lên: 12/08/2014, 18:21

... Heslington, York YO10 5NY, UK. † YCR Cancer Research Unit, Department of Biology, University of York, York YO10 5YW, UK. ‡ Hull York Medical School, University of York, Heslington, York YO10 ... genes by flow cytometry and immunocytochemistryFigure 4 Validation of selected genes by flow cytometry and immunocytochemistry. (a) Flow cytometry analysis of prostate cancer cells co-stained with...

Ngày tải lên: 14/08/2014, 08:21

... by genes encoding interleukins, chemokine receptors and ligands, and by those involved in antigen recognition and processing. Keywords: DNA expression array, differential gene expression, inflammation, ... of molecular interactions in an inflamed joint, deduced from gene expression studies in both RA and its corresponding animal models, involves pro- teins participating in immuni...

Ngày tải lên: 09/08/2014, 06:22

... significantly overexpressed at baseline in poor responders are induced by several cytokines in FLSs, thereby suggesting a role for these cytokines in the resistance to TNF blockade in RA. ANOVA: analysis ... thereby preventing disease progression in these patients and saving unnecessary costs. TNF antagonists interfere with many pathways involved in RA synovial inflammatory proces...

Ngày tải lên: 09/08/2014, 14:20

... enumeration. In cytogram (c), R4 is defined as FSC (Forward Scatter)/SSC gate on lymphocytes set on FSC left-hand border and include intermediate region between lymphocytes and monocytes. In cytogram ... used in combination, since both these markers are individually expressed by other cell types, such as activated T-lym- phocytes, pericytes, bone marrow fibroblasts, nerve fibers and leu...

Ngày tải lên: 12/08/2014, 14:22

... was recently found to be involved in the control of hepcidin expression [23], in the B6 strain. Finally, and worthy of note within the context of modifiers of iron loading severity, wild- type D2 ... microarrays customized to analyze a selection of 300 genes encoding pro- teins that are directly involved in iron metabolism or in linked pathways [11]. Of note, expression of genes t...

Ngày tải lên: 14/08/2014, 08:20

... photosynthesis on our planet. Morpholog ica lly, they exhibit different shapes and symmetries, the centric diatoms being radially symmetric and the pennates dis- playing bilateral symmetry. In spite ... fused into a consensus sequence using PHRAP [55]. Sequence analysis The complete set of cDNAs was subject to a preliminary analysis as previously described in [22], with a variation in o...

Ngày tải lên: 09/08/2014, 20:22

... the inflammatory process and IL-13 expression in macrophages was suppressed by theophylline in a dose-dependent mannerFigure 3 IL-13 expression in macrophages was suppressed by theophylline in ... Hitsuda Y, Matsumoto Y, Sasaki T: Functional assay of NF-kappaB translocation into nuclei by laser scanning cytometry: inhibitory effect by dex- amethasone or theophylline. Naunyn Schm...

Ngày tải lên: 12/08/2014, 18:22

... coronary artery outcome using significance analysis of microarrays (SAM) [13]. We did not identify any genes whose expression differed significantly using the criterion of coronary artery outcome. ... these clinical features, and may also pro- vide insight into physiological properties of the immune system. For example, the increased abundance of immu- noglobulin λ chain transcripts in yo...

Ngày tải lên: 14/08/2014, 08:20

... malig- nant lung tumors. The histopathological diagnosis was based on routinely processed hematoxylin-eosin stains and confirmed by immunohistochemical staining look- ing for pan-cytokeratin, cytokeratin ... agents, which selectively target cell cycle pro- teins. For example, flavopiridol has the ability to induce cell cycle arrest by binding and inhibiting different cyclin- dependent kinas...

Ngày tải lên: 18/06/2014, 15:20